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The map label for this gene is ydhC [H]

Identifier: 218548745

GI number: 218548745

Start: 1420778

End: 1421983

Strand: Reverse

Name: ydhC [H]

Synonym: EFER_1384

Alternate gene names: 218548745

Gene position: 1421983-1420778 (Counterclockwise)

Preceding gene: 218548747

Following gene: 218548744

Centisome position: 30.99

GC content: 51.16

Gene sequence:

>1206_bases
ATGCAACCTGGGAAAGGATTTTTAGTCTGGCTGGCAGGTTTAAGCGTACTCGGTTTCCTGGCAACCGATATGTATTTACC
TGCTTTCGCCGCTATACAGGCAGATCTGCAAACCCCGGCTTCTGCCGTTAGTGCCAGTCTCAGTCTGTTTCTGGCGGGCT
TTGCCGTCGCGCAGCTGTTATGGGGACCGCTATCAGACCGTTATGGTCGTAAACCAATACTGCTGCTTGGCCTGACCATC
TTTGCCCTCGGAAGTTTGGGGATGCTGTGGGTCACTAACGCTGTAGGATTACTCGTTTTGCGCTTTATCCAGGCGATTGG
TGTCTGTGCCGCAGCGGTTATCTGGCAGGCACTGGTGACCGATTATTATCCTTCACAAAAAGTTAACCGTATTTTCGCCA
CGATTATGCCGCTGGTGGGGTTATCTCCTGCCCTGGCGCCGTTAGTGGGAAGCTGGCTACTGGTGCATTTTTCATGGCAA
TCCATTTTTGCCACGCTGTTTGCCATCACTGTCTTGTTGATGATTCCTGCTCTGCGCCTTAAACCTGCGCGTAAAAATCA
GGAAAATAAGCAGCAGTCACTCACTTTCACTACCCTGCTGCGTTCAAAGGCTTACCGTGGCAATGTGCTGATTTATGCAG
CGTGTTCTGCCAGCTTTTTCGCCTGGCTGACAGGTTCGCCATTCATTCTCAGTGAAATGGGTTACACCCCGGCGGTGATT
GGTTTGAGTTATGTTCCACAGACTATCGCTTTCCTGATTGGTGGTTATGGTTGCCGTGCGGCATTGCAGAAATGGCATGG
CCAGCAAATGTTGCCCTGGTTATTGGTACTGTTTGCGCTGAGCGTTATTGCCACCTGGGCGACCAGCTTTATCAATCACG
TTTCGCTGGTTGAAATTTTAATTCCGTTCTGTGTGATGGCGATTGCCAATGGTGCGATCTACCCGATTGTTGTGGCGCAG
GCGTTACGTCCGTTCCCGCAAGCGACCGGACGTGCAGCTGCGTTGCAAAATACTCTGCAGTTGGGATTATGCTTTCTCGC
AAGCCTGGTGGTTTCCTGGCTTATCAGCACCCCGTTACTGACCACAACCAGCGTGATGTTAGCCACTGTTGTGTTGGTTA
CTGTGGGCTATAAGATGCAAAGCCATGCAGAAACTGCGAACGAATGCTGTCAGCGTAGCGATATGGCACACGGTGAATCG
CACTGA

Upstream 100 bases:

>100_bases
AATTTTTGAAATCACCCGTCAAATATTAACGTTTCACAATCAGAATTTCACTCCCTACACTTTGCGCCGATGTCTTACTG
ATAACTACAGAGAATGAATT

Downstream 100 bases:

>100_bases
TAAATTGATATGATTTATGGATAGGTCGCTAAGATTTTTCTGTTGTATGAATGGTTTTTGCGGCCTATACTAATTTTCAG
TTGTTAAAAAAGACGATAAT

Product: inner membrane transport protein YdhC

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQPGKGFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAVAQLLWGPLSDRYGRKPILLLGLTI
FALGSLGMLWVTNAVGLLVLRFIQAIGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLVGSWLLVHFSWQ
SIFATLFAITVLLMIPALRLKPARKNQENKQQSLTFTTLLRSKAYRGNVLIYAACSASFFAWLTGSPFILSEMGYTPAVI
GLSYVPQTIAFLIGGYGCRAALQKWHGQQMLPWLLVLFALSVIATWATSFINHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPQATGRAAALQNTLQLGLCFLASLVVSWLISTPLLTTTSVMLATVVLVTVGYKMQSHAETANECCQRSDMAHGES
H

Sequences:

>Translated_401_residues
MQPGKGFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAVAQLLWGPLSDRYGRKPILLLGLTI
FALGSLGMLWVTNAVGLLVLRFIQAIGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLVGSWLLVHFSWQ
SIFATLFAITVLLMIPALRLKPARKNQENKQQSLTFTTLLRSKAYRGNVLIYAACSASFFAWLTGSPFILSEMGYTPAVI
GLSYVPQTIAFLIGGYGCRAALQKWHGQQMLPWLLVLFALSVIATWATSFINHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPQATGRAAALQNTLQLGLCFLASLVVSWLISTPLLTTTSVMLATVVLVTVGYKMQSHAETANECCQRSDMAHGES
H
>Mature_401_residues
MQPGKGFLVWLAGLSVLGFLATDMYLPAFAAIQADLQTPASAVSASLSLFLAGFAVAQLLWGPLSDRYGRKPILLLGLTI
FALGSLGMLWVTNAVGLLVLRFIQAIGVCAAAVIWQALVTDYYPSQKVNRIFATIMPLVGLSPALAPLVGSWLLVHFSWQ
SIFATLFAITVLLMIPALRLKPARKNQENKQQSLTFTTLLRSKAYRGNVLIYAACSASFFAWLTGSPFILSEMGYTPAVI
GLSYVPQTIAFLIGGYGCRAALQKWHGQQMLPWLLVLFALSVIATWATSFINHVSLVEILIPFCVMAIANGAIYPIVVAQ
ALRPFPQATGRAAALQNTLQLGLCFLASLVVSWLISTPLLTTTSVMLATVVLVTVGYKMQSHAETANECCQRSDMAHGES
H

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=403, Percent_Identity=85.6079404466501, Blast_Score=682, Evalue=0.0,
Organism=Escherichia coli, GI1788509, Length=347, Percent_Identity=29.971181556196, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87082312, Length=340, Percent_Identity=25.5882352941176, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790794, Length=225, Percent_Identity=27.5555555555556, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790146, Length=224, Percent_Identity=27.6785714285714, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1787065, Length=217, Percent_Identity=26.2672811059908, Blast_Score=83, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319657, Length=163, Percent_Identity=26.9938650306748, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=188, Percent_Identity=23.936170212766, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43285; Mature: 43285

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]