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The map label for this gene is hemH2 [H]

Identifier: 218235760

GI number: 218235760

Start: 1175213

End: 1176172

Strand: Direct

Name: hemH2 [H]

Synonym: BCB4264_A1208

Alternate gene names: 218235760

Gene position: 1175213-1176172 (Clockwise)

Preceding gene: 218234964

Following gene: 218230952

Centisome position: 21.69

GC content: 36.35

Gene sequence:

>960_bases
ATGACAAAGAAAAAAATAGGTTTACTCGTAATGGCGTATGGAACACCAGAATCATTAGACGATGTAGAGGCATATTATAC
ACATATCCGTCACGGGCGTACGCCATCAGAAGAAGCGCTTGAAGATTTAATTGGCCGCTATAAAGCGATTGGTGGAATTT
CGCCGCTTGCAAAAATTACGAAAGAACAGGCGCATAAATTAACAGATTCAATGAATAACATATTTACAGAGTATCAATTT
ACTTGTTACTTAGGTTTAAAACATATTGCACCATTTATAGAAGATGCGGTAGAAGAAATGAAGCGTGATGGGATCGAGCA
AGCGATTAGTATCGTATTAGCGCCACATTACTCTACATTTAGCACTAAAGCGTATAATGACCGTGCTATTCGTCTTTCAA
AAGAAATCGGTGGTCCTGTTATTGAACCAATTGAACAATGGTACGATGAACCGAAGTTTATTTCGTATTGGGCAAACCAA
ATAAAAGAGACGTTTACAGAAATTGATAATAAAGAGAAAGCAGTCGTAATTTTTTCAGCGCATAGTTTGCCAGAAAAAAT
TATTGCAACAGGAGACCCATATGTAGAACAACTAAAGCATACGGCAGATTTAATTGCAGAAGCTGCAAATATTCAAAACT
ATACAATCGGTTGGCAAAGTGCTGGGAATACTCCGGATCCGTGGATTGGTCCAGATGTGCAAGATTTAACGAAAGATTTA
TATGAAGAGCATGGGTACGAATCTTTCGTATATTGCCCAGTTGGTTTTGTAGCGGAGCATTTAGAAGTTTTATATGACAA
CGATTATGAATGTAAAGTTGTAACGGATGAATTAAATGCCAAATATTTCAGACCAAATATGCCGAATGCACAATCTGCAT
TTATCGACTGTTTGGCTGAAATTGTTTCCAAAAAAGTGAAGGAAATAGTTGACAAAGATTTAGTTTTGAATAATAATTAA

Upstream 100 bases:

>100_bases
AATTAGAATTATTATTTTGACGTATTTATTATTACTTGTTATAATTGGAAACGAATGTTCTGAAAAGTATTCTCATTTAT
AAAATTGAGGTGTTATATAT

Downstream 100 bases:

>100_bases
TTTATAATAATTTTAAATAAATAATTATTACTACGAAAGAAAGAGGAGGATCCCCCTAGATGAATCCAAATAATCGCTTA
ACAACAAACCAAGGTGCTCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 2; Protoheme ferro-lyase 2 [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MTKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRTPSEEALEDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNIFTEYQF
TCYLGLKHIAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSTKAYNDRAIRLSKEIGGPVIEPIEQWYDEPKFISYWANQ
IKETFTEIDNKEKAVVIFSAHSLPEKIIATGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDL
YEEHGYESFVYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAEIVSKKVKEIVDKDLVLNNN

Sequences:

>Translated_319_residues
MTKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRTPSEEALEDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNIFTEYQF
TCYLGLKHIAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSTKAYNDRAIRLSKEIGGPVIEPIEQWYDEPKFISYWANQ
IKETFTEIDNKEKAVVIFSAHSLPEKIIATGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDL
YEEHGYESFVYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAEIVSKKVKEIVDKDLVLNNN
>Mature_318_residues
TKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRTPSEEALEDLIGRYKAIGGISPLAKITKEQAHKLTDSMNNIFTEYQFT
CYLGLKHIAPFIEDAVEEMKRDGIEQAISIVLAPHYSTFSTKAYNDRAIRLSKEIGGPVIEPIEQWYDEPKFISYWANQI
KETFTEIDNKEKAVVIFSAHSLPEKIIATGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDLY
EEHGYESFVYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAEIVSKKVKEIVDKDLVLNNN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=343, Percent_Identity=28.8629737609329, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI60499021, Length=341, Percent_Identity=29.0322580645161, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786681, Length=184, Percent_Identity=26.6304347826087, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324750, Length=290, Percent_Identity=24.8275862068966, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=26.6666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24651774, Length=259, Percent_Identity=25.0965250965251, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45552018, Length=169, Percent_Identity=30.1775147928994, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36170; Mature: 36039

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRTPSEEALEDLIGRYKAIGGISPLAKIT
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNIFTEYQFTCYLGLKHIAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
STKAYNDRAIRLSKEIGGPVIEPIEQWYDEPKFISYWANQIKETFTEIDNKEKAVVIFSA
CCCCCCCHHEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HSLPEKIIATGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDL
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
YEEHGYESFVYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAE
HHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSKKVKEIVDKDLVLNNN
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKKKIGLLVMAYGTPESLDDVEAYYTHIRHGRTPSEEALEDLIGRYKAIGGISPLAKIT
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHH
KEQAHKLTDSMNNIFTEYQFTCYLGLKHIAPFIEDAVEEMKRDGIEQAISIVLAPHYSTF
HHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
STKAYNDRAIRLSKEIGGPVIEPIEQWYDEPKFISYWANQIKETFTEIDNKEKAVVIFSA
CCCCCCCHHEEEHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
HSLPEKIIATGDPYVEQLKHTADLIAEAANIQNYTIGWQSAGNTPDPWIGPDVQDLTKDL
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHH
YEEHGYESFVYCPVGFVAEHLEVLYDNDYECKVVTDELNAKYFRPNMPNAQSAFIDCLAE
HHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCHHHHHHHHHHH
IVSKKVKEIVDKDLVLNNN
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]