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The map label for this gene is gabP [H]

Identifier: 218547822

GI number: 218547822

Start: 418664

End: 420064

Strand: Reverse

Name: gabP [H]

Synonym: EFER_0409

Alternate gene names: 218547822

Gene position: 420064-418664 (Counterclockwise)

Preceding gene: 218547823

Following gene: 218547821

Centisome position: 9.15

GC content: 50.68

Gene sequence:

>1401_bases
ATGGGGCAATCATCGCAACCACATGAGTTAGGCGGCGGGCTGAAATCACGCCACGTCACCATGTTGTCTATTGCCGGTGT
TATCGGCGCAAGTCTGTTTGTCGGTTCCAGCGTCGCCATCGCCGAAGCGGGTCCAGCGGTATTACTGGCCTATCTGTTCG
CCGGATTACTGGTGGTTATGATTATGCGGATGTTGGCGGAAATGGCGGTTGCCACGCCCGACACGGGTTCGTTTTCCACC
TATGCCGATAAAGCTATTGGCCGTTGGGCGGGTTATACCATCGGCTGGCTGTACTGGTGGTTTTGGGTACTGGTTATCCC
GCTGGAAGCCAACATCGCCGCCATGATCCTGCACTCGTGGGTTCCAGGCATTCCCATCTGGTTATTTTCCCTCGTCATTA
CCCTCGCCTTAACTGGCAGTAATTTATTAAGCGTTAAAAACTACGGCGAATTTGAGTTCTGGCTGGCGCTGTGCAAAGTC
ATTGCCATTCTGGCCTTTATTTTCCTTGGTGCAGTCGCAATTAGCGGTTTTTATCCTTATGCCGACGTAAGCGGTATTTC
AAGATTATGGGATAGCGGCGGCTTTATGCCCAACGGCTTCGGCGCAGTATTAAGCGCGATGCTGATCACCATGTTCTCGT
TTATGGGCGCAGAAATTGTCACCATTGCCGCCGCGGAATCCGACACGCCGGAAAAACATATTGTCCGCGCCACCAACTCG
GTTATCTGGCGTATTTCTATCTTCTATTTGTGCTCTATTTTTGTCGTCGTGGCATTAATACCGTGGAATATGCCGGGGCT
GAAAGCCGTTGGATCTTATCGCTCGGTTCTGGAATTGCTCAATATTCCCCATGCGAAATTAATCATGGACTGCGTGATAT
TACTTTCCGTAACCAGTTGCCTGAACTCGGCGCTGTATACCGCTTCCAGAATGCTCTACTCCTTAAGCCGTCGCGGTGAT
GCTCCCGCGGTAATGGGTAAAATCAACCGCAGTAAAACCCCGTATGTGGCGGTATTACTCTCCACCGGCGCGGCATTTTT
AACGGTGGTGGTGAATTATTACGCGCCTGCGAAAGTGTTTAAATTTCTGATCGACAGCTCCGGCGCTATCGCCCTGCTGG
TTTATTTAGTCATCGCCGTTTCACAATTGCGGATGCGCAAAATTCTGCGAGCAGAAGGAAGCGAAATTCGCCTGCGGATG
TGGCTTTATCCGTGGCTCACCTGGCTGGTAATCGGCTTTATTACCTTTGTGTTGGTAGTGATGCTATTCCGCCCGGCGCA
ACAGTTAGAAGTGATCTCCACCGGTTTATTAGCGATAGGGATAATCTGTACCGTGCCGATTATGGCGCGCTGGAAAAAAC
TGGTATTGTGGCAAAAAACACCCGTTCATAATACGCGCTAA

Upstream 100 bases:

>100_bases
CGCTCTCCGGCAAAAAGAACCAATAACAATTAAACGCGTGACCCGACGCGGGAAATGTCGGGCCGCTCTCCCAAGTGTCA
CACTTTCGAGAGGATTCAGG

Downstream 100 bases:

>100_bases
TAATGATCAGGAGTCACACCATGACCATTACGTCTCTGGATGGCTATCGCTGGCTGAAGAACGATATTATTCGCGGTAAT
TTTCAACCGGATGAAAAATT

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Sequences:

>Translated_466_residues
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIFLGAVAISGFYPYADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRM
WLYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
>Mature_465_residues
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSWVPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIFLGAVAISGFYPYADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNSV
IWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDA
PAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMW
LYPWLTWLVIGFITFVLVVMLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=99.7854077253219, Blast_Score=928, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=435, Percent_Identity=35.8620689655172, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1786789, Length=431, Percent_Identity=36.6589327146172, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=35.6164383561644, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI48994972, Length=464, Percent_Identity=32.9741379310345, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1788480, Length=392, Percent_Identity=34.1836734693878, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081915, Length=408, Percent_Identity=33.3333333333333, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI1786602, Length=431, Percent_Identity=33.4106728538283, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=29.9776286353468, Blast_Score=225, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=23.3516483516484, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=30.4740406320542, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=29.5711060948081, Blast_Score=199, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.6127562642369, Blast_Score=186, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6324553, Length=389, Percent_Identity=31.8766066838046, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324990, Length=421, Percent_Identity=31.1163895486936, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324924, Length=464, Percent_Identity=28.8793103448276, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=410, Percent_Identity=30.7317073170732, Blast_Score=169, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6320717, Length=413, Percent_Identity=29.0556900726392, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6319824, Length=408, Percent_Identity=28.4313725490196, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=401, Percent_Identity=27.6807980049875, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=26.3636363636364, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321629, Length=400, Percent_Identity=27.5, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=28.4313725490196, Blast_Score=148, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=27.7227722772277, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322967, Length=406, Percent_Identity=26.6009852216749, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=405, Percent_Identity=29.8765432098765, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6319608, Length=437, Percent_Identity=26.3157894736842, Blast_Score=124, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=480, Percent_Identity=23.9583333333333, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667468, Length=406, Percent_Identity=23.3990147783251, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51067; Mature: 50936

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GQSSQPHELGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGRWAGYTIGWLYWWFWVLVIPLEANIAAMILHSW
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
VPGIPIWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIFLGAVAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ADVSGISRLWDSGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPEKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKAVGSYRSVLELLNIPHAKLIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAVMGKINRSKTPYVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAVSQLRMRKILRAEGSEIRLRMWLYPWLTWLVIGFITFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLAIGIICTVPIMARWKKLVLWQKTPVHNTR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]