Click here to switch to the map view.

The map label for this gene is acrR [H]

Identifier: 218549868

GI number: 218549868

Start: 2618068

End: 2618715

Strand: Reverse

Name: acrR [H]

Synonym: EFER_2553

Alternate gene names: 218549868

Gene position: 2618715-2618068 (Counterclockwise)

Preceding gene: 218549875

Following gene: 218549867

Centisome position: 57.07

GC content: 45.52

Gene sequence:

>648_bases
ATGGCACGAAAAACCAAACAACAAGCGCTGGAAACACGACAGCACATCCTCGATGTAGCTTTGCGTTTGTTTTCTCAGCA
AGGAGTATCATCTACCTCGCTGGCAGAGATTGCAAAAGCCGCAGGCGTTACGCGTGGTGCAATCTACTGGCATTTTAAAA
ACAAGTCGGATTTGTTCAGTGAGATCTGGGAGTTGTCCGAGTCCAGTATCGGAGAACTTGAGCTTGAGTATCAGGCAAAA
TTCCCCGACGATCCACTTTCCGTTTTGCGAGAGATTTTAGTCTATATTCTTGAAGCTACTGTGACGGAAGAACGCCGACG
TTTATTGATGGAAATTATATTCCATAAATGTGAGTTCGTTGGTGAAATGGCGGTAGTTCAGCAGGCTCAGCGCAATCTCT
GCGTGGAAAGCTATGACCGTATCGAACAAACACTAAGACATTGTATTACTGCGAAAATGTTGCCAGAAGACCTGCTTACT
CGCCGGGCGGCTATTATTATGCGCGGCTATATTTCAGGTTTAATGGAAAGCTGGTTATTTGCTCCGCAGGCTTTTGACCT
GAAAAAAGAGGCGCGAGATTACGTCGCCGTCTTATTAGAAATGTATCTCTTTTGTCCATCACTGCGGGCAACCTCTGCAA
AGGAATAA

Upstream 100 bases:

>100_bases
AAAAGCCCCTAAACCCATTGCTGCGTTTATATTATCGTCGTGATATGGTACATACATTCATAAATGTATGTAAATCTAAC
GCCTGAAAATTCACTGACAT

Downstream 100 bases:

>100_bases
TGACACGCTAATTCCAGGATTTATCCTGGAGGATCTCGCTGTTGCTATTCCGTCTGTCTGAGGCGTGATATTCTTGCGCC
CTGACTATTTCCGGCGCCCC

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MARKTKQQALETRQHILDVALRLFSQQGVSSTSLAEIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESSIGELELEYQAK
FPDDPLSVLREILVYILEATVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCVESYDRIEQTLRHCITAKMLPEDLLT
RRAAIIMRGYISGLMESWLFAPQAFDLKKEARDYVAVLLEMYLFCPSLRATSAKE

Sequences:

>Translated_215_residues
MARKTKQQALETRQHILDVALRLFSQQGVSSTSLAEIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESSIGELELEYQAK
FPDDPLSVLREILVYILEATVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCVESYDRIEQTLRHCITAKMLPEDLLT
RRAAIIMRGYISGLMESWLFAPQAFDLKKEARDYVAVLLEMYLFCPSLRATSAKE
>Mature_214_residues
ARKTKQQALETRQHILDVALRLFSQQGVSSTSLAEIAKAAGVTRGAIYWHFKNKSDLFSEIWELSESSIGELELEYQAKF
PDDPLSVLREILVYILEATVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCVESYDRIEQTLRHCITAKMLPEDLLTR
RAAIIMRGYISGLMESWLFAPQAFDLKKEARDYVAVLLEMYLFCPSLRATSAKE

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=215, Percent_Identity=88.3720930232558, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789664, Length=204, Percent_Identity=38.2352941176471, Blast_Score=137, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24755; Mature: 24624

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQQALETRQHILDVALRLFSQQGVSSTSLAEIAKAAGVTRGAIYWHFKNKSDLFS
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
EIWELSESSIGELELEYQAKFPDDPLSVLREILVYILEATVTEERRRLLMEIIFHKCEFV
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMAVVQQAQRNLCVESYDRIEQTLRHCITAKMLPEDLLTRRAAIIMRGYISGLMESWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
APQAFDLKKEARDYVAVLLEMYLFCPSLRATSAKE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ARKTKQQALETRQHILDVALRLFSQQGVSSTSLAEIAKAAGVTRGAIYWHFKNKSDLFS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHH
EIWELSESSIGELELEYQAKFPDDPLSVLREILVYILEATVTEERRRLLMEIIFHKCEFV
HHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEMAVVQQAQRNLCVESYDRIEQTLRHCITAKMLPEDLLTRRAAIIMRGYISGLMESWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHC
APQAFDLKKEARDYVAVLLEMYLFCPSLRATSAKE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]