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The map label for this gene is murC [H]

Identifier: 218547548

GI number: 218547548

Start: 122734

End: 124209

Strand: Direct

Name: murC [H]

Synonym: EFER_0113

Alternate gene names: 218547548

Gene position: 122734-124209 (Clockwise)

Preceding gene: 218547547

Following gene: 218547549

Centisome position: 2.67

GC content: 52.17

Gene sequence:

>1476_bases
ATGAATACACAACAATTGGCAAAACTGCGTTACATCGTGCCCGAAATGCGTCGCGTTCGGCACATTCACTTTGTCGGCAT
CGGTGGTGCCGGTATGGGCGGTATTGCCGAAGTTCTGGCCAATGAAGGTTATCAGATCAGTGGTTCAGATTTAGCGCCAA
ACCCGGTCACTCAGCAGTTAACAAACCTGGGCGCGACGATTTACTTTAACCATCGCCCGGAAAATGTGCGTGATGCCAGC
GTGGTGGTCGTCTCCAGTGCTATTTCTGCCGATAACCCGGAAATTGTTGCTGCCCATGAAGCGCGTATTCCGGTGATCCG
TCGTGCTGAAATGCTGGCCGAATTAATGCGTTTTCGTCACGGTATCGCCATTGCCGGGACACATGGTAAAACCACCACCA
CCGCAATGGTGTCCAGCATTTATGCAGAAGCGGGCCTTGATCCGACATTTGTTAACGGTGGTCTGGTGAAGGCAGCAGGT
GTTCATGCACGTTTAGGTCATGGCCGTTACCTGATTGCTGAAGCGGATGAGAGTGACGCGTCTTTCCTCCATCTGCAACC
GATGGTGGCGATTGTCACCAATATCGAAGCCGACCATATGGATACTTATCAGGGCGACTTCGAGAATTTAAAACAAACCT
TTATTAATTTTCTGCACAACTTACCGTTTTACGGTCGTGCAGTAATGTGTGTTGACGATCCGGTGATCCGCGAATTGTTA
CCACGTGTGGGCCGTCAAATTACCACTTACGGTTTCAGTGAAGATGCTGACGTGCGTGTGGAAGATTACCAGCAGATTGG
TCCGCAGGGGCACTTTACGTTACTGCGTCAGGACAAAGAACCTTTGCGTGTAACACTCAATGCGCCTGGCCGTCATAACG
CGCTGAATGCCGCAGCTGCGGTTGCAGTTGCCACGGAAGAGGGGATTGAAGATGACGTTATTCTGCGTGCGCTGGAGAGC
TTCCAGGGAACCGGCCGTCGCTTCGATTTCCTCGGTGAGTTCCCGTTGAATCCAGTGAATGGTAAAAGCGGTACGGCAAT
GCTGGTCGATGATTACGGTCACCACCCGACCGAAGTGGACGCGACGATTAAAGCAGCACGTGCAGGCTGGCCGGAGAAAA
ATCTGGTGATGTTGTTCCAGCCGCATCGTTTTACCCGTACCCGCGATCTGTATGATGACTTCGCCAATGTTCTGACGCAG
GTTGATACCCTGCTGATGCTGGAAGTCTATCCGGCAGGCGAATCCCCGATTCCAGGCGCAGATAGCCGTTCGCTTTGCCG
CACAATTCGCGGTCGCGGTAAAATCGATCCAATACTGGTGTCTGATCCCGCTAAAGTTGCAGAGATGCTGGCGCCGGTCC
TTACCGGTAACGATCTCATCCTCGTACAAGGGGCCGGGAATATCGGCAAGATTGCGCGTTATTTAGCAGAAATCAAACTC
AAGCCGCAAACTTCTGAGGATGGACAGCATGACTGA

Upstream 100 bases:

>100_bases
CCACTGAGCGGGTTGCAAACGAAGTGAGCCGGGCTGCCCGGTCTTAATTGTAGTGATGCCTTTTGCATCGCATGGATTTC
AGAAGTTAATGGCGTAAAGA

Downstream 100 bases:

>100_bases
TAAAATTGCTGTTCTGCTGGGTGGCACTTCCGCAGAGCGGGAAGTTTCACTGAATTCAGGTGCGGCTGTGTTGGCGGGTC
TGCGTGAAGGCGGTGTAGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQQLAKLRYIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPLRVTLNAPGRHNALNAAAAVAVATEEGIEDDVILRALES
FQGTGRRFDFLGEFPLNPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPEKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGESPIPGADSRSLCRTIRGRGKIDPILVSDPAKVAEMLAPVLTGNDLILVQGAGNIGKIARYLAEIKL
KPQTSEDGQHD

Sequences:

>Translated_491_residues
MNTQQLAKLRYIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPLRVTLNAPGRHNALNAAAAVAVATEEGIEDDVILRALES
FQGTGRRFDFLGEFPLNPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPEKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGESPIPGADSRSLCRTIRGRGKIDPILVSDPAKVAEMLAPVLTGNDLILVQGAGNIGKIARYLAEIKL
KPQTSEDGQHD
>Mature_491_residues
MNTQQLAKLRYIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLTNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQITTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPLRVTLNAPGRHNALNAAAAVAVATEEGIEDDVILRALES
FQGTGRRFDFLGEFPLNPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPEKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGESPIPGADSRSLCRTIRGRGKIDPILVSDPAKVAEMLAPVLTGNDLILVQGAGNIGKIARYLAEIKL
KPQTSEDGQHD

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=491, Percent_Identity=96.7413441955193, Blast_Score=899, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=480, Percent_Identity=27.7083333333333, Blast_Score=142, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53652; Mature: 53652

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRYIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEEEECCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQITTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPLRVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIEDDVILRALESFQGTGRRFDFLGEFPLNPVNGKSGTAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPEKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGESPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCC
DSRSLCRTIRGRGKIDPILVSDPAKVAEMLAPVLTGNDLILVQGAGNIGKIARYLAEIKL
CHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEE
KPQTSEDGQHD
CCCCCCCCCCC
>Mature Secondary Structure
MNTQQLAKLRYIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
TNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEEEECCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQITTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPLRVTLNAPGRHNALNAAAA
HHHCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIEDDVILRALESFQGTGRRFDFLGEFPLNPVNGKSGTAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPEKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGESPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCC
DSRSLCRTIRGRGKIDPILVSDPAKVAEMLAPVLTGNDLILVQGAGNIGKIARYLAEIKL
CHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHEE
KPQTSEDGQHD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA