Click here to switch to the map view.

The map label for this gene is yegH

Identifier: 218549478

GI number: 218549478

Start: 2179340

End: 2180923

Strand: Direct

Name: yegH

Synonym: EFER_2147

Alternate gene names: 218549478

Gene position: 2179340-2180923 (Clockwise)

Preceding gene: 218549440

Following gene: 218549480

Centisome position: 47.49

GC content: 53.09

Gene sequence:

>1584_bases
ATGGAATGGATTGCCGATCCGTCTATCTGGGCCGGGTTAATCACGCTGATTGTGATCGAACTGGTCCTCGGCATTGATAA
CCTGGTCTTTATTGCCATCCTCGCCGAAAAACTACCGCCGAAGCAGCGCGACCGCGCACGGGTTACCGGGCTGCTGCTGG
CAATGTTAATGCGCCTGTTACTGCTGGCGTCAATCTCCTGGCTGGTCACCCTGACTCAACCACTGTTCAGCTTCCGCTCG
TTTACCTTTAGCGCCCGCGACTTAATCATGCTGTTTGGTGGGTTCTTCCTGTTGTTCAAAGCCACGATGGAGTTGAACGA
ACGGCTGGAGGGGAAAGACAGCAATAACCCCACGCAACGCAAAGGTGCGAAGTTCTGGGGCGTGGTGACGCAAATTGTGG
TGCTGGACGCCATCTTCTCACTCGACTCGGTGATTACCGCCGTCGGGATGGTCGACCATTTACTGGTAATGATGGCCGCC
GTCGTTATCGCTATCAGCCTGATGCTGATGGCAAGCAAGCCGTTAACCCAGTTCGTTAATAGCCACCCGACGATCGTTAT
TCTCTGCCTAAGTTTCCTGTTGATGATTGGCTTTAGCCTGGTGGCGGAAGGTTTCGGCTTCGTCATTCCGAAAGGCTATC
TGTATGCTGCCATTGGTTTCTCGGTGATGATCGAGGCGCTCAATCAGTTGGCTATCTTTAACCGGCGACGTTTTCTTTCC
GCTAACCAGACACTGCGCCAGCGGACTACCGAAGCGGTAATGCGCCTGCTTAGCGGGCAAAAAGAAGATGCGGAACTGGA
CGCCGAAACCGCGTCCATGCTGGTGGATCATGGTAACCAGCAGATCTTTAATCCGCAGGAACGGCGGATGATTGAGCGGG
TACTTAATCTTAACCAGCGTACTGTCAGCAGCATCATGACGTCACGCCACGATATTGAGCATATCGATCTCAACGCGCCA
GAAGAGGAGATCCGCCAGCTGCTGGAGCGAAATCAGCACACGCGTCTGGTCGTTACCGACGGCGATGATGCAGAAGATTT
GCTCGGTGTCGTTCACGTTATCGACCTGCTACAACAATCGCTGCGCGGCGAGCCTCTCAACCTGCGGGTGTTGATTCGCC
AGCCGCTGGTGTTCCCGGAAACCTTGCCGCTGTTACCTGCTCTCGAGCAGTTCCGTAATGCCCGCACACACTTTGCTTTT
GTGGTGGATGAGTTTGGCTCGGTGGAAGGGATTGTGACATTAAGTGACGTCACTGAAACCATTGCAGGTAACTTGCCAAA
CGAAGTGGAAGAGATCGATGCCCGTCATGATATTCAGAAAAATGCCGACGGTTCCTGGACAGCGAATGGTCATATGCCGC
TGGAAGATCTGGTGCAATATGTGCCGCTGCCGCTGGATGAAAAACGTGAATATCACACCATTGCCGGGCTGCTGATGGAA
TATTTACAGCGTATTCCAAAACCTGGCGAAGAAGTTCAGGTGGGGGATTATTTGCTTAAAACGTTGCAGGTGGAAAGCCA
TCGCGTACAGAAGGTGCAGATTATTCCGCTGCGTAAGGATGGCGAGATGGAGTACGAGGTGTGA

Upstream 100 bases:

>100_bases
AAAGTCAGATAAAAAGTGCTGTGACATTGCATTTTTTCCCTGATTTATCCATGATCGAATTGTGACATTTGTCATACAAC
GAATAGGTTTTGTACTTACT

Downstream 100 bases:

>100_bases
TGGTATCGGCCATTTTACCCAATGCTGCGTAACGCCTTATAACTTCAGCAATGAAGCGTTGTCTGTGGTACATGGACATC
ACAGCGGGGGTGTGGGTCCG

Product: membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MEWIADPSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQPLFSFRS
FTFSARDLIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAA
VVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANQTLRQRTTEAVMRLLSGQKEDAELDAETASMLVDHGNQQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EEEIRQLLERNQHTRLVVTDGDDAEDLLGVVHVIDLLQQSLRGEPLNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDARHDIQKNADGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEMEYEV

Sequences:

>Translated_527_residues
MEWIADPSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQPLFSFRS
FTFSARDLIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAA
VVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANQTLRQRTTEAVMRLLSGQKEDAELDAETASMLVDHGNQQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EEEIRQLLERNQHTRLVVTDGDDAEDLLGVVHVIDLLQQSLRGEPLNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDARHDIQKNADGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEMEYEV
>Mature_527_residues
MEWIADPSIWAGLITLIVIELVLGIDNLVFIAILAEKLPPKQRDRARVTGLLLAMLMRLLLLASISWLVTLTQPLFSFRS
FTFSARDLIMLFGGFFLLFKATMELNERLEGKDSNNPTQRKGAKFWGVVTQIVVLDAIFSLDSVITAVGMVDHLLVMMAA
VVIAISLMLMASKPLTQFVNSHPTIVILCLSFLLMIGFSLVAEGFGFVIPKGYLYAAIGFSVMIEALNQLAIFNRRRFLS
ANQTLRQRTTEAVMRLLSGQKEDAELDAETASMLVDHGNQQIFNPQERRMIERVLNLNQRTVSSIMTSRHDIEHIDLNAP
EEEIRQLLERNQHTRLVVTDGDDAEDLLGVVHVIDLLQQSLRGEPLNLRVLIRQPLVFPETLPLLPALEQFRNARTHFAF
VVDEFGSVEGIVTLSDVTETIAGNLPNEVEEIDARHDIQKNADGSWTANGHMPLEDLVQYVPLPLDEKREYHTIAGLLME
YLQRIPKPGEEVQVGDYLLKTLQVESHRVQKVQIIPLRKDGEMEYEV

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI310128564, Length=316, Percent_Identity=24.0506329113924, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI87082033, Length=527, Percent_Identity=100, Blast_Score=1067, Evalue=0.0,
Organism=Escherichia coli, GI1788119, Length=520, Percent_Identity=50.1923076923077, Blast_Score=461, Evalue=1e-131,
Organism=Escherichia coli, GI1789197, Length=226, Percent_Identity=51.3274336283186, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1790664, Length=238, Percent_Identity=32.3529411764706, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI145693175, Length=277, Percent_Identity=27.4368231046931, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=27.6264591439689, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YEGH_ECOLI (P76389)

Other databases:

- EMBL:   U00096
- EMBL:   AP009048
- PIR:   F64972
- RefSeq:   AP_002663.1
- RefSeq:   NP_416567.4
- ProteinModelPortal:   P76389
- DIP:   DIP-11879N
- EnsemblBacteria:   EBESCT00000001879
- EnsemblBacteria:   EBESCT00000014409
- GeneID:   946566
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW5336
- KEGG:   eco:b2063
- EchoBASE:   EB3804
- EcoGene:   EG14051
- eggNOG:   COG1253
- GeneTree:   EBGT00050000010862
- HOGENOM:   HBG470183
- OMA:   TMEWIAD
- ProtClustDB:   CLSK866497
- BioCyc:   EcoCyc:G7108-MONOMER
- Genevestigator:   P76389
- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005496
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10
- SMART:   SM00116

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF03741 TerC

EC number: NA

Molecular weight: Translated: 59451; Mature: 59451

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x293a8c48)-; HASH(0x28d68738)-; HASH(0x29ca45d0)-; HASH(0x2a0186a4)-; HASH(0x2a3a9cd0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCH
>Mature Secondary Structure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HHHHCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503