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The map label for this gene is tktB [C]

Identifier: 218549832

GI number: 218549832

Start: 2580748

End: 2581578

Strand: Reverse

Name: tktB [C]

Synonym: EFER_2515

Alternate gene names: 218549832

Gene position: 2581578-2580748 (Counterclockwise)

Preceding gene: 218549841

Following gene: 218549831

Centisome position: 56.26

GC content: 51.74

Gene sequence:

>831_bases
ATGAATCCCTATAGCTATGATATCCAGACCCTTGAGCGAAAAGCGCGGGCGGTACGCCGCCATATCGTGCGCTTAAATGC
CAATAGCCCGGCAGGTGGACACACCGGGGCCGATCTCTCTCAGGTTGAATTACTGACCGCACTCTATTTTCGTATACTCA
ATGTCGCCCCGGATCGCCTTCACGACGATGACCGGGATATATACATTCAGTCAAAAGGCCATGCTGTTGGATGTTACTAC
TGCGTGCTGGCGGAAGCAGGATTCTTCCCACTGGAATGGCTTTCCACTTATCAGCAGCCAAATTCACACTTACCCGGCCA
TCCGGTTCGGCAAAAAACGCCAGGTATTGAACTGAATACCGGAGCACTGGGGCATGGTTTCCCTGTGGCTGTAGGACTTG
CGCTGGCGGCGAAAAAAAGTCAAAGCCGTCGTCGTATCTTCTTAATTACTGGCGATGGTGAGCTGGCTGAGGGCAGTAAC
TGGGAAGCTGCACTGGCGGCGGCGCATTACGGGCTTGATAACCTGGTCATTATTAATGACAAAAATAATCTGCAATTAGC
CGGGCCAACGCGCGAAATCATGAACACCGATCCTCTGGCAGAGAAATGGCTGGCATTCGGTATGCAGGTTACTGAATGTC
AGGGCAATGATATGGCTTCGGTTGTCGCGACGCTTGAAGAGCTTAAACAGGAAGGCAAACCGAATGTGGTGATTGCCCAC
ACCACTAAAGGGGCAGGCATTTCCTTTATACAAGGGCGTGCGGAATGGCATCACCGGGTGCCGAAAGGCGATGAAATTGA
ACAGGCACTGGAGGAACTCAAAGATGCGTAA

Upstream 100 bases:

>100_bases
AGCAGCGTAAGTCTTGCCGCGCAACGCCCTGGGATTTCTGGTTTTTTTAGTCCCCGGTGGAATAAATATTCCATGTTGAA
AATAAATTCAGAGGTATTAA

Downstream 100 bases:

>100_bases
CAGTGAACATCTGGCAAATGTGATGGTTCAGGCGTTTATCGATGCCGTAAATGAGGGGATCGATTTGGTGCCTGTGGTGG
CTGATTCAACGTCTACGGCA

Product: transketolase N-terminal section (TK)

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MNPYSYDIQTLERKARAVRRHIVRLNANSPAGGHTGADLSQVELLTALYFRILNVAPDRLHDDDRDIYIQSKGHAVGCYY
CVLAEAGFFPLEWLSTYQQPNSHLPGHPVRQKTPGIELNTGALGHGFPVAVGLALAAKKSQSRRRIFLITGDGELAEGSN
WEAALAAAHYGLDNLVIINDKNNLQLAGPTREIMNTDPLAEKWLAFGMQVTECQGNDMASVVATLEELKQEGKPNVVIAH
TTKGAGISFIQGRAEWHHRVPKGDEIEQALEELKDA

Sequences:

>Translated_276_residues
MNPYSYDIQTLERKARAVRRHIVRLNANSPAGGHTGADLSQVELLTALYFRILNVAPDRLHDDDRDIYIQSKGHAVGCYY
CVLAEAGFFPLEWLSTYQQPNSHLPGHPVRQKTPGIELNTGALGHGFPVAVGLALAAKKSQSRRRIFLITGDGELAEGSN
WEAALAAAHYGLDNLVIINDKNNLQLAGPTREIMNTDPLAEKWLAFGMQVTECQGNDMASVVATLEELKQEGKPNVVIAH
TTKGAGISFIQGRAEWHHRVPKGDEIEQALEELKDA
>Mature_276_residues
MNPYSYDIQTLERKARAVRRHIVRLNANSPAGGHTGADLSQVELLTALYFRILNVAPDRLHDDDRDIYIQSKGHAVGCYY
CVLAEAGFFPLEWLSTYQQPNSHLPGHPVRQKTPGIELNTGALGHGFPVAVGLALAAKKSQSRRRIFLITGDGELAEGSN
WEAALAAAHYGLDNLVIINDKNNLQLAGPTREIMNTDPLAEKWLAFGMQVTECQGNDMASVVATLEELKQEGKPNVVIAH
TTKGAGISFIQGRAEWHHRVPKGDEIEQALEELKDA

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=274, Percent_Identity=32.1167883211679, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4507521, Length=274, Percent_Identity=32.1167883211679, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI133778974, Length=274, Percent_Identity=32.1167883211679, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI225637459, Length=256, Percent_Identity=26.953125, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI225637463, Length=174, Percent_Identity=31.6091954022989, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI225637461, Length=174, Percent_Identity=31.6091954022989, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1788808, Length=270, Percent_Identity=34.8148148148148, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI48994911, Length=255, Percent_Identity=31.3725490196078, Blast_Score=94, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17539652, Length=258, Percent_Identity=34.1085271317829, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319593, Length=272, Percent_Identity=31.25, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6325331, Length=252, Percent_Identity=31.7460317460317, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24666278, Length=269, Percent_Identity=33.0855018587361, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551847, Length=281, Percent_Identity=32.3843416370107, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI45550715, Length=281, Percent_Identity=32.3843416370107, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24645119, Length=239, Percent_Identity=33.4728033472803, Blast_Score=121, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 30323; Mature: 30323

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPYSYDIQTLERKARAVRRHIVRLNANSPAGGHTGADLSQVELLTALYFRILNVAPDRL
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
HDDDRDIYIQSKGHAVGCYYCVLAEAGFFPLEWLSTYQQPNSHLPGHPVRQKTPGIELNT
CCCCCEEEEEECCCEEEHHHEEEHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
GALGHGFPVAVGLALAAKKSQSRRRIFLITGDGELAEGSNWEAALAAAHYGLDNLVIIND
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEC
KNNLQLAGPTREIMNTDPLAEKWLAFGMQVTECQGNDMASVVATLEELKQEGKPNVVIAH
CCCEEECCCHHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
TTKGAGISFIQGRAEWHHRVPKGDEIEQALEELKDA
CCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNPYSYDIQTLERKARAVRRHIVRLNANSPAGGHTGADLSQVELLTALYFRILNVAPDRL
CCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHC
HDDDRDIYIQSKGHAVGCYYCVLAEAGFFPLEWLSTYQQPNSHLPGHPVRQKTPGIELNT
CCCCCEEEEEECCCEEEHHHEEEHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEECC
GALGHGFPVAVGLALAAKKSQSRRRIFLITGDGELAEGSNWEAALAAAHYGLDNLVIIND
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEEC
KNNLQLAGPTREIMNTDPLAEKWLAFGMQVTECQGNDMASVVATLEELKQEGKPNVVIAH
CCCEEECCCHHHHHCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEE
TTKGAGISFIQGRAEWHHRVPKGDEIEQALEELKDA
CCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]