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The map label for this gene is pbpC [H]

Identifier: 218548044

GI number: 218548044

Start: 655462

End: 657774

Strand: Direct

Name: pbpC [H]

Synonym: EFER_0653

Alternate gene names: 218548044

Gene position: 655462-657774 (Clockwise)

Preceding gene: 218548043

Following gene: 218548045

Centisome position: 14.28

GC content: 52.62

Gene sequence:

>2313_bases
ATGCGTCGCCTGATAAGTAAACGCGGCTGCTGGATTTCGTTAGCAGCCGCGCCCATTCTCCTGATTCTTGTTGCGTGGGG
GGCTGATAAACTCTGGCCTCTTCCGCTACAGGAAGTTGCTCCTGCACGTGTTGTTGTTGCTCATGATGGTACGCCACTGT
GGCGTTTTGCCGATGCTGATGGAATCTGGCGTTATCCGGTCACCATTGACGATGTTTCGCCGCGTTACCTTGAAGCGTTG
ATCAACTATGAAGATCGTTGGTTCTGGAAACATCCCGGCGTTAACCCCTTCTCGGTGGTGCGTGCGGCCTGGCAAGATCT
TACGTCTGGCAGGGTGATCTCCGGTGGTAGCACACTTACCATGCAGGTTGCTCGTTTGCTTGATCCACACCCGAAAACTT
TTGGCGGGAAAATTCGCCAGCTCTGGCGTGCGTTTCAGCTGGAGTGGCACTTATCCAAACGTGAAATTCTGACGCTGTAC
CTTAACCGTGCTCCATTTGGCGGTACGTTACAGGGGATTGGTGCGGCAAGCTGGGCTTACCTGGGTAAGTCTCCGGCTAA
TTTAAGTTACTCTGAAGCTGCAATGCTGGCCGTTTTGCCACAGGCCCCCAGCCGCCTGCGTCCGGATCGTTGGCCAGAGC
GTGCTGAAGCTGCACGCAATAAAGTGCTTGAACGTATGGCAACACAAGGCGTGTGGTCTGTTAAGCAGGTGAACGAGTCG
CGCGAAGAGCCAGTCTGGTTGGCGCCGAGACAAATGCCACAACTGGCACCGCTGTTTTCGCGGATGATGTTGGGTAAAAG
CAAAAGCGACAAAATCGTAACCACGCTGGACGCAGGGTTACAACGACAGTTGGAAGAGTTGGCACAAAACTGGAAAAGTC
GCTTACCACCACGCAGTTCGTTGGCACTGATCGTTGTTGATCATACTGATATGAGTGTGCGTGGTTGGGTAGGATCTGTT
GATCTTAATGATGATTCCCGTTTTGGGCATGTCGATATGGTTAACGCGATCCGATCACCAGGATCGGTGCTTAAACCGTT
TGTTTATGCTTTGGCATTGGATGAAGGATTAATCCATCCGTCATCGTTGTTGCAGGATGTTCCCCGGCGTACAGGTGATT
ATCGCCCTGGCAATTTTGACAGTGGTTTTCATGGCCCGATCAGCATGAGCGAAGCCCTGGTTCGCTCACTGAACTTACCT
GCAGTGCAAGTTCTGGAGGCCTACGGCCCAAAAAGATTTGCGGCGAAATTGCGTAATGTTGGCTTGCCTCTGTATTTACC
TGCGGGAGCGGCGCCAAATCTTTCGTTAATTCTCGGCGGAGCTGGCGCTCGTCTGGATGAGATGGCGGCAGCCTATAGCG
CTTTTGCCCGCCACGGCAAAGCAGGTAAATTACGTTTACAGCCTGACGCTCCCTTAATTGAGCGACCATTAATGTCACCA
GGTGCGGCGTGGATAATCCGCCGCATCATGGCTGATGAAGCACAACCATTGCCGGACAGTTCCCTGCCGCGTATTGCGCC
TCTGGCATGGAAGACGGGCACCAGCTACGGTTACCGCGATGCATGGGCTATTGGCGTTAACGCTCGTTACGTAATCGGTA
TCTGGACAGGCAGACCGGACGGCACGCCCGTTGTCGGTCAGTTTGGCTTTGCCAGCGCAGTTCCTCTACTTAATCAGGTC
AATAACATCCTGATGTCGCGTAGTATAAATCTACCAGAAGATCCACGGCCGAAGTCTGTCAGTCGCGGTGTCATCTGCTG
GCCTGGTGGGCAATCATTGCCAGAAGGTGACAGTAATTGCCGCCGTCGTCTTGCCACCTGGTTGCTCGAAGGTAGCCAGC
CACCAACATTACTTTTACCGGAGCAGGAAGGAATAAGTGGGATTCGTTTCCCCATCTGGCTTGATGAGCAAGGTAAACGT
GTTGCTGCTGATTGTCCTCAGGCTCGACAAGAAATGATTAATGTCTGGCCGTTACCGCTGGAACCCTGGCTACCTGCTGC
TGAACGACGAGTTGCACGCTTACCTGGAGCATCAACAAATTGCCCGCCCTATGGTCGCGATGCTCAGTTACCTTTGCAGT
TGATTGGTGTGCGTGATGGGGTAATTATCAAACGTTTGCCAGGAGCCAACGATGCATCATTACCAGTACAATCAAGCGGA
GGAACAGGCGAACGCTGGTGGTTTCTTAATGGTGAACCGTTAGCTGAACGTGGTCATAGCTTAACGTTGCGACTTCGCGA
GAAGGGTGAATATCAATTACTGGTAATGGACGAAATGGGGCAGGTGGCGACAGTGAGATTTGTCATGCAGTAG

Upstream 100 bases:

>100_bases
GGGAACCTATCTGGTACCGCAACCAATGGTTGAATCAATGTACGCGCCTCAGTGGCGGGCAAGTGGCGCGTCAGAGGGAT
TCATGGTTGTCAGACCGTAA

Downstream 100 bases:

>100_bases
TCTGTTTTGCTCATATTTGTTGCTTAAACTCGTTTTATTTTAAAAAAATGTTACCTCTATCAATAGTCAACAGCGCAGAT
GCTCTTTATAATCCGCGCCA

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 770; Mature: 770

Protein sequence:

>770_residues
MRRLISKRGCWISLAAAPILLILVAWGADKLWPLPLQEVAPARVVVAHDGTPLWRFADADGIWRYPVTIDDVSPRYLEAL
INYEDRWFWKHPGVNPFSVVRAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRAFQLEWHLSKREILTLY
LNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMATQGVWSVKQVNES
REEPVWLAPRQMPQLAPLFSRMMLGKSKSDKIVTTLDAGLQRQLEELAQNWKSRLPPRSSLALIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVNAIRSPGSVLKPFVYALALDEGLIHPSSLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAGKLRLQPDAPLIERPLMSP
GAAWIIRRIMADEAQPLPDSSLPRIAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNILMSRSINLPEDPRPKSVSRGVICWPGGQSLPEGDSNCRRRLATWLLEGSQPPTLLLPEQEGISGIRFPIWLDEQGKR
VAADCPQARQEMINVWPLPLEPWLPAAERRVARLPGASTNCPPYGRDAQLPLQLIGVRDGVIIKRLPGANDASLPVQSSG
GTGERWWFLNGEPLAERGHSLTLRLREKGEYQLLVMDEMGQVATVRFVMQ

Sequences:

>Translated_770_residues
MRRLISKRGCWISLAAAPILLILVAWGADKLWPLPLQEVAPARVVVAHDGTPLWRFADADGIWRYPVTIDDVSPRYLEAL
INYEDRWFWKHPGVNPFSVVRAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRAFQLEWHLSKREILTLY
LNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMATQGVWSVKQVNES
REEPVWLAPRQMPQLAPLFSRMMLGKSKSDKIVTTLDAGLQRQLEELAQNWKSRLPPRSSLALIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVNAIRSPGSVLKPFVYALALDEGLIHPSSLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAGKLRLQPDAPLIERPLMSP
GAAWIIRRIMADEAQPLPDSSLPRIAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNILMSRSINLPEDPRPKSVSRGVICWPGGQSLPEGDSNCRRRLATWLLEGSQPPTLLLPEQEGISGIRFPIWLDEQGKR
VAADCPQARQEMINVWPLPLEPWLPAAERRVARLPGASTNCPPYGRDAQLPLQLIGVRDGVIIKRLPGANDASLPVQSSG
GTGERWWFLNGEPLAERGHSLTLRLREKGEYQLLVMDEMGQVATVRFVMQ
>Mature_770_residues
MRRLISKRGCWISLAAAPILLILVAWGADKLWPLPLQEVAPARVVVAHDGTPLWRFADADGIWRYPVTIDDVSPRYLEAL
INYEDRWFWKHPGVNPFSVVRAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRAFQLEWHLSKREILTLY
LNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMATQGVWSVKQVNES
REEPVWLAPRQMPQLAPLFSRMMLGKSKSDKIVTTLDAGLQRQLEELAQNWKSRLPPRSSLALIVVDHTDMSVRGWVGSV
DLNDDSRFGHVDMVNAIRSPGSVLKPFVYALALDEGLIHPSSLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLP
AVQVLEAYGPKRFAAKLRNVGLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAGKLRLQPDAPLIERPLMSP
GAAWIIRRIMADEAQPLPDSSLPRIAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQV
NNILMSRSINLPEDPRPKSVSRGVICWPGGQSLPEGDSNCRRRLATWLLEGSQPPTLLLPEQEGISGIRFPIWLDEQGKR
VAADCPQARQEMINVWPLPLEPWLPAAERRVARLPGASTNCPPYGRDAQLPLQLIGVRDGVIIKRLPGANDASLPVQSSG
GTGERWWFLNGEPLAERGHSLTLRLREKGEYQLLVMDEMGQVATVRFVMQ

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=770, Percent_Identity=91.038961038961, Blast_Score=1432, Evalue=0.0,
Organism=Escherichia coli, GI87082258, Length=242, Percent_Identity=36.3636363636364, Blast_Score=136, Evalue=6e-33,
Organism=Escherichia coli, GI1786343, Length=569, Percent_Identity=26.5377855887522, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789601, Length=196, Percent_Identity=31.1224489795918, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 85126; Mature: 85126

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRLISKRGCWISLAAAPILLILVAWGADKLWPLPLQEVAPARVVVAHDGTPLWRFADAD
CCCCHHHCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCCCEEEEECCC
GIWRYPVTIDDVSPRYLEALINYEDRWFWKHPGVNPFSVVRAAWQDLTSGRVISGGSTLT
CEEECCEEECCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEECCCCHHH
MQVARLLDPHPKTFGGKIRQLWRAFQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAY
HHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEEECCCCCCCCCCCCCHHHHH
LGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMATQGVWSVKQVNES
HCCCCCCCCHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
REEPVWLAPRQMPQLAPLFSRMMLGKSKSDKIVTTLDAGLQRQLEELAQNWKSRLPPRSS
HCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LALIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVNAIRSPGSVLKPFVYALALDEGLIHP
EEEEEEECCCCEEECEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
SSLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNV
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC
GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAGKLRLQPDAPLIERPLMSP
CCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCC
GAAWIIRRIMADEAQPLPDSSLPRIAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPD
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC
GTPVVGQFGFASAVPLLNQVNNILMSRSINLPEDPRPKSVSRGVICWPGGQSLPEGDSNC
CCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHH
RRRLATWLLEGSQPPTLLLPEQEGISGIRFPIWLDEQGKRVAADCPQARQEMINVWPLPL
HHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEHHCCHHHHHHHHEECCCCC
EPWLPAAERRVARLPGASTNCPPYGRDAQLPLQLIGVRDGVIIKRLPGANDASLPVQSSG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCEEECCC
GTGERWWFLNGEPLAERGHSLTLRLREKGEYQLLVMDEMGQVATVRFVMQ
CCCCEEEEECCCHHHHCCCEEEEEEECCCCEEEEEECCCCCEEEEEEEEC
>Mature Secondary Structure
MRRLISKRGCWISLAAAPILLILVAWGADKLWPLPLQEVAPARVVVAHDGTPLWRFADAD
CCCCHHHCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCCCEEEEECCC
GIWRYPVTIDDVSPRYLEALINYEDRWFWKHPGVNPFSVVRAAWQDLTSGRVISGGSTLT
CEEECCEEECCCCHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCCCEEECCCCHHH
MQVARLLDPHPKTFGGKIRQLWRAFQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAY
HHHHHHHCCCCCCCCHHHHHHHHHHHHHEECCCCEEEEEEEECCCCCCCCCCCCCHHHHH
LGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMATQGVWSVKQVNES
HCCCCCCCCHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH
REEPVWLAPRQMPQLAPLFSRMMLGKSKSDKIVTTLDAGLQRQLEELAQNWKSRLPPRSS
HCCCEEECCCCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LALIVVDHTDMSVRGWVGSVDLNDDSRFGHVDMVNAIRSPGSVLKPFVYALALDEGLIHP
EEEEEEECCCCEEECEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
SSLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNV
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHC
GLPLYLPAGAAPNLSLILGGAGARLDEMAAAYSAFARHGKAGKLRLQPDAPLIERPLMSP
CCCEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCC
GAAWIIRRIMADEAQPLPDSSLPRIAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPD
CHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCCEEEEEEEECCCC
GTPVVGQFGFASAVPLLNQVNNILMSRSINLPEDPRPKSVSRGVICWPGGQSLPEGDSNC
CCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHH
RRRLATWLLEGSQPPTLLLPEQEGISGIRFPIWLDEQGKRVAADCPQARQEMINVWPLPL
HHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEECCCCCEEHHCCHHHHHHHHEECCCCC
EPWLPAAERRVARLPGASTNCPPYGRDAQLPLQLIGVRDGVIIKRLPGANDASLPVQSSG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCEEECCC
GTGERWWFLNGEPLAERGHSLTLRLREKGEYQLLVMDEMGQVATVRFVMQ
CCCCEEEEECCCHHHHCCCEEEEEEECCCCEEEEEECCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]