| Definition | Escherichia fergusonii ATCC 35469 chromosome, complete genome. |
|---|---|
| Accession | NC_011740 |
| Length | 4,588,711 |
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The map label for this gene is clpP1 [H]
Identifier: 218550008
GI number: 218550008
Start: 2767926
End: 2770199
Strand: Reverse
Name: clpP1 [H]
Synonym: EFER_2693
Alternate gene names: 218550008
Gene position: 2770199-2767926 (Counterclockwise)
Preceding gene: 218550009
Following gene: 218550007
Centisome position: 60.37
GC content: 56.55
Gene sequence:
>2274_bases TTGATCCCGTCAAAGAGGCTGCAGCATGGCGGGCCATTCTTCGTGGTGGAGCAGGAACAGAAGCCGAGTGGATCCGTGCC AGAGGGCAGTCACCGCAGGAGGTCAAACGCCAGCGAATGCGTGAAACCGAATTTAACCGACAAAACGGGCTGGTGTTCGA TTCTGACGCCGCCAACGATAAAGGAGTGCTCCCTGATGCAGCAAATGATAAGCCCGCCCTGTCGCGGGATGACGATTAAT CCCCGCGCCAGCCTTGCGGGTGTCGATGCCGCAAACGGTCAGTGCTGGTACGAAATCCGTGCACAGGCAACCGGACGGGT GGAAATTTTCCTCTATGACGTGATTGGTGGATGGGGCATCACCGCGCAGCAGTTTATCACTGACTGTAAAGATGCGGGGG TGTTTGAGGCCAGCGCCATTGATCTGCATATCCACAGCCCGGGCGGTGATGTGATGCAGGGCTTTGCCATCTTTAACACG CTGTCACGCCTGAAAGCGAAGGTGGATATCTGGGTGGATGGTGTCGCTGCCAGTATGGCATCGATGATCGTCTGCCTTCC CGGAGCCACAGTACATATGCCTGAAAACGCCTGGATTATGGTGCATAAGCCCTGGGGCGGGATCGCCGGTGATTCCGATG ATATGCGTGATTATGCCGACTGGCTGGATCGCAACGAGGCGCTGATGCTGTCTGCCTACATGAATAAAACCGGACTGGGG CAGGAGGAGCTGGAGGCCATGCTGAAATCGGAAACCTGGCTCAGCGGCGCTGAAGCTGTGGAAAAGGGCTTTGCAGACTC CCTCGAACCCGAATTACAGGCTGCGGCCTGTGTGAACCAAAATAAACTGAAGGATTATCAGAATATGCCAGAACAGGTTA ATGCTCTTTTTGCTCCGCGTGCAGAAACTCAGGTTACCCCACTGCAGGCCAGCCAGCCTCCGGCACCACAGGTATCTCAG GACACACCGCAGCCAGGCGCCGTAGATATTGCCGCGCTGGCCACTCAGCTACAGCAGCAGATGCAGGCTGCCAATGCGGA ACGCGTGAACGCCGTCTCTGCCGTGTTCGACGCATTTCCGGCATTCGCCTCGCTGAAAGCGGAATGCCTGAGCGATTTCA CCTGCTCGGCTGAAAAAGCCCGTGAACGACTGCTGCAGGCGCTGGCGGCGGGTACCACGCCCTGTGCCGGGCCGGGAGCA GCACACATTTACGCAGGAAACGGCAATCTGGTGGGTGATTCCATCCGTGCAGCAGTGATGGCTCGCGCAGGGTACAGCGA AGCCGAAAAAGACAATGCCTATAACGGCTTTACGCTACGCGAACTGGCGCGTGCCTCACTGGTGGATCGCGGCATCGGAA TTTCCGGACATGCCGCACCGATGGCAATGGTGGGGCTGGCATTCACCCACAGTGGCAGTGACTTTGGCAATATCCTGATG GATGTTGCTCACAAAGCGGCACTGCAGGGCTGGGGCAGCGCCAGTGAAACGTTTGACCAGTGGACCCGCAAGGGCACGCT GTCAGATTTTAAAACTGCCCACCGTGTGGGGCTGGAGGCTTTCCCGACCCTGCGACAGGTTCAGCCGGGCGCTGAATATA AGTATGTAACCCTTAAAGATCGCGGTGAGCCCATTGCGCTGGCTACGTATGGCGAACTCTTCAGCATTGATCGCCAGACC ATCATTAACGATGACCTGGATATGCTGACCCGTATTCCGATGGCAATGGGAGCAGCAGCGCGTACCACAGTGGGCGATCT TGTCTGGGCCGTACTGACCAGCAACCCGAAAATGTCTGATGGTAAACCGTTGTTCCATGCCGATCACGGCAACCTGGTGA CTGCGGATCTGTCCATTGAAGGACTGGATGCAGGGCGTAAAGCCATGTTGCTGCAAAAGTCCGGTAGCCGCCGCCTGAAT ATTCGTCCGGCCTTTATGCTGACACCTGTTGCCATTGAATCCCGGGCAAGTCAGTTAATTAAATCTTCCAGTGTACCGGG GGCAGATGCCAACAGCGGCATTGTTAACCCGATCCAGAACTTTGCCACCGTTCTGTCAGAAGCCCGTCTGGATGACAGCA GCCCGACCGATTATTACCTGGTGGCGGCACAGGGGCGTGACACGATTGAAGTGGCTTATCTTGACGGTATCGATACTCCG TATCTGGAACAGCAGCAGGGCTTTACCGTTGACGGGGCCGCATTCAAAGTGCGCATTGATGCCGGGGTCGCACCGCTTGA CTGGCGTGGCATGGTTAAAGTCAAAAAACAGTAA
Upstream 100 bases:
>100_bases GCCTGGCTGGCAATGGCGCTGCTTGATATGGATATCCCGCCTGATATCGACAAAACCACGCTCTTTAACGCGACCTATCT TGGTCCGGTGATGCCGTGGA
Downstream 100 bases:
>100_bases TTCACCGCCGCGTCAGGCGGTTTTTTTTACTCAGGCGGCACCGTCGGGAGCCGCTTATACCGGAGGTAAAAATGTCAAAA AATTATGTTCAGGACGGTAC
Product: ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp) of prophage
Products: NA
Alternate protein names: Endopeptidase Clp 1 [H]
Number of amino acids: Translated: 757; Mature: 757
Protein sequence:
>757_residues MIPSKRLQHGGPFFVVEQEQKPSGSVPEGSHRRRSNASECVKPNLTDKTGWCSILTPPTIKECSLMQQMISPPCRGMTIN PRASLAGVDAANGQCWYEIRAQATGRVEIFLYDVIGGWGITAQQFITDCKDAGVFEASAIDLHIHSPGGDVMQGFAIFNT LSRLKAKVDIWVDGVAASMASMIVCLPGATVHMPENAWIMVHKPWGGIAGDSDDMRDYADWLDRNEALMLSAYMNKTGLG QEELEAMLKSETWLSGAEAVEKGFADSLEPELQAAACVNQNKLKDYQNMPEQVNALFAPRAETQVTPLQASQPPAPQVSQ DTPQPGAVDIAALATQLQQQMQAANAERVNAVSAVFDAFPAFASLKAECLSDFTCSAEKARERLLQALAAGTTPCAGPGA AHIYAGNGNLVGDSIRAAVMARAGYSEAEKDNAYNGFTLRELARASLVDRGIGISGHAAPMAMVGLAFTHSGSDFGNILM DVAHKAALQGWGSASETFDQWTRKGTLSDFKTAHRVGLEAFPTLRQVQPGAEYKYVTLKDRGEPIALATYGELFSIDRQT IINDDLDMLTRIPMAMGAAARTTVGDLVWAVLTSNPKMSDGKPLFHADHGNLVTADLSIEGLDAGRKAMLLQKSGSRRLN IRPAFMLTPVAIESRASQLIKSSSVPGADANSGIVNPIQNFATVLSEARLDDSSPTDYYLVAAQGRDTIEVAYLDGIDTP YLEQQQGFTVDGAAFKVRIDAGVAPLDWRGMVKVKKQ
Sequences:
>Translated_757_residues MIPSKRLQHGGPFFVVEQEQKPSGSVPEGSHRRRSNASECVKPNLTDKTGWCSILTPPTIKECSLMQQMISPPCRGMTIN PRASLAGVDAANGQCWYEIRAQATGRVEIFLYDVIGGWGITAQQFITDCKDAGVFEASAIDLHIHSPGGDVMQGFAIFNT LSRLKAKVDIWVDGVAASMASMIVCLPGATVHMPENAWIMVHKPWGGIAGDSDDMRDYADWLDRNEALMLSAYMNKTGLG QEELEAMLKSETWLSGAEAVEKGFADSLEPELQAAACVNQNKLKDYQNMPEQVNALFAPRAETQVTPLQASQPPAPQVSQ DTPQPGAVDIAALATQLQQQMQAANAERVNAVSAVFDAFPAFASLKAECLSDFTCSAEKARERLLQALAAGTTPCAGPGA AHIYAGNGNLVGDSIRAAVMARAGYSEAEKDNAYNGFTLRELARASLVDRGIGISGHAAPMAMVGLAFTHSGSDFGNILM DVAHKAALQGWGSASETFDQWTRKGTLSDFKTAHRVGLEAFPTLRQVQPGAEYKYVTLKDRGEPIALATYGELFSIDRQT IINDDLDMLTRIPMAMGAAARTTVGDLVWAVLTSNPKMSDGKPLFHADHGNLVTADLSIEGLDAGRKAMLLQKSGSRRLN IRPAFMLTPVAIESRASQLIKSSSVPGADANSGIVNPIQNFATVLSEARLDDSSPTDYYLVAAQGRDTIEVAYLDGIDTP YLEQQQGFTVDGAAFKVRIDAGVAPLDWRGMVKVKKQ >Mature_757_residues MIPSKRLQHGGPFFVVEQEQKPSGSVPEGSHRRRSNASECVKPNLTDKTGWCSILTPPTIKECSLMQQMISPPCRGMTIN PRASLAGVDAANGQCWYEIRAQATGRVEIFLYDVIGGWGITAQQFITDCKDAGVFEASAIDLHIHSPGGDVMQGFAIFNT LSRLKAKVDIWVDGVAASMASMIVCLPGATVHMPENAWIMVHKPWGGIAGDSDDMRDYADWLDRNEALMLSAYMNKTGLG QEELEAMLKSETWLSGAEAVEKGFADSLEPELQAAACVNQNKLKDYQNMPEQVNALFAPRAETQVTPLQASQPPAPQVSQ DTPQPGAVDIAALATQLQQQMQAANAERVNAVSAVFDAFPAFASLKAECLSDFTCSAEKARERLLQALAAGTTPCAGPGA AHIYAGNGNLVGDSIRAAVMARAGYSEAEKDNAYNGFTLRELARASLVDRGIGISGHAAPMAMVGLAFTHSGSDFGNILM DVAHKAALQGWGSASETFDQWTRKGTLSDFKTAHRVGLEAFPTLRQVQPGAEYKYVTLKDRGEPIALATYGELFSIDRQT IINDDLDMLTRIPMAMGAAARTTVGDLVWAVLTSNPKMSDGKPLFHADHGNLVTADLSIEGLDAGRKAMLLQKSGSRRLN IRPAFMLTPVAIESRASQLIKSSSVPGADANSGIVNPIQNFATVLSEARLDDSSPTDYYLVAAQGRDTIEVAYLDGIDTP YLEQQQGFTVDGAAFKVRIDAGVAPLDWRGMVKVKKQ
Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase S14 family [H]
Homologues:
Organism=Homo sapiens, GI5174419, Length=131, Percent_Identity=30.5343511450382, Blast_Score=71, Evalue=4e-12, Organism=Escherichia coli, GI1786641, Length=138, Percent_Identity=31.1594202898551, Blast_Score=69, Evalue=8e-13, Organism=Caenorhabditis elegans, GI17538017, Length=132, Percent_Identity=35.6060606060606, Blast_Score=88, Evalue=1e-17, Organism=Drosophila melanogaster, GI20129427, Length=131, Percent_Identity=30.5343511450382, Blast_Score=72, Evalue=2e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001907 - InterPro: IPR018215 [H]
Pfam domain/function: PF00574 CLP_protease [H]
EC number: =3.4.21.92 [H]
Molecular weight: Translated: 81375; Mature: 81375
Theoretical pI: Translated: 5.15; Mature: 5.15
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 4.9 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 3.4 %Met (Mature Protein) 4.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIPSKRLQHGGPFFVVEQEQKPSGSVPEGSHRRRSNASECVKPNLTDKTGWCSILTPPTI CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCEEEECCCCCH KECSLMQQMISPPCRGMTINPRASLAGVDAANGQCWYEIRAQATGRVEIFLYDVIGGWGI HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCC TAQQFITDCKDAGVFEASAIDLHIHSPGGDVMQGFAIFNTLSRLKAKVDIWVDGVAASMA CHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHH SMIVCLPGATVHMPENAWIMVHKPWGGIAGDSDDMRDYADWLDRNEALMLSAYMNKTGLG HHEEECCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHCCCCCC QEELEAMLKSETWLSGAEAVEKGFADSLEPELQAAACVNQNKLKDYQNMPEQVNALFAPR HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCC AETQVTPLQASQPPAPQVSQDTPQPGAVDIAALATQLQQQMQAANAERVNAVSAVFDAFP CCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH AFASLKAECLSDFTCSAEKARERLLQALAAGTTPCAGPGAAHIYAGNGNLVGDSIRAAVM HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECHHHHHHHH ARAGYSEAEKDNAYNGFTLRELARASLVDRGIGISGHAAPMAMVGLAFTHSGSDFGNILM HHCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCHHHHHHH DVAHKAALQGWGSASETFDQWTRKGTLSDFKTAHRVGLEAFPTLRQVQPGAEYKYVTLKD HHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCHHHCCHHHHCCCCCCEEEEEEEC RGEPIALATYGELFSIDRQTIINDDLDMLTRIPMAMGAAARTTVGDLVWAVLTSNPKMSD CCCEEEEEECHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC GKPLFHADHGNLVTADLSIEGLDAGRKAMLLQKSGSRRLNIRPAFMLTPVAIESRASQLI CCCEEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCEEEECCEEEECCHHHHHHHHHHH KSSSVPGADANSGIVNPIQNFATVLSEARLDDSSPTDYYLVAAQGRDTIEVAYLDGIDTP HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCC YLEQQQGFTVDGAAFKVRIDAGVAPLDWRGMVKVKKQ CCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEECC >Mature Secondary Structure MIPSKRLQHGGPFFVVEQEQKPSGSVPEGSHRRRSNASECVKPNLTDKTGWCSILTPPTI CCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHCCCHHHHCCCCCCCCCCEEEECCCCCH KECSLMQQMISPPCRGMTINPRASLAGVDAANGQCWYEIRAQATGRVEIFLYDVIGGWGI HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCEEEEEEEECCCCEEEEEEEEECCCCCC TAQQFITDCKDAGVFEASAIDLHIHSPGGDVMQGFAIFNTLSRLKAKVDIWVDGVAASMA CHHHHHHHHHCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHEEEEEEECHHHHHHH SMIVCLPGATVHMPENAWIMVHKPWGGIAGDSDDMRDYADWLDRNEALMLSAYMNKTGLG HHEEECCCCEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHCCCCCC QEELEAMLKSETWLSGAEAVEKGFADSLEPELQAAACVNQNKLKDYQNMPEQVNALFAPR HHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHCCCC AETQVTPLQASQPPAPQVSQDTPQPGAVDIAALATQLQQQMQAANAERVNAVSAVFDAFP CCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH AFASLKAECLSDFTCSAEKARERLLQALAAGTTPCAGPGAAHIYAGNGNLVGDSIRAAVM HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEECHHHHHHHH ARAGYSEAEKDNAYNGFTLRELARASLVDRGIGISGHAAPMAMVGLAFTHSGSDFGNILM HHCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEEEECCCCHHHHHHH DVAHKAALQGWGSASETFDQWTRKGTLSDFKTAHRVGLEAFPTLRQVQPGAEYKYVTLKD HHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHCHHHCCHHHHCCCCCCEEEEEEEC RGEPIALATYGELFSIDRQTIINDDLDMLTRIPMAMGAAARTTVGDLVWAVLTSNPKMSD CCCEEEEEECHHHHHCCCHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC GKPLFHADHGNLVTADLSIEGLDAGRKAMLLQKSGSRRLNIRPAFMLTPVAIESRASQLI CCCEEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCEEEECCEEEECCHHHHHHHHHHH KSSSVPGADANSGIVNPIQNFATVLSEARLDDSSPTDYYLVAAQGRDTIEVAYLDGIDTP HHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEECCCCCC YLEQQQGFTVDGAAFKVRIDAGVAPLDWRGMVKVKKQ CCCCCCCCEECCCEEEEEEECCCCCCCCCCCEEEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11481430 [H]