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The map label for this gene is guaC [H]

Identifier: 218547560

GI number: 218547560

Start: 135299

End: 136342

Strand: Direct

Name: guaC [H]

Synonym: EFER_0125

Alternate gene names: 218547560

Gene position: 135299-136342 (Clockwise)

Preceding gene: 218547556

Following gene: 218547565

Centisome position: 2.95

GC content: 49.71

Gene sequence:

>1044_bases
ATGCGTATCGAAGAAGATCTGAAATTAGGTTTCAAAGACGTTCTCATCCGCCCTAAACGCTCCACTCTCAAAAGTCGCTC
CGATGTTGAACTGGAACGCCAATTCACCTTTAAACACTCAGGCCAAAGCTGGTCAGGTGTACCTATTATTGCCGCAAACA
TGGATACCGTTGGAACATTTTCCATGGCATCTGCACTGGCCTCTTTCGACATTTTGACTGCTGTTCATAAACATTATTCT
GTTGAAGAATGGCTGGCGTTTGTGAACAGCTCTTCTGTCGACGTGCTGAAACATGTCATGGTTTCCACCGGAACTTCTGA
CGCTGATTTCGAAAAAACCAAACAAATTTTGGCGCTTAATCCGGCATTAAACTTCGTTTGTATTGATGTAGCGAATGGCT
ACTCCGAACATTTCGTCCAGTTTGTGGCGAAAGCGCGTGAAGCATGGCCGACCAAAACCATTTGTGCAGGCAATGTGGTA
ACTGGCGAAATGTGCGAAGAGCTGATCCTGTCTGGCGCTGATATCGTTAAAGTCGGCATTGGTCCAGGCTCTGTTTGTAC
AACTCGCGTGAAAACGGGTGTCGGTTATCCGCAACTTTCTGCGGTAATCGAATGTGCCGATGCGGCACACGGTTTGGGCG
GTATGATTGTCAGCGATGGCGGTTGCACCACGCCGGGCGATGTCGCTAAAGCCTTTGGCGGCGGTGCCGATTTCGTGATG
CTGGGCGGTATGCTGGCGGGTCACGAAGAAAGTGGCGGACGTATTGTCGAAGAGAACGGCGAGAAATTTATGCTGTTCTA
CGGTATGAGCTCCGAGTCTGCCATGAAACGCCACGTTGGCGGCGTTGCGGAGTATCGCGCGGCAGAAGGTAAAACGGTTA
AGTTGCCGCTGCGTGGGCCGGTAGAAAATACCGCTCGCGATATTCTCGGTGGTCTGCGTTCCGCTTGCACTTATGTTGGT
GCTTCTCGTTTGAAAGAGTTGACCAAACGCACAACGTTTATTCGCGTTCAGGAACAAGAAAACCGTATTTTCAATAGCCT
GTAA

Upstream 100 bases:

>100_bases
AGAGAATTTCGCAGTCTTGCACGGTACTGATTAGTGCGTATGATAGCGTCACTGGAGTTGTGCTTTAACCCTTACTGCCA
TTAACCCCAGGAATCCGCAC

Downstream 100 bases:

>100_bases
CCACGCAACGCTGGCGTGCAAACTCACGCCAGCGTTATCCCATTCCACTCATTGCATCTCCAAGATGGAATATTGGTAAA
TACATTGCCACTACCAACGT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYS
VEEWLAFVNSSSVDVLKHVMVSTGTSDADFEKTKQILALNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVM
LGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRIFNSL

Sequences:

>Translated_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYS
VEEWLAFVNSSSVDVLKHVMVSTGTSDADFEKTKQILALNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVM
LGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRIFNSL
>Mature_347_residues
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYS
VEEWLAFVNSSSVDVLKHVMVSTGTSDADFEKTKQILALNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVV
TGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVM
LGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVG
ASRLKELTKRTTFIRVQEQENRIFNSL

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=344, Percent_Identity=68.6046511627907, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI50541952, Length=344, Percent_Identity=68.6046511627907, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI50541948, Length=344, Percent_Identity=68.6046511627907, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI50541956, Length=344, Percent_Identity=68.6046511627907, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI156104880, Length=344, Percent_Identity=65.9883720930232, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI66933016, Length=244, Percent_Identity=26.6393442622951, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI217035146, Length=244, Percent_Identity=27.8688524590164, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI217035148, Length=244, Percent_Identity=28.2786885245902, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI217035150, Length=244, Percent_Identity=27.8688524590164, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI217035152, Length=244, Percent_Identity=27.8688524590164, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI34328928, Length=244, Percent_Identity=27.8688524590164, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI34328930, Length=244, Percent_Identity=27.8688524590164, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI156616279, Length=244, Percent_Identity=27.8688524590164, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786293, Length=347, Percent_Identity=98.2708933717579, Blast_Score=705, Evalue=0.0,
Organism=Escherichia coli, GI1788855, Length=221, Percent_Identity=36.6515837104072, Blast_Score=125, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17560440, Length=343, Percent_Identity=65.597667638484, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI71994385, Length=174, Percent_Identity=35.0574712643678, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71994389, Length=168, Percent_Identity=35.1190476190476, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322012, Length=237, Percent_Identity=31.2236286919831, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323464, Length=235, Percent_Identity=31.063829787234, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323585, Length=235, Percent_Identity=31.063829787234, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319352, Length=120, Percent_Identity=36.6666666666667, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24641071, Length=267, Percent_Identity=26.5917602996255, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24641073, Length=267, Percent_Identity=26.5917602996255, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28571163, Length=267, Percent_Identity=26.5917602996255, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005993
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 37285; Mature: 37285

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHCCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCHHH
SMASALASFDILTAVHKHYSVEEWLAFVNSSSVDVLKHVMVSTGTSDADFEKTKQILALN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHEEEEC
PALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGI
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGP
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCC
>Mature Secondary Structure
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTF
CCCCHHHHCCHHHHEECCCHHHHCCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCHHH
SMASALASFDILTAVHKHYSVEEWLAFVNSSSVDVLKHVMVSTGTSDADFEKTKQILALN
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHEEEEC
PALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGI
CCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECCCCEEHHHHHHHHHCCCCEEEEEC
GPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVM
CCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCCHHH
LGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGP
HCCCCCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHCCHHHHHCCCCCEEEEECCCC
VENTARDILGGLRSACTYVGASRLKELTKRTTFIRVQEQENRIFNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA