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The map label for this gene is kefC [H]

Identifier: 218547494

GI number: 218547494

Start: 56941

End: 58803

Strand: Direct

Name: kefC [H]

Synonym: EFER_0055

Alternate gene names: 218547494

Gene position: 56941-58803 (Clockwise)

Preceding gene: 218547493

Following gene: 218547495

Centisome position: 1.24

GC content: 55.66

Gene sequence:

>1863_bases
ATGGATAGCCATACGCTGATTCAGGCGCTGATTTATCTCGGTTCGGCGGCGCTGATTGTACCTATTGCGGTGCGTCTTGG
GCTTGGCTCGGTTCTTGGCTACCTGATCGCGGGCTGCATTATTGGCCCGTGGGGGCTGCGACTGGTGACCGATGCCGAAT
CTATCCTCCACTTTGCCGAGATTGGCGTGGTGCTGATGCTGTTTATCATCGGCCTCGAACTCGATCCACAAAGGCTGTGG
AAGTTGCGTGCGGCAGTGTTTGGTGGTGGTGCGCTGCAGATGGTGATTTGCGGTGGCCTGCTGGGGCTGTTCTGCATGTT
CCTTGGTCTGCGCTGGCAGGTAGCGGAACTGATCGGCATGACACTGGCGCTCTCATCAACGGCAATTGCCATGCAGGCGA
TGAATGAACGCAACCTGATGGTGACACAAATGGGCCGTAGCGCCTTTGCGGTGCTGCTGTTCCAGGATATCGCCGCGATC
CCGCTGGTAGCGATGATCCCGCTACTGGCGGCGAGCAGTGCCTCGACGACGATGGGCGCATTTGCTCTCTCGGCGTTAAA
AGTGGCGGGTGCACTGGTGCTGGTGGTACTGCTGGGGCGCTATGTCACGCGTCCGGCGCTGCGTTTTGTTGCCCGCTCTG
GCTTGCGGGAAGTGTTTAGTGCCGTGGCGTTATTCCTCGTGTTTGGCTTTGGTTTGCTGCTGGAAGAGGTCGGCTTGTCG
ATGGCGATGGGGGCGTTTCTGGCGGGCGTACTGCTGGCAAGCTCGGAATACCGTCATGCGCTGGAGAGCGATATCGAGCC
ATTTAAAGGTTTGCTGTTGGGGCTGTTTTTCATCGGTGTTGGCATGTCGATAGACTTTGGCACGCTGCTTGAAAATCCGT
TGCGCATTGTCATTTTGCTGCTCGGTTTCCTCATCATCAAAATCGCTATGCTGTGGCTGATTGCCCGACCGTTGCAGGTG
CCGAATAAACAGCGTCGCTGGTTTGCGGTGCTGTTAGGGCAGGGCAGTGAGTTTGCCTTTGTGGTATTTGGCGCGGCGCA
AATGGCGAATGTGCTGGAGCCGGAGTGGGCGAAGTCGCTGACCCTGGCGGTGGCGCTGTCGATGGCGGCAACGCCGATTC
TGCTGGTGATCCTCAATCGCCTTGAGCAATCTTCTACCGAACAAGCGCGTGAAGCCGATGAGATTGATGAAGAACAGCCG
CGGGTGATCATTGCTGGATTCGGTCGTTATGGACAGATTACCGGACGTTTACTGCTCTCCAGCGGGGTGAAAATGGTGGT
ACTCGATCACGATCCGGACCATATCGAAACGCTGCGAAAATTCGGCATGAAAGTGTTTTACGGCGATGCCACGCGGATGG
ATTTACTGGAATCTGCGGGAGCGGCGAAAGCGGAAGTGCTGATTAACGCCATCGACGATCCGCAAACCAACCTGCAACTG
ACGGAGATGGTGAAAGAACATTTCCCGCATTTGCAGATTATTGCCCGCGCCCGCGATGTTGACCACTACATTCGTTTGCG
TCAGGCAGGCGTTGAAAAGCCAGAGCGTGAAACCTTTGAAGGGGCACTGAAAACCGGGCGTCTGGCGCTGGAAAGTTTAG
GTCTGGGGCCGTATGAAGCGCGGGAGCGTGCAGATGTATTCCGCCGTTTTAATATTCAGATGGTGGAAGAGATGGCAGTA
GTTGAGAACGACACCAAAGCCCGCGCAGCGGTCTATAAACGCACCAGTGCGATGTTAAGTGAGATCATTACCGAAGACCG
CGAACATCTGTCATTAATTCAACGACATGGCTGGCAGGGCACCGAAGAAGGTAAACATACCGGCAACATGGCGGATGAAC
CGGAAACGAAACCCTCATCCTAA

Upstream 100 bases:

>100_bases
CCGTTTGCTATGCACTGCACCTTTATTTGTGACGACGAAACCCTCGAAGGGCAGGCGCGTCATTATAAGCAACGTCTGCT
GGAATGGCAGGAGGCATATC

Downstream 100 bases:

>100_bases
TAAAGAGTGACGTAAATCACACTTTACAGCTAACTGATTGTTTTTGTTTCATTGTAATGCGGCGAGTCCAGGAAGAGAGC
GTGGACTCGCCAGCAGAACG

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEQAREADEIDEEQP
RVIIAGFGRYGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAV
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS

Sequences:

>Translated_620_residues
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEQAREADEIDEEQP
RVIIAGFGRYGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAV
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
>Mature_620_residues
MDSHTLIQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMFLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLLENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEQAREADEIDEEQP
RVIIAGFGRYGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAV
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=383, Percent_Identity=25.5874673629243, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786232, Length=620, Percent_Identity=99.0322580645161, Blast_Score=1226, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=607, Percent_Identity=43.492586490939, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1786685, Length=519, Percent_Identity=28.9017341040462, Blast_Score=157, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67738; Mature: 67738

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA