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The map label for this gene is pyrD [H]

Identifier: 218235763

GI number: 218235763

Start: 3905009

End: 3905938

Strand: Reverse

Name: pyrD [H]

Synonym: BCB4264_A3982

Alternate gene names: 218235763

Gene position: 3905938-3905009 (Counterclockwise)

Preceding gene: 218232026

Following gene: 218234846

Centisome position: 72.08

GC content: 40.65

Gene sequence:

>930_bases
ATGAACAGATTGCAAGTTGAATTACCAGGATTATCATTAAAAAATCCAATTATACCGGCATCTGGATGCTTTGGGTTTGG
TCGTGAATATGCACAGTTTTACGATTTAAGTGTACTAGGATCAATCATGATTAAAGCGACGACAGAACAACCACGTTATG
GAAATCCAACGCCTCGTGTTGCTGAAACACCAGGCGGCATGCTAAATGCAATCGGACTTCAAAACCCGGGATTAGACAAA
GTAATGAATTCGGAATTACCATGGTTAGAACAATTTGACCTTCCAATTATTGCAAACGTTGCAGGCTCACAAGCTGAGGA
TTACGTAGCGGTTGCGAAGGAAATTTCTAAAGCGCCTAATGTCCATGCACTAGAATTAAACATTTCTTGTCCGAACGTAA
AAACAGGTGGTATCGCCTTTGGTACAAATCCTGAAATTGCTGCTGATTTAACGAAGCGAGTAAAAGAGGTTTCTGAAGTA
CCTGTATACGTGAAATTGTCACCGAACGTGGCAAACATAGTAGAAATTGCAAAAGCGATTGAAACTGCAGGTGCAGATGG
TTTAACGATGATTAATACATTGCTTGGTATGCGTCTAGATTTAAAAACAGCTAAACCAATTTTAGCAAACCGTACAGGCG
GATTATCAGGTCCTGCGATTAAGCCAGTAGCAATTCGCATGGTACATGAAGTAAGCCAAGCGGTTAACATTCCAATTATC
GGAATGGGTGGTATTGAAACAGCTGAAGATGTAATTGAATTCTTCTATGCTGGCGCAAGCGCAGTTGCAGTAGGTACAGC
GAACTTTATCGATCCGTTCGTATGTCCGACAATTATTGAAGAGTTACCAGCATTATTAGATGAATTAGGATTTGATCACA
TTTCGGAATGTCAAGGAAGGAGCTGGAAGCAAACATGTCACAGTCGTTAA

Upstream 100 bases:

>100_bases
GTTTCGCATGTGTATGCCACTTACAAGAAGATCCAAGTGGACATTCTTACAAGAAGGTGTGTAGCGACGGACCAGTATTT
CCAATCGGGGAGGTTGTACT

Downstream 100 bases:

>100_bases
TCGTTGCACTAGATTTTCCAGGGAAACAAGAAGTAGAACAATTCTTACACCACTTTGAAGGGGAAGAGTTATTTGTCAAA
GTAGGTATGGAGTTATTTTA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLDK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIETAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR

Sequences:

>Translated_309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLDK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIETAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR
>Mature_309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLDK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIETAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=344, Percent_Identity=30.2325581395349, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI45006951, Length=327, Percent_Identity=29.6636085626911, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI87082059, Length=218, Percent_Identity=31.1926605504587, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787177, Length=295, Percent_Identity=28.135593220339, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71984108, Length=210, Percent_Identity=34.2857142857143, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17509475, Length=322, Percent_Identity=28.5714285714286, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322633, Length=305, Percent_Identity=27.8688524590164, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24640763, Length=222, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18858217, Length=222, Percent_Identity=33.3333333333333, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI281361352, Length=324, Percent_Identity=29.320987654321, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17137316, Length=324, Percent_Identity=29.320987654321, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32963; Mature: 32963

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPGGMLNAIGLQNPGLDKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPN
CCCCCCCEEECCCCCCCHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
VHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAI
EEEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
ETAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
HHCCCCCHHHHHHHHCCEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
SWKQTCHSR
CHHHHHCCC
>Mature Secondary Structure
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPGGMLNAIGLQNPGLDKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPN
CCCCCCCEEECCCCCCCHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
VHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAI
EEEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
ETAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
HHCCCCCHHHHHHHHCCEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
SWKQTCHSR
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA