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The map label for this gene is dxs [C]

Identifier: 218549831

GI number: 218549831

Start: 2579820

End: 2580866

Strand: Reverse

Name: dxs [C]

Synonym: EFER_2514

Alternate gene names: 218549831

Gene position: 2580866-2579820 (Counterclockwise)

Preceding gene: 218549832

Following gene: 218549828

Centisome position: 56.24

GC content: 53.01

Gene sequence:

>1047_bases
TTGCCCACACCACTAAAGGGGCAGGCATTTCCTTTATACAAGGGCGTGCGGAATGGCATCACCGGGTGCCGAAAGGCGAT
GAAATTGAACAGGCACTGGAGGAACTCAAAGATGCGTAACAGTGAACATCTGGCAAATGTGATGGTTCAGGCGTTTATCG
ATGCCGTAAATGAGGGGATCGATTTGGTGCCTGTGGTGGCTGATTCAACGTCTACGGCAAAAATTGCTCCCTTTATTAAG
CAATTTCCTGACCGACTGGTGAATGTGGGTATTGCCGAACAGAGTATGGTTGGTACAGCTGCCGGGCTGGCGCTGGGCGG
CAAGGTGGCTGTTACTTGCAATGCCGCGCCGTTTCTTATCGCTCGCGCTAACGAGCAAATCAAGGTTGATGTCTGCTACA
ACTTTACCAACGTAAAATTGTTCGGTCTGAATGCCGGGGCGAGTTATGGACCGCTAGCGAGCACGCATCATGCGATTGAT
GACATTGCGGTTATGCGTGGTTTCGGCAATATCCAGATCTTTGCCCCGTCTTCACCGCTGGAGTGCCGTCAGGTGATTGA
TTATGCCCTTCGCTATCAGGGACCTGTTTATATCCGTATGGACGGTAAAGCCCTGCCGGAAATCCACGATGAGGACTACC
GATTTGTGCCTGGTGCCGTGGTGACTTTACGCGAGGGCAGCGAACTGGCGCTGGTAGCCACAGGTTCTACCGTTCATGAA
GTGGTCGATGCCGCAGAACTTTTAGCGCAATCTGGTATCGCGGCTACAGTTGTCAGCGTACCGTCGATTCGCCCATGCGA
CACCAAAGCATTGCTGGCAGTGTTAAAAGGATGCAAAGCAGTGATGACGGTTGAAGAGCATAACGTCAATGGCGGCCTTG
GTAGCCTGGTCGCGGAAGTGTTGGCAGAGGCCGGAACGGGGATCAAATTAAAACGCGCGGGCATTATGGATGGAGAATAT
GCCGCAGCGGCGGATCGTGGGTGGTTGCGTCAGCATCATGGCTTTGATGCTGCCGGAATTGCAGCTCAGGCACGGGAAAT
GCTTTGA

Upstream 100 bases:

>100_bases
GCATTCGGTATGCAGGTTACTGAATGTCAGGGCAATGATATGGCTTCGGTTGTCGCGACGCTTGAAGAGCTTAAACAGGA
AGGCAAACCGAATGTGGTGA

Downstream 100 bases:

>100_bases
ATTATCCGCCAGACAACCCGCATGCGGCAGTGTGCGGGTGTTTATCTGCCCGGCACAAGGTAATAACGTTATTACCCCTT
ACTAACCACTGCACAATATG

Product: transketolase C-terminal section

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MPTPLKGQAFPLYKGVRNGITGCRKAMKLNRHWRNSKMRNSEHLANVMVQAFIDAVNEGIDLVPVVADSTSTAKIAPFIK
QFPDRLVNVGIAEQSMVGTAAGLALGGKVAVTCNAAPFLIARANEQIKVDVCYNFTNVKLFGLNAGASYGPLASTHHAID
DIAVMRGFGNIQIFAPSSPLECRQVIDYALRYQGPVYIRMDGKALPEIHDEDYRFVPGAVVTLREGSELALVATGSTVHE
VVDAAELLAQSGIAATVVSVPSIRPCDTKALLAVLKGCKAVMTVEEHNVNGGLGSLVAEVLAEAGTGIKLKRAGIMDGEY
AAAADRGWLRQHHGFDAAGIAAQAREML

Sequences:

>Translated_348_residues
MPTPLKGQAFPLYKGVRNGITGCRKAMKLNRHWRNSKMRNSEHLANVMVQAFIDAVNEGIDLVPVVADSTSTAKIAPFIK
QFPDRLVNVGIAEQSMVGTAAGLALGGKVAVTCNAAPFLIARANEQIKVDVCYNFTNVKLFGLNAGASYGPLASTHHAID
DIAVMRGFGNIQIFAPSSPLECRQVIDYALRYQGPVYIRMDGKALPEIHDEDYRFVPGAVVTLREGSELALVATGSTVHE
VVDAAELLAQSGIAATVVSVPSIRPCDTKALLAVLKGCKAVMTVEEHNVNGGLGSLVAEVLAEAGTGIKLKRAGIMDGEY
AAAADRGWLRQHHGFDAAGIAAQAREML
>Mature_347_residues
PTPLKGQAFPLYKGVRNGITGCRKAMKLNRHWRNSKMRNSEHLANVMVQAFIDAVNEGIDLVPVVADSTSTAKIAPFIKQ
FPDRLVNVGIAEQSMVGTAAGLALGGKVAVTCNAAPFLIARANEQIKVDVCYNFTNVKLFGLNAGASYGPLASTHHAIDD
IAVMRGFGNIQIFAPSSPLECRQVIDYALRYQGPVYIRMDGKALPEIHDEDYRFVPGAVVTLREGSELALVATGSTVHEV
VDAAELLAQSGIAATVVSVPSIRPCDTKALLAVLKGCKAVMTVEEHNVNGGLGSLVAEVLAEAGTGIKLKRAGIMDGEYA
AAADRGWLRQHHGFDAAGIAAQAREML

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=235, Percent_Identity=29.3617021276596, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4507521, Length=235, Percent_Identity=29.3617021276596, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI133778974, Length=223, Percent_Identity=29.5964125560538, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI225637459, Length=223, Percent_Identity=26.9058295964126, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI225637461, Length=224, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI225637463, Length=223, Percent_Identity=26.9058295964126, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786622, Length=273, Percent_Identity=31.1355311355311, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17539652, Length=243, Percent_Identity=30.4526748971193, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24666278, Length=225, Percent_Identity=27.5555555555556, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24645119, Length=223, Percent_Identity=29.1479820627803, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551847, Length=223, Percent_Identity=29.1479820627803, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45550715, Length=223, Percent_Identity=29.1479820627803, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 37003; Mature: 36872

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPLKGQAFPLYKGVRNGITGCRKAMKLNRHWRNSKMRNSEHLANVMVQAFIDAVNEGI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
DLVPVVADSTSTAKIAPFIKQFPDRLVNVGIAEQSMVGTAAGLALGGKVAVTCNAAPFLI
EEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCEEEEEECCCCEEE
ARANEQIKVDVCYNFTNVKLFGLNAGASYGPLASTHHAIDDIAVMRGFGNIQIFAPSSPL
EECCCEEEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCH
ECRQVIDYALRYQGPVYIRMDGKALPEIHDEDYRFVPGAVVTLREGSELALVATGSTVHE
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEECCCEEEEEECCCHHHH
VVDAAELLAQSGIAATVVSVPSIRPCDTKALLAVLKGCKAVMTVEEHNVNGGLGSLVAEV
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LAEAGTGIKLKRAGIMDGEYAAAADRGWLRQHHGFDAAGIAAQAREML
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PTPLKGQAFPLYKGVRNGITGCRKAMKLNRHWRNSKMRNSEHLANVMVQAFIDAVNEGI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
DLVPVVADSTSTAKIAPFIKQFPDRLVNVGIAEQSMVGTAAGLALGGKVAVTCNAAPFLI
EEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHEECCEEEEEECCCCEEE
ARANEQIKVDVCYNFTNVKLFGLNAGASYGPLASTHHAIDDIAVMRGFGNIQIFAPSSPL
EECCCEEEEEEEEEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCH
ECRQVIDYALRYQGPVYIRMDGKALPEIHDEDYRFVPGAVVTLREGSELALVATGSTVHE
HHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEECCCEEEEEECCCHHHH
VVDAAELLAQSGIAATVVSVPSIRPCDTKALLAVLKGCKAVMTVEEHNVNGGLGSLVAEV
HHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHH
LAEAGTGIKLKRAGIMDGEYAAAADRGWLRQHHGFDAAGIAAQAREML
HHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]