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The map label for this gene is thiL [H]

Identifier: 218549923

GI number: 218549923

Start: 2678776

End: 2679753

Strand: Reverse

Name: thiL [H]

Synonym: EFER_2608

Alternate gene names: 218549923

Gene position: 2679753-2678776 (Counterclockwise)

Preceding gene: 218549924

Following gene: 218549922

Centisome position: 58.4

GC content: 51.53

Gene sequence:

>978_bases
ATGGCATGTGGCGAGTTCTCCCTGATTGCCCGTTATTTTGACCGTGTAAGAAGCTCTCGTCTTGATGTCGAGTTGGGCAT
TGGCGACGATTGCGCTCTTCTCAATATCCCCGAGAAACAGACCCTGGCAATCAGCACTGATACGCTGGTCGCGGGTAACC
ACTTCCTTGCAGATATCGATCCGGCCGATCTGGCATATAAAGCATTAGCTGTAAACCTAAGTGATCTGGCGGCGATGGGC
GCAGATCCAGCCTGGCTGACGCTGGCATTGACACTACCGGAAGTTGACGAAGCGTGGCTGGAGGCATTTAGTGATAGCCT
GTTTGATCAGCTGAATTATTATGATATGCAGCTGATTGGTGGCGATACCACACGTGGTCCGCTGTCTATGACGCTGGGTA
TTCACGGTTATGTGCCGATGGGGCGTGCGTTGACTCGTTCTGGCGCAAAGCCAGGTGACTGGATCTATGTGACGGGAACA
CCGGGTGATAGCGCCGCCGGGCTGGCGATTTTACAAAATCGCTTAACTCTCTCTGACGCGCAAGATGCTAACTATCTGTT
ACAACGCCATTTACGTCCTACTCCACGCATTTTACACGGGCAGGCGTTACGCGATCTGGCAAGTGCGGCAATCGATCTTT
CTGATGGTCTGATTTCTGACTTAGGCCATATTGTTAATGCCAGTGGCTGCGGAGCATGTATCGATGTTCAGGCTCTTCCA
TTGTCTGAAGCGATGATGCGTCATGTTGATCCTGAACAGGCGTTACGCTGGGCCATTTCGGGGGGTGAAGATTACGAATT
ATGTTTCACCGTACCAGAACTGAATCGTGGCGCACTGGATGTTGCACTGGCAAATTTGGGTGCACCATTTACCTGTATCG
GGCAGATGAGCGCAGATGTGGAAGGCGTCAATTTTACCCGTGACGGCGAACCTGTCACGTTTGACTGGAAAGGATATGAC
CATTTTGCCACGCCATAA

Upstream 100 bases:

>100_bases
TGATTCGCCCTAACAAAAAGTGATATCCAGGCCGGTAGAGTAGCGGAAAATTTATCCGTACTCCCCGGCCTTTTCTTTTT
TACCTGCTGAGGCATAACGT

Downstream 100 bases:

>100_bases
AGATGTCGCGAAAAGTCGCCTGAAGATGAGTAATCCGTGGCATCTGCTTGCTGTCGGATTCGGAAGTGGATTAAGCCCGA
TTGTTCCTGGTACGATGGGA

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLADIDPADLAYKALAVNLSDLAAMG
ADPAWLTLALTLPEVDEAWLEAFSDSLFDQLNYYDMQLIGGDTTRGPLSMTLGIHGYVPMGRALTRSGAKPGDWIYVTGT
PGDSAAGLAILQNRLTLSDAQDANYLLQRHLRPTPRILHGQALRDLASAAIDLSDGLISDLGHIVNASGCGACIDVQALP
LSEAMMRHVDPEQALRWAISGGEDYELCFTVPELNRGALDVALANLGAPFTCIGQMSADVEGVNFTRDGEPVTFDWKGYD
HFATP

Sequences:

>Translated_325_residues
MACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLADIDPADLAYKALAVNLSDLAAMG
ADPAWLTLALTLPEVDEAWLEAFSDSLFDQLNYYDMQLIGGDTTRGPLSMTLGIHGYVPMGRALTRSGAKPGDWIYVTGT
PGDSAAGLAILQNRLTLSDAQDANYLLQRHLRPTPRILHGQALRDLASAAIDLSDGLISDLGHIVNASGCGACIDVQALP
LSEAMMRHVDPEQALRWAISGGEDYELCFTVPELNRGALDVALANLGAPFTCIGQMSADVEGVNFTRDGEPVTFDWKGYD
HFATP
>Mature_324_residues
ACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLADIDPADLAYKALAVNLSDLAAMGA
DPAWLTLALTLPEVDEAWLEAFSDSLFDQLNYYDMQLIGGDTTRGPLSMTLGIHGYVPMGRALTRSGAKPGDWIYVTGTP
GDSAAGLAILQNRLTLSDAQDANYLLQRHLRPTPRILHGQALRDLASAAIDLSDGLISDLGHIVNASGCGACIDVQALPL
SEAMMRHVDPEQALRWAISGGEDYELCFTVPELNRGALDVALANLGAPFTCIGQMSADVEGVNFTRDGEPVTFDWKGYDH
FATP

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=325, Percent_Identity=88.6153846153846, Blast_Score=593, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 34914; Mature: 34783

Theoretical pI: Translated: 4.17; Mature: 4.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLADID
CCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCEEEEECCEEEECCCEEECCC
PADLAYKALAVNLSDLAAMGADPAWLTLALTLPEVDEAWLEAFSDSLFDQLNYYDMQLIG
HHHHHHHHHEECHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEC
GDTTRGPLSMTLGIHGYVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLTLSDA
CCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCC
QDANYLLQRHLRPTPRILHGQALRDLASAAIDLSDGLISDLGHIVNASGCGACIDVQALP
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECC
LSEAMMRHVDPEQALRWAISGGEDYELCFTVPELNRGALDVALANLGAPFTCIGQMSADV
HHHHHHHCCCHHHHHEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCC
EGVNFTRDGEPVTFDWKGYDHFATP
CCCEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
ACGEFSLIARYFDRVRSSRLDVELGIGDDCALLNIPEKQTLAISTDTLVAGNHFLADID
CCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCEEEEECCEEEECCCEEECCC
PADLAYKALAVNLSDLAAMGADPAWLTLALTLPEVDEAWLEAFSDSLFDQLNYYDMQLIG
HHHHHHHHHEECHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEC
GDTTRGPLSMTLGIHGYVPMGRALTRSGAKPGDWIYVTGTPGDSAAGLAILQNRLTLSDA
CCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHCCCCCCCC
QDANYLLQRHLRPTPRILHGQALRDLASAAIDLSDGLISDLGHIVNASGCGACIDVQALP
CHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECC
LSEAMMRHVDPEQALRWAISGGEDYELCFTVPELNRGALDVALANLGAPFTCIGQMSADV
HHHHHHHCCCHHHHHEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEECCCCCC
EGVNFTRDGEPVTFDWKGYDHFATP
CCCEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]