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The map label for this gene is fixC [H]

Identifier: 218547490

GI number: 218547490

Start: 53350

End: 54636

Strand: Direct

Name: fixC [H]

Synonym: EFER_0051

Alternate gene names: 218547490

Gene position: 53350-54636 (Clockwise)

Preceding gene: 218547489

Following gene: 218547491

Centisome position: 1.16

GC content: 54.31

Gene sequence:

>1287_bases
ATGTCCGAAGATATCTTTGACGCCATCATCGTCGGTGCAGGGCTTGCCGGTTCGGTTGCCGCACTGGTGCTCGCCCGCGA
AGGTGCGCAAGTGTTAGTTATCGAGCGTGGCAATTCCGCAGGTGCCAAGAACGTCACCGGCGGGCGTCTCTATGCCCACA
GTCTGGAACACATTATTCCTGGTTTCGCCGAATCCGCCCCCGTAGAACGCCTGATCACCCATGAAAAACTCGCGTTTATG
ACGGAAAAGTCAGCGATGACTATGGACTACTGCAACGGTGACGAAACCTCACCATCACAGCGTTCTTACTCCGTTTTGCG
CAGTAAATTTGATGCCTGGCTGATGGAGCAGGCCGAAGAAGCGGGTGCGCAGTTAATTACCGGGATTCGTGTCGATAACC
TCGTACAGCGCGATGGCAAAGTCGTCGGTGTAGAAGCCGATGGCGATGTGATTGAAGCGAAAACGGTGATCCTTGCTGAC
GGAGTGAATTCCATCCTTGCCGAAAAGCTGGGGATGGCAAAACGCGTCAAACCGACGGATGTGGCGGTTGGCGTGAAGGA
ACTGATCGAGTTACCGAAGTCGGTTATCGAAGACCGTTTTCAGTTGCAGGGTAATCAGGGGGCGGCTTGCCTGTTTGCGG
GATCACCTACTGATGGCCTGATGGGCGGCGGCTTTCTTTATACCAATGAAAACACTCTGTCGCTGGGGTTGGTTTGTGGT
CTGCATCATCTGCATGACGCAAAAAAATCGGTGCCGCAAATGCTGGAAGATTTCAAACAGCATCCGGCCGTTGCACCGCT
GATCGCAGGCGGCAAGCTGGTGGAATATTCCGCTCACGTAGTGCCGGAAGCCGGCATCAACATGTTGCCGGAGCTGGTCG
GTGACGGCGTGTTGATTGCCGGTGATGCTGCCGGAATGTGTATGAACCTCGGTTTTACTATTCGCGGTATGGATCTGGCG
ATTGCCGCCGGGGAAGCTGCTGCAAAAACCGTGCTTTCAGCGATGAAAAGCGACGATTTCAGTAAGCAAAAACTAGCGGA
ATATCGTCAGTATCTGGAGAGTGGCCCACTGCGCGATATGCGCATGTACCAGAAACTACCGGCGTTCCTTGATAACCCAC
GCATGTTTAGCGGTTACCCGGAACTGGCGGTGGGCGTGGCGCGTGACCTGTTCACCATTGACGGCAGCGCGCCGGAACTG
ATGCGCAAGAAAATCCTCCGCCACGGCAAGAAAGTGGGCTTCATCAATCTGATCAAGGATGGCATGAAAGGAGTGACCGT
TTTATGA

Upstream 100 bases:

>100_bases
GCGACGCCGTGAAGATCCTTCCGGCACTGACCGCAGCTTTTGCGCGTTGATCCACTCTGGCAGGGCTGCATTTTGGCCCT
GCCGCTGACAGGGAGCTCTT

Downstream 100 bases:

>100_bases
CTTCTCCCGTAAATGTGGACGTCAAACTGGGCGTCAATAAATTCAATGTCGATGAAGAGCATCCGCACATTGTTGTAAAG
GCCGACGCGGATAAACAGGC

Product: oxidoreductase FixC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFAESAPVERLITHEKLAFM
TEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILAD
GVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
IAAGEAAAKTVLSAMKSDDFSKQKLAEYRQYLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPEL
MRKKILRHGKKVGFINLIKDGMKGVTVL

Sequences:

>Translated_428_residues
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFAESAPVERLITHEKLAFM
TEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILAD
GVNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLA
IAAGEAAAKTVLSAMKSDDFSKQKLAEYRQYLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPEL
MRKKILRHGKKVGFINLIKDGMKGVTVL
>Mature_427_residues
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIPGFAESAPVERLITHEKLAFMT
EKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEEAGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADG
VNSILAEKLGMAKRVKPTDVAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCGL
HHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIAGDAAGMCMNLGFTIRGMDLAI
AAGEAAAKTVLSAMKSDDFSKQKLAEYRQYLESGPLRDMRMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELM
RKKILRHGKKVGFINLIKDGMKGVTVL

Specific function: Could be part of an electron transfer system required for anaerobic carnitine reduction [H]

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF-QO/fixC family [H]

Homologues:

Organism=Homo sapiens, GI119703746, Length=392, Percent_Identity=26.530612244898, Blast_Score=112, Evalue=9e-25,
Organism=Escherichia coli, GI1786227, Length=428, Percent_Identity=99.5327102803738, Blast_Score=867, Evalue=0.0,
Organism=Escherichia coli, GI1787991, Length=429, Percent_Identity=61.3053613053613, Blast_Score=531, Evalue=1e-152,
Organism=Escherichia coli, GI87082155, Length=428, Percent_Identity=40.4205607476636, Blast_Score=317, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI25144720, Length=398, Percent_Identity=25.8793969849246, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6324932, Length=376, Percent_Identity=27.1276595744681, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24652256, Length=365, Percent_Identity=28.4931506849315, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: NA

Molecular weight: Translated: 45744; Mature: 45612

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIP
CCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFAESAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEE
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTD
HHHHHHHCCHHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHCCCCHH
VAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEHHHHHH
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
GDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQYLESGPLRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
RMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKD
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
GMKGVTVL
CCCCCCCC
>Mature Secondary Structure 
SEDIFDAIIVGAGLAGSVAALVLAREGAQVLVIERGNSAGAKNVTGGRLYAHSLEHIIP
CHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCC
GFAESAPVERLITHEKLAFMTEKSAMTMDYCNGDETSPSQRSYSVLRSKFDAWLMEQAEE
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AGAQLITGIRVDNLVQRDGKVVGVEADGDVIEAKTVILADGVNSILAEKLGMAKRVKPTD
HHHHHHHCCHHHHHHHCCCEEEEEECCCCEEEEEEEEEECCHHHHHHHHHCHHHCCCCHH
VAVGVKELIELPKSVIEDRFQLQGNQGAACLFAGSPTDGLMGGGFLYTNENTLSLGLVCG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCEEHHHHHH
LHHLHDAKKSVPQMLEDFKQHPAVAPLIAGGKLVEYSAHVVPEAGINMLPELVGDGVLIA
HHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCCCEEEE
GDAAGMCMNLGFTIRGMDLAIAAGEAAAKTVLSAMKSDDFSKQKLAEYRQYLESGPLRDM
CCCCCHHEECCEEEECCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHH
RMYQKLPAFLDNPRMFSGYPELAVGVARDLFTIDGSAPELMRKKILRHGKKVGFINLIKD
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCHHHHHHH
GMKGVTVL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]