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The map label for this gene is tyrA [H]

Identifier: 218547878

GI number: 218547878

Start: 472920

End: 474041

Strand: Direct

Name: tyrA [H]

Synonym: EFER_0469

Alternate gene names: 218547878

Gene position: 472920-474041 (Clockwise)

Preceding gene: 218547877

Following gene: 218547883

Centisome position: 10.31

GC content: 51.78

Gene sequence:

>1122_bases
ATGGTTGCTGAATTGACCGCATTACGCGATCAAATTGATGAAGTCGATAAAGCGCTGCTGAATTTATTAGCGAAGCGTCT
GGAACTGGTTGCTGAAGTGGGCGAGGTGAAAAGCCGCTTTGGACTGCCTATTTATGTTCCGGAGCGCGAGGCATCTATGC
TGGCCTCGCGTCGTGCAGAGGCGGAAGCTCTGGGTGTACCGCCAGATCTGATTGAGGATGTTTTGCGTCGGGTGATGCGT
GAATCTTACTCCAGTGAAAACGACAAAGGATTTAAAACACTTTGTCCTGCGTTACGCCCGGTAGTTATCGTTGGTGGTGG
CGGTCAGATGGGACGCCTGTTCGAGAAGATGCTGACACTCTCGGGTTATCAGGTGCGGATTCTGGAGCAACATGACTGGG
ATCGAGCGGCTGATATTGTTGCCGATGCCGGAATGGTGATTGTTAGTGTGCCCATCCACGTTACTGAACAAGTTATTGGC
AAATTACCGACTTTACCGAAAGATTGTATTCTGGTCGATCTGGCATCAGTGAAAAATGGACCATTACAGGCCATGCTGGC
GGCGCATGATGGTCCGGTGCTGGGGCTACACCCGATGTTCGGTCCGGACAGCGGTAGCCTGGCAAAGCAAGTTGTGGTCT
GGTGTGATGGACGTAAGCCGGAAGCATACCAATGGTTTCTGGAGCAAATTCAGGTCTGGGGCGCTCGGCTGCATCGTATT
AGCGCTGTCGAGCACGATCAGAATATGGCGTTTATTCAGGCTCTGCGCCACTTTGCTACTTTTGCTTATGGGCTGCACCT
GGCAGAAGAAAATGTTCAGCTTGAGCAACTTCTGGCGCTTTCTTCGCCGATTTACCGCCTTGAGCTGGCGATGGTTGGGC
GACTGTTTGCCCAGGATCCGCAACTGTATGCCGACATTATTATGTCGTCAGAGCGTAATCTGGCGTTAATCAAACGTTAC
TATAAGCGTTTCGGCGAGGCGATTGAGTTGCTGGAGCAGGGCGATAAGCAGGCGTTTATTGACAGTTTCCGCAAGGTGGA
GCACTGGTTCGGCGATTACGCACAGCGTTTTCAGAGTGAAAGCCGCGTGTTATTGCGTCAGGCGAATGACAGTCGCCAGT
AA

Upstream 100 bases:

>100_bases
GATGCCTGCATTAGCTGGGAAATGACCGATGCCTTGCTGCGTGAAATTCATCAGGATCTGAACGGGCAGCTGACGGCTCG
CGTGGCTTAAGAGGTTTATT

Downstream 100 bases:

>100_bases
TAATCCAGTGCCGGGTGGCGTGTTTCACCCGGCACGATTTCATTATGCCGGATCGACTGGTACCACATTCTCGCTTGGGT
AACAGCCCAGGACTTTCATC

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAEAEALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPALRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIG
KLPTLPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVLLRQANDSRQ

Sequences:

>Translated_373_residues
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAEAEALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPALRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIG
KLPTLPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVLLRQANDSRQ
>Mature_373_residues
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAEAEALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLCPALRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIG
KLPTLPKDCILVDLASVKNGPLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSERNLALIKRY
YKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRVLLRQANDSRQ

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=373, Percent_Identity=98.9276139410188, Blast_Score=754, Evalue=0.0,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 41976; Mature: 41976

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AEALGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPALRPVVIVGGGGQMGRLFEKMLTL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHC
SGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIGKLPTLPKDCILVDLASVKNG
CCCEEEEECCCCCHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCHHHEEEHHHCCCC
PLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
CHHHHHHHCCCCEEEECCCCCCCCCHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSERNLALIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRVLLRQANDSRQ
HHHHHHHCCCCCC
>Mature Secondary Structure
MVAELTALRDQIDEVDKALLNLLAKRLELVAEVGEVKSRFGLPIYVPEREASMLASRRAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AEALGVPPDLIEDVLRRVMRESYSSENDKGFKTLCPALRPVVIVGGGGQMGRLFEKMLTL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHHC
SGYQVRILEQHDWDRAADIVADAGMVIVSVPIHVTEQVIGKLPTLPKDCILVDLASVKNG
CCCEEEEECCCCCHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCHHHEEEHHHCCCC
PLQAMLAAHDGPVLGLHPMFGPDSGSLAKQVVVWCDGRKPEAYQWFLEQIQVWGARLHRI
CHHHHHHHCCCCEEEECCCCCCCCCHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVQLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSERNLALIKRYYKRFGEAIELLEQGDKQAFIDSFRKVEHWFGDYAQRFQSE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRVLLRQANDSRQ
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]