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The map label for this gene is ypdF [H]

Identifier: 218548166

GI number: 218548166

Start: 799055

End: 800140

Strand: Direct

Name: ypdF [H]

Synonym: EFER_0783

Alternate gene names: 218548166

Gene position: 799055-800140 (Clockwise)

Preceding gene: 218548165

Following gene: 218548167

Centisome position: 17.41

GC content: 56.72

Gene sequence:

>1086_bases
ATGACATTACTCGCTTCGCTGCGCGACTGGCTTAAGGCGCAACAACTGGATGCGGTGCTTCTCTCCTCACGGCAGAACAA
ACAACCGCATCTGGGGATCTCCACCGGATCAGGCTATGTGGTGATTAGCCGTGAAAGTGCGCACATTCTGGTGGATTCGC
GCTATTACGCGGATGTAGAAGCCCGCACGCAAGGCTACCAGCTGCATTTGCTTGACGCGACGAACACGCTTACCACTATC
GTCAATCAAATCATTGCCGATGAGCAGTTGCAAACGCTCGGTTTTGAAGGCCAGCAGGTAAGTTGGGAAACCGCGCACCG
CTGGCAGTCTGAACTCAATGCGAAGCTGGTAAGCGCCACGCCGGATGTGCTGCGGCAAATCAAAACGCCAGAGGAGGTGG
AGAAAATCCGCCTCGCCTGTGGGATTGCCGATCGCGGTGCAGAGCATATTCGCCGCTTTATTCAGGCGGGGATGAGCGAA
TGCGAGATTGCTGCTGAACTGGAGTGGTTTATGCGCCAGCAGGGCGCAGAAAAAGCCTCTTTCGATACCATTGTCGCCAG
TGGCTGGCGTGGGGCGCTGCCGCACGGCAAAGCCAGCGACAAGATTGTTGCAGCGGGCGAGTTTGTCACTCTTGATTTTG
GTGCGCTGTATCAGGGCTACTGCTCTGATATGACGCGTACCTTGCTGGTGAATGGCGAAGGGGTGAGCGCCGAATCTCAC
CCACTGTTTGATGTGTATAACATTGTCCTGCAGGCACAGCTCGCGGCAATCTCCGCGATTCGCCCCGGCGTGCGCTGCCA
GCAGGTTGACGACGCCGCGCGCCGGGTCATTACAGAAGCCGGTTATGGTGACTATTTTGGTCATAACACCGGTCATGCTA
TCGGCATTGAAGTCCATGAAGATCCGCGTTTTTCACCGCGGGACACCACGACGCTACAGCCAGGGATGTTACTGACCGTG
GAGCCGGGGATTTATTTGCCAGGGCGAGGGGGCGTGCGCATCGAAGATGTCGTGCTGGTTACCCCGCAAGGCGCGGAAGT
GCTCTACGCCATGCCAAAAACAGTGTTGCTCACGGGAGAGGCATAA

Upstream 100 bases:

>100_bases
TGGGGGCAGTCATAACTGCGCTGATGGTGGTGTTCCTGCGTCTGATGATGTTCCGTAAAGGCAAATTGTTAATCGATAGC
CTGTAAGAAGGACAATCCTG

Downstream 100 bases:

>100_bases
TGGATTTATCGCTATTAAAAGCGTTGAGCGAGGCAGATGCGATCGCCTCCTCGGAACAGGAAGTGCGGCAGATCCTGCTG
GATGAAGCGGATCGACTGCA

Product: aminopeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDATNTLTTI
VNQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
CEIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFDVYNIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTV
EPGIYLPGRGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Sequences:

>Translated_361_residues
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDATNTLTTI
VNQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSE
CEIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
PLFDVYNIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTV
EPGIYLPGRGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA
>Mature_360_residues
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVEARTQGYQLHLLDATNTLTTIV
NQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSEC
EIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHP
LFDVYNIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHEDPRFSPRDTTTLQPGMLLTVE
PGIYLPGRGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGEA

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=254, Percent_Identity=31.1023622047244, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI260593665, Length=307, Percent_Identity=28.0130293159609, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI149589008, Length=307, Percent_Identity=28.0130293159609, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI264681563, Length=198, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI260593663, Length=242, Percent_Identity=29.7520661157025, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI93141226, Length=174, Percent_Identity=34.4827586206897, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI264681565, Length=195, Percent_Identity=31.7948717948718, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788728, Length=361, Percent_Identity=97.7839335180055, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI1789275, Length=254, Percent_Identity=29.9212598425197, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1786364, Length=251, Percent_Identity=23.9043824701195, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790282, Length=300, Percent_Identity=26, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=312, Percent_Identity=28.525641025641, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71989583, Length=256, Percent_Identity=26.5625, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509539, Length=169, Percent_Identity=33.1360946745562, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321118, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6320922, Length=240, Percent_Identity=24.1666666666667, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19920384, Length=260, Percent_Identity=27.6923076923077, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357079, Length=294, Percent_Identity=28.2312925170068, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137632, Length=172, Percent_Identity=33.7209302325581, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39558; Mature: 39427

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECEE
ARTQGYQLHLLDATNTLTTIVNQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSECEIAAELEWFMRQQGAEKAS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
FDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLFDVYNIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
DPRFSPRDTTTLQPGMLLTVEPGIYLPGRGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C
>Mature Secondary Structure 
TLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHILVDSRYYADVE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCEEEEECCEEECEE
ARTQGYQLHLLDATNTLTTIVNQIIADEQLQTLGFEGQQVSWETAHRWQSELNAKLVSAT
CCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEECCC
PDVLRQIKTPEEVEKIRLACGIADRGAEHIRRFIQAGMSECEIAAELEWFMRQQGAEKAS
HHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHH
FDTIVASGWRGALPHGKASDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESH
HHHHHCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLFDVYNIVLQAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHE
CHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
DPRFSPRDTTTLQPGMLLTVEPGIYLPGRGGVRIEDVVLVTPQGAEVLYAMPKTVLLTGE
CCCCCCCCCCEECCCEEEEECCCEEECCCCCCEEEEEEEECCCCCEEEEECCCEEEEECC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]