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The map label for this gene is adrB [H]

Identifier: 218548627

GI number: 218548627

Start: 1298501

End: 1300108

Strand: Reverse

Name: adrB [H]

Synonym: EFER_1261

Alternate gene names: 218548627

Gene position: 1300108-1298501 (Counterclockwise)

Preceding gene: 218548628

Following gene: 218548625

Centisome position: 28.33

GC content: 47.2

Gene sequence:

>1608_bases
GTGGCCCGCATGCAAAAAGCACAACGGATCATTAAAACCTATCGCCGTAATCGAATGATTGTTTGTACAATTTGCGCACT
CTTTACGCTTATCACTACATTAAGCGTACGATTTATTTCACAGCGGAACTTAAATCAGCAGCGGGTGGTGATGTTTGCTA
ATCATGCGGTGGAAGAGCTGGATAACGTCTTGTTTCCTTTGCAATCCGGACGTGATGTCTTGTTACAGTTGATTGGCCTG
CCCTGTTCAGTCAGCCATTTGCCTTTGCGCAAACAGGCAGCGAAGTTACAAACCGTGCGATCTATCGGTCTGGTGCAAAA
TGGTACGCTTTATTGTTCCAGTATTTTTGGCTACCGCAATGTCCCTGTCCGCGAGATTCAGACCGATTTACCAGCCAGGC
AGGCTTTACTTCGTTTGACGATAGATCACGTTCTCATTAAAGGCAGTCCGGTACTGATTCAATGGTATCCCTCTGCGGCT
AACGCGCAAGACGGGGTGCTGGAGATGATCAATATCGAGTTGTTAACGACAATGTTACTTGAGCCGCAGTCACCACAAAT
TACCAGCGCCACTCTGACAGTAGCTGATCGCCATTTGCTCTATGCCAATGGTATTGTGGATTCATTGCCACCCCTGAACG
ACGAAAGGCGCTATCAAGTTTCTTCGCACAATTTTCCTTTCACGATTAGTGTGGATGGCCCCGGCGCTACAGCGTTGGCA
CTTAAAAATCTCCCCTCACAATTACCTCTGGCGTTATTACTGAGTTTACTTGTGGGTTACATGACCTGGCTGGCGACGGC
CCATAGGATGAGTTTTTACCGTGAAATACATCTGGGTCTTGCACAGAGAGAGTTTGAACTGTTTTGCCAGCCTCTGCTTA
ATGCAAGGAGTCAGCAATGTATCGGCGTTGAAATTTTGTTGCGCTGGAATAATCCACGTCAGGGCTGGATTTCGCCAGAT
GTCTTTATCCCTATTGCGGAAGAACACCATTTAATTGTGCCACTGACTCGCTACGTGATGATGGAAACTATTCGTCAGCG
GCATGTATTTCCAATGAATAACCAGTTTCATATTGGTATTAACGTTGCCCCCAGTCACTTTCGCCGGGGGGTGTTATTAA
AAGATCTCAATCAATACTGGTTCAGTGCAAACCCGATTCAGCAGCTCATTCTCGAAATAACAGAGCGTGATGCTTTGCTG
GATGTGGATTACCGTATAGCACGTGAGTTGCATCGTAAAAATGTTAAGCTGGCAATTGATGATTTTGGTACGGGCAATAG
CTCGTTTTCCTGGCTGGAAACACTACGGCCGGATGTGTTGAAAATTGATAAATCATTCACCGCTGCAATTGGTTCAGATG
CCGTTAACTCTACGGTAACCGATATTATTATTGCCCTGGGGCAACGGCTAAATATTGAACTGGTGGCAGAAGGCGTGGAA
ACCCAACAACAGGCGAAGTATCTACGCCAGCACGGCGTACATATTTTGCAAGGTTATTTATATGCGCAGCCAATGCCACT
GCGCGATTTTCCCAAATGGCTGGCAGGAAGCCAGCCCCCGGGCACCCGGCATAACGGGCATGTTACCCCCGTCATGCCAT
TACGTTAG

Upstream 100 bases:

>100_bases
CAACGGATGGGCGAATTTACCCCTGCTTTCTCGTCTGCTGTAATTTTCCCCACTACACTTCCACTGTTGCGTCAGGCATT
TGTAGCCATACGCTTACAGG

Downstream 100 bases:

>100_bases
CGTTACTCGTCTTCGTCGTTGAGCGGTTTATCTTTAACAATACGAACCAAATCAACGCGATAGTCGTTAGCTTCAACAAT
AGTGATATGCAACGGTCCAA

Product: cyclic di-GMP phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MARMQKAQRIIKTYRRNRMIVCTICALFTLITTLSVRFISQRNLNQQRVVMFANHAVEELDNVLFPLQSGRDVLLQLIGL
PCSVSHLPLRKQAAKLQTVRSIGLVQNGTLYCSSIFGYRNVPVREIQTDLPARQALLRLTIDHVLIKGSPVLIQWYPSAA
NAQDGVLEMINIELLTTMLLEPQSPQITSATLTVADRHLLYANGIVDSLPPLNDERRYQVSSHNFPFTISVDGPGATALA
LKNLPSQLPLALLLSLLVGYMTWLATAHRMSFYREIHLGLAQREFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPD
VFIPIAEEHHLIVPLTRYVMMETIRQRHVFPMNNQFHIGINVAPSHFRRGVLLKDLNQYWFSANPIQQLILEITERDALL
DVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVE
TQQQAKYLRQHGVHILQGYLYAQPMPLRDFPKWLAGSQPPGTRHNGHVTPVMPLR

Sequences:

>Translated_535_residues
MARMQKAQRIIKTYRRNRMIVCTICALFTLITTLSVRFISQRNLNQQRVVMFANHAVEELDNVLFPLQSGRDVLLQLIGL
PCSVSHLPLRKQAAKLQTVRSIGLVQNGTLYCSSIFGYRNVPVREIQTDLPARQALLRLTIDHVLIKGSPVLIQWYPSAA
NAQDGVLEMINIELLTTMLLEPQSPQITSATLTVADRHLLYANGIVDSLPPLNDERRYQVSSHNFPFTISVDGPGATALA
LKNLPSQLPLALLLSLLVGYMTWLATAHRMSFYREIHLGLAQREFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPD
VFIPIAEEHHLIVPLTRYVMMETIRQRHVFPMNNQFHIGINVAPSHFRRGVLLKDLNQYWFSANPIQQLILEITERDALL
DVDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVE
TQQQAKYLRQHGVHILQGYLYAQPMPLRDFPKWLAGSQPPGTRHNGHVTPVMPLR
>Mature_534_residues
ARMQKAQRIIKTYRRNRMIVCTICALFTLITTLSVRFISQRNLNQQRVVMFANHAVEELDNVLFPLQSGRDVLLQLIGLP
CSVSHLPLRKQAAKLQTVRSIGLVQNGTLYCSSIFGYRNVPVREIQTDLPARQALLRLTIDHVLIKGSPVLIQWYPSAAN
AQDGVLEMINIELLTTMLLEPQSPQITSATLTVADRHLLYANGIVDSLPPLNDERRYQVSSHNFPFTISVDGPGATALAL
KNLPSQLPLALLLSLLVGYMTWLATAHRMSFYREIHLGLAQREFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDV
FIPIAEEHHLIVPLTRYVMMETIRQRHVFPMNNQFHIGINVAPSHFRRGVLLKDLNQYWFSANPIQQLILEITERDALLD
VDYRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVET
QQQAKYLRQHGVHILQGYLYAQPMPLRDFPKWLAGSQPPGTRHNGHVTPVMPLR

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=532, Percent_Identity=86.6541353383459, Blast_Score=931, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=520, Percent_Identity=28.6538461538462, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786507, Length=255, Percent_Identity=38.8235294117647, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI87081845, Length=531, Percent_Identity=28.6252354048964, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1790496, Length=246, Percent_Identity=33.739837398374, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081743, Length=517, Percent_Identity=27.2727272727273, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI87081921, Length=250, Percent_Identity=33.6, Blast_Score=131, Evalue=9e-32,
Organism=Escherichia coli, GI1787541, Length=232, Percent_Identity=31.4655172413793, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI226510982, Length=256, Percent_Identity=30.46875, Blast_Score=112, Evalue=8e-26,
Organism=Escherichia coli, GI87082096, Length=252, Percent_Identity=28.968253968254, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1787055, Length=253, Percent_Identity=30.4347826086957, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788849, Length=241, Percent_Identity=31.1203319502075, Blast_Score=100, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 60648; Mature: 60516

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMQKAQRIIKTYRRNRMIVCTICALFTLITTLSVRFISQRNLNQQRVVMFANHAVEEL
CCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHH
DNVLFPLQSGRDVLLQLIGLPCSVSHLPLRKQAAKLQTVRSIGLVQNGTLYCSSIFGYRN
HHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCEEEEECCCCCC
VPVREIQTDLPARQALLRLTIDHVLIKGSPVLIQWYPSAANAQDGVLEMINIELLTTMLL
CCHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHC
EPQSPQITSATLTVADRHLLYANGIVDSLPPLNDERRYQVSSHNFPFTISVDGPGATALA
CCCCCCCEEEEEEEECCEEEEECCCHHCCCCCCCCCCEEECCCCCCEEEEECCCCCHHHH
LKNLPSQLPLALLLSLLVGYMTWLATAHRMSFYREIHLGLAQREFELFCQPLLNARSQQC
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMMETIRQRHVFPMNNQFHIGI
EEEEEEEEECCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEE
NVAPSHFRRGVLLKDLNQYWFSANPIQQLILEITERDALLDVDYRIARELHRKNVKLAID
EECHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEE
DFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVE
CCCCCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
TQQQAKYLRQHGVHILQGYLYAQPMPLRDFPKWLAGSQPPGTRHNGHVTPVMPLR
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCC
>Mature Secondary Structure 
ARMQKAQRIIKTYRRNRMIVCTICALFTLITTLSVRFISQRNLNQQRVVMFANHAVEEL
CHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHH
DNVLFPLQSGRDVLLQLIGLPCSVSHLPLRKQAAKLQTVRSIGLVQNGTLYCSSIFGYRN
HHHHCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCEEEEECCCCCC
VPVREIQTDLPARQALLRLTIDHVLIKGSPVLIQWYPSAANAQDGVLEMINIELLTTMLL
CCHHHHHHCCHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHC
EPQSPQITSATLTVADRHLLYANGIVDSLPPLNDERRYQVSSHNFPFTISVDGPGATALA
CCCCCCCEEEEEEEECCEEEEECCCHHCCCCCCCCCCEEECCCCCCEEEEECCCCCHHHH
LKNLPSQLPLALLLSLLVGYMTWLATAHRMSFYREIHLGLAQREFELFCQPLLNARSQQC
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
IGVEILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTRYVMMETIRQRHVFPMNNQFHIGI
EEEEEEEEECCCCCCCCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEE
NVAPSHFRRGVLLKDLNQYWFSANPIQQLILEITERDALLDVDYRIARELHRKNVKLAID
EECHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEE
DFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVE
CCCCCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCC
TQQQAKYLRQHGVHILQGYLYAQPMPLRDFPKWLAGSQPPGTRHNGHVTPVMPLR
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]