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The map label for this gene is rnb [H]

Identifier: 218549019

GI number: 218549019

Start: 1713463

End: 1715397

Strand: Direct

Name: rnb [H]

Synonym: EFER_1667

Alternate gene names: 218549019

Gene position: 1713463-1715397 (Clockwise)

Preceding gene: 218549018

Following gene: 218549020

Centisome position: 37.34

GC content: 50.65

Gene sequence:

>1935_bases
ATGTTTCAGGACAACCCGCTGCTAGCGCAGCTAAAACAGCAACTTCATTCCCAGACGCCACGTGCTGAAGGGGTGGTAAA
AGCCACCGAAAAAGGCTTTGGCTTCCTGGAAGTCGATGCACAAAAAAGTTATTTCATCCCACCGCCGCAAATGAAAAAAG
TTATGCACGGCGATCGGATAATTGCAGTGATCCATAGCGAAAAAGATCGCGAATCTGCGGAGCCGGAAGAACTGGTCGAA
CCGTTCCTGACTCGCTTTGTGGGCAAAGTTCAGGGCAAAAATGATCGTTTGTCTATTGTGCCTGACCATCCGTTATTGAA
AGATGCCATTCCTTGCCGTGCGGCACGTGGTGTTGATCATCAATTCAAAGAAGGCGACTGGGCAGTTGCGGAAATGCGCC
GCCATCCGCTGAAAGGCGATCGCTCTTTCTACGCCGAATTAACCCAATTTATTACTTTTGGTGATGACCACTTTGTACCG
TGGTGGGTCACCCTCGCCCGCCATAATCTTGAACGTGAAGCACCAAACGGCGTGGCAACCGAAATGCTTGATGAAGGTCT
GGTGCGTCAGGATTTGACCGCCCTTAACTTTGTCACTATCGATAGCGCCAGCACTGAAGACATGGATGATGCGCTGTATG
CTGAAGCACTACCTGATGGCAAACTGCAATTAACAGTCGCAATTGCAGATCCTACTGCCTGGATTGCTGAAGGCAGCAAG
CTGGATAACGTGGCAAAAATTCGCGCGTTTACCAACTACTTGCCGGGCTTCAATATTCCCATGTTGCCGCGCGAATTGTC
TGACGATCTTTGCTCACTGCGTGCATTTGAAGTTCGCCCGGCGCTGGCATGCCGGATGACTATCGCCGCAGATGGCACCA
TCGAAGACGATATTGAATTCTTTGCTGCAACTATCGAGTCTAAAGCGAAACTGGTCTATGACGAGGTTTCTGACTGGCTG
GAAAACAGTGGGAATTGGCAACCGGAAAATGATGCCATTGCAGAACAAATCCGTCTGCTGGCGCAAATCTGCCAGCGTCG
CGGTGAGTGGCGTCATAACCATGCACTCGTATTTAAAGATCGTCCTGATTATCGCTTTATCCTGGGTGAAAAAGGCGAAG
TGCTGGATATCGTTGCAGAACCGCGTCGTATCGCCAACCGTATCGTTGAAGAAGCCATGATCGCAGCCAATATTTGTGCT
GCTCGAGTACTTCGCGACAAAATCGGTTTTGGGATCTACAACGTTCATATGGGCTTTGATCCCGCTAATGCTGATGCTCT
GGCTGCGCTGCTGAAAACTCACGGTCTGCACGTCGATGCGCAAGAAGTGCTGACTCTGGAAGGTTTTTGTAAACTGCGCC
GCGAACTGGATGCCCAACCGTCAGGTTTTCTTGACAGCCGTATTCGCCGTTTCCAGTCATTTGCTGAAATTAGTACTCAA
CCAGGGCCACATTTTGGCCTGGGGCTTGAGGCTTACGCCACCTGGACGTCACCTATTCGTAAATATGGCGACATGATCAA
CCATCGTTTACTGAAAGCGGCAATTAAAGGCGAAACTGCCAGCCGCCCTCAGGATGAAACGACTGTCCAAATGACCGAAC
GCCGTCGCCTTAACCGCATGGCTGAGCGTGATGTCGGTGACTGGCTGTATGCGCGATTCCTGAAAGATAAAGCGGGCACA
GACACTCGCTTCGCCGCAGAAATCATTGATATTAGCCGTGGTGGTATGCGTGTACGGTTGGTTGACAATGGTGCAGTTGC
ATTTATCCCTGCCCCTTTCCTGCACGCTGTTCGTGATGAACTGGTATGCAGTCAAGAGAACGGCACCGTGCAAATTAAAG
GCGAGACAGTGTACAAAGTGACAGATGTCATTGATGTCACCATCGCCGAAGTACGTATGGAAACCCGCAGCATTATTGCC
CGTCCGGTCGCCTGA

Upstream 100 bases:

>100_bases
CGATTAAAAATCGGCTTGGGTGAAACATATTAGCCTTGCCGCAACAGACAGAATCGCGTAAAACTGTCAGCCGCTCTTTT
GGCCACGAAAATAGACGAAT

Downstream 100 bases:

>100_bases
TATCATTACTGAACGGTCTTCTTCCAGTGGGAAGGCCGTTTAATTCCTCGTTCACTCCTCATTCCATAAGTTACACAAAA
CTATTTTTCCCCGTAACTAT

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKDRESAEPEELVE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDHQFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVP
WWVTLARHNLEREAPNGVATEMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSK
LDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEFFAATIESKAKLVYDEVSDWL
ENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKIGFGIYNVHMGFDPANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQ
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKDRESAEPEELVE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDHQFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVP
WWVTLARHNLEREAPNGVATEMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSK
LDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEFFAATIESKAKLVYDEVSDWL
ENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKIGFGIYNVHMGFDPANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQ
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRIIAVIHSEKDRESAEPEELVE
PFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDHQFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVP
WWVTLARHNLEREAPNGVATEMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSK
LDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEFFAATIESKAKLVYDEVSDWL
ENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKDRPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICA
ARVLRDKIGFGIYNVHMGFDPANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQ
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRMAERDVGDWLYARFLKDKAGT
DTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDELVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIA
RPVA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction [H]

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=359, Percent_Identity=27.2980501392758, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI190014625, Length=359, Percent_Identity=27.2980501392758, Blast_Score=122, Evalue=2e-27,
Organism=Homo sapiens, GI134288890, Length=366, Percent_Identity=28.9617486338798, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=94.0993788819876, Blast_Score=1248, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=649, Percent_Identity=26.1941448382126, Blast_Score=173, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI212645896, Length=468, Percent_Identity=26.2820512820513, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17553506, Length=408, Percent_Identity=26.2254901960784, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324552, Length=423, Percent_Identity=24.3498817966903, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24649634, Length=359, Percent_Identity=29.2479108635098, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI19922976, Length=431, Percent_Identity=28.7703016241299, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24654597, Length=431, Percent_Identity=28.7703016241299, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24654592, Length=431, Percent_Identity=28.7703016241299, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: =3.1.13.1 [H]

Molecular weight: Translated: 72426; Mature: 72426

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKDRESAEPEELVEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHCCCCC
QFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVPWWVTLARHNLEREAPNGVAT
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCCCCCHHH
EMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSK
HHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCC
LDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEF
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEEEECCCCHHHHHH
FAATIESKAKLVYDEVSDWLENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
RPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKIGFGIYNVHMGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQ
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AERDVGDWLYARFLKDKAGTDTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDE
HHHCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRAEGVVKATEKGFGFLEVDAQKSYFIPPPQMKKVMHGDRI
CCCCCHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEEECCCCCCCCCCHHHHHHHCCCEE
IAVIHSEKDRESAEPEELVEPFLTRFVGKVQGKNDRLSIVPDHPLLKDAIPCRAARGVDH
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHCCCHHHHCCCCC
QFKEGDWAVAEMRRHPLKGDRSFYAELTQFITFGDDHFVPWWVTLARHNLEREAPNGVAT
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHCCCCCHHH
EMLDEGLVRQDLTALNFVTIDSASTEDMDDALYAEALPDGKLQLTVAIADPTAWIAEGSK
HHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHCCCCCCEEEEEEEECCCHHHHCCCC
LDNVAKIRAFTNYLPGFNIPMLPRELSDDLCSLRAFEVRPALACRMTIAADGTIEDDIEF
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHEEEEEEEECCCCHHHHHH
FAATIESKAKLVYDEVSDWLENSGNWQPENDAIAEQIRLLAQICQRRGEWRHNHALVFKD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
RPDYRFILGEKGEVLDIVAEPRRIANRIVEEAMIAANICAARVLRDKIGFGIYNVHMGFD
CCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
PANADALAALLKTHGLHVDAQEVLTLEGFCKLRRELDAQPSGFLDSRIRRFQSFAEISTQ
CCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCC
PGPHFGLGLEAYATWTSPIRKYGDMINHRLLKAAIKGETASRPQDETTVQMTERRRLNRM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
AERDVGDWLYARFLKDKAGTDTRFAAEIIDISRGGMRVRLVDNGAVAFIPAPFLHAVRDE
HHHCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEECHHHHHHHHHH
LVCSQENGTVQIKGETVYKVTDVIDVTIAEVRMETRSIIARPVA
HHEECCCCEEEEECCEEEEEHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA