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The map label for this gene is hemH [H]

Identifier: 218547922

GI number: 218547922

Start: 525537

End: 526499

Strand: Direct

Name: hemH [H]

Synonym: EFER_0525

Alternate gene names: 218547922

Gene position: 525537-526499 (Clockwise)

Preceding gene: 218547921

Following gene: 218547924

Centisome position: 11.45

GC content: 53.58

Gene sequence:

>963_bases
ATGCGTCAAACTAAAACCGGTATTCTGCTGGCAAACCTGGGTACACCCGATGCCCCCACTCCTGAAGCGGTAAAACGCTA
CCTGAAACAATTTTTAAGCGACAGACGCGTGGTTGATACCTCACGGCTGTTGTGGTGGCCGTTGCTGCGCGGCGTAATTT
TGCCGCTGCGCTCGCCGCGTGTGGCGAAGTTGTATGCCTCTGTCTGGATGGAAGGTGGCTCGCCGCTGATGGTTTACAGC
CGTCAGCAACAGCAGGCGCTGGCACAACGCTTACCGGATATGCCCGTGGCGCTGGGAATGAGTTATGGCTCGCCATCACT
GGAAAGCGCCGTAGATGAACTACTGGCAGAACATGTAGATCATATCGTGGTGCTGCCGCTTTATCCGCAATACTCCTGTT
CAACGGTCGGTGCGGTATGGGATGAGCTGGCACGCATTCTGGCGCGCAAACGTAGCATTCCGGGGATATCGTTTATTCGT
GATTACGCCGATAACCACGATTACATTAATGCACTGGCGAACAGCGTACGTGCCTCTTTCGCTAAACATGGCGAACCGGA
TCTACTGCTGCTCTCTTATCATGGTATTCCCCAGCGTTATGCCGATGAAGGCGATGATTACCCGCAACGTTGTCGCACAA
CGACTCGCGAACTGGCTTCCGCGCTGGGGATGGCACCGGAAAAAGTGATGATGACCTATCAGTCACGCTTTGGTCGGGAA
CCCTGGTTGATGCCTTATACCGACGAAACACTGAAAATGCTCGGAGAAAAAGGTGTCGGTCATATCCAGGTGATGTGTCC
GGGCTTTGCGGCGGATTGTCTGGAGACGCTGGAAGAGATTGCCGAGCAAAACCGTGAAGTCTTCCTCGGTGCGGGCGGGA
AAAAATACGAATATATTCCGGCGCTTAATGCCGCACCGGAACATATCGAAATGATGGCTAGTCTTGTTGCAGCGTATCGC
TAA

Upstream 100 bases:

>100_bases
TCTGCTCATTCTCCTCAGGCAATACCTCTTGCAGCAATTAGTTCTTCTTCTTCACTTTTCCGCTACAATTATCAACAAGT
TGAATCGATAAGAGGCGGTA

Downstream 100 bases:

>100_bases
AGAACTGAGCGCCGTCGCGAAGAGCATCGTCGGCGGTTTTCATCATCCGTGAATAATGCAAAAAGGCGTGCAGCGTGCCT
GGGTAGAGTTTGAACTTACA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNAAPEHIEMMASLVAAYR

Sequences:

>Translated_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNAAPEHIEMMASLVAAYR
>Mature_320_residues
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYS
RQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIR
DYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGRE
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNAAPEHIEMMASLVAAYR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=334, Percent_Identity=26.3473053892216, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=26.4264264264264, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786681, Length=320, Percent_Identity=98.4375, Blast_Score=654, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=27.2189349112426, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17864156, Length=336, Percent_Identity=25.5952380952381, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651774, Length=269, Percent_Identity=26.7657992565056, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35846; Mature: 35846

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEGGSPLMVYSRQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEHCCCCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEECC
ALNAAPEHIEMMASLVAAYR
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPR
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCH
VAKLYASVWMEGGSPLMVYSRQQQQALAQRLPDMPVALGMSYGSPSLESAVDELLAEHVD
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCEEHCCCCCCCHHHHHHHHHHHHHCC
HIVVLPLYPQYSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
AKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTYQSRFGRE
HHCCCCCEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
PWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIP
CCCCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEECC
ALNAAPEHIEMMASLVAAYR
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA