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The map label for this gene is npr [H]

Identifier: 218235151

GI number: 218235151

Start: 623763

End: 625463

Strand: Direct

Name: npr [H]

Synonym: BCB4264_A0638

Alternate gene names: 218235151

Gene position: 623763-625463 (Clockwise)

Preceding gene: 218231881

Following gene: 218233932

Centisome position: 11.51

GC content: 38.39

Gene sequence:

>1701_bases
ATGAAAAAGAAAAGTTTAGCGTTAGTGTTAGCGACAGGAATGGCAGTTACAACATTTGGAGGGACAGGCTCTGCATTTGC
GGATTCTAAAAATGTACTCTCTACGAAGAAGTACAATGAGACAGTACAGTCACCTGAGTTTATTTCTGGTGATCTAACTG
GAGCGACTGGTAAGAAAGCGGAATCTGTTGTGTTTGATTACTTAAATGCAGCAAAAGGTGATTACAAGCTAGGGGAAAAG
AGTGCGCAAGATTCTTTCAAAGTGAAACAAGTGAAGAAAGATGCTGTAACTGATTCAACAGTAGTACGTATGCAACAAGT
TTACGAAGGAGTGCCTGTATGGGGTTCTACTCAAGTGGCTCACGTAAGTAAAGACGGTTCTTTAAAAGTATTGTCTGGAA
CAGTTGCACCTGATTTAGACAAAAAGGAAAAGTTGAAAAATAAAAATAAGATTGAAGGCGCAAAAGCAATTGAAATCGCG
CAGCAAGATTTAGGGGTAACACCGAAATATGAAGTAGAACCAAAAGCGGACTTATATGTATATCAAAACGGTGAGGAAAC
AACATATGCATATGTTGTAAATCTAAACTTCTTAGATCCAAGCCCAGGAAACTACTACTATTTCATTGAGGCAGACAGCG
GTAAAGTATTAAATAAGTTTAATACAATTGATCATGTGACGAATGATGATAAGTCACCAGTTAAGCAAGAGGCTCCTAAA
CAGGATGCGAAAGCTGTTGTAAAGCCTGTAACAGGAACGAATAAAGTAGGAACTGGTAAAGGTGTATTAGGAGATACGAA
GTCGCTTAATACAACGTTATCTGGATCATCTTACTACTTACAAGATAATACACGCGGGGCAACGATTTTCACATATGATG
CGAAAAACCGTTCAACATTACCAGGAACATTATGGGCAGATGCAGATAATGTTTTCAATGCAGCGTATGATGCAGCAGCA
GTAGATGCTCATTACTATGCAGGTAAAACATATGATTACTATAAAGCTACGTTTAATAGAAATTCTATTAATGATGCAGG
AGCACCGTTAAAATCGACAGTTCATTACGGAAGTAATTATAACAATGCATTCTGGAACGGATCACAGATGGTATACGGAG
ATGGTGATGGTGTAACGTTTACTTCATTATCTGGTGGAATTGATGTAATTGGTCACGAGTTAACGCATGCTGTTACGGAA
AATAGTTCAAATCTAATTTATCAAAATGAATCTGGGGCTTTAAATGAAGCGATTTCTGATATCTTTGGTACTTTAGTAGA
ATTCTATGATAACCGTAACCCGGATTGGGAGATTGGTGAAGATATTTACACACCTGGTAAAGCAGGAGACGCACTTCGCT
CTATGAGTGATCCTACGAAGTATGGTGATCCAGACCATTATTCTAAGCGTTACACTGGTTCAAGTGATAACGGTGGTGTT
CATACAAACAGCGGCATTATTAATAAACAAGCTTATTTATTAGCAAATGGTGGTACGCATTATGGTGTAACTGTAACTGG
TATCGGTAAAGATAAATTAGGTGCGATTTACTACCGTGCAAATACACAGTATTTCACGCAATCTACTACATTTAGTCAAG
CTCGTGCTGGTGCAGTACAAGCTGCTGCAGACTTATATGGTGCAAATTCTGCTGAAGTAGCAGCAGTTAAGCAATCATTT
AGTGCTGTTGGTGTAAACTAA

Upstream 100 bases:

>100_bases
GAAAATAATTATTTGAATTTTTAGTATATTAATAGTGGAAACATAATGCTAATATAAAACTACTCTTTTTCAAAAAAATT
TTTTATTAGGGGGAAGGTTC

Downstream 100 bases:

>100_bases
GGCTTTAAGGAAGAGCTAGTAATAAAATACCTCAAAAATAAAGAAGGAGCATAGGCTCCTTCTTTATTTTTTTCTCCATT
TTTTCCACAAATAAAACAAT

Product: neutral protease Npr599

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTGATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQVKKDAVTDSTVVRMQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QQDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLDPSPGNYYYFIEADSGKVLNKFNTIDHVTNDDKSPVKQEAPK
QDAKAVVKPVTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRSTLPGTLWADADNVFNAAYDAAA
VDAHYYAGKTYDYYKATFNRNSINDAGAPLKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
NSSNLIYQNESGALNEAISDIFGTLVEFYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSSDNGGV
HTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSF
SAVGVN

Sequences:

>Translated_566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTGATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQVKKDAVTDSTVVRMQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QQDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLDPSPGNYYYFIEADSGKVLNKFNTIDHVTNDDKSPVKQEAPK
QDAKAVVKPVTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRSTLPGTLWADADNVFNAAYDAAA
VDAHYYAGKTYDYYKATFNRNSINDAGAPLKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
NSSNLIYQNESGALNEAISDIFGTLVEFYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSSDNGGV
HTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSF
SAVGVN
>Mature_566_residues
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTGATGKKAESVVFDYLNAAKGDYKLGEK
SAQDSFKVKQVKKDAVTDSTVVRMQQVYEGVPVWGSTQVAHVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIA
QQDLGVTPKYEVEPKADLYVYQNGEETTYAYVVNLNFLDPSPGNYYYFIEADSGKVLNKFNTIDHVTNDDKSPVKQEAPK
QDAKAVVKPVTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRSTLPGTLWADADNVFNAAYDAAA
VDAHYYAGKTYDYYKATFNRNSINDAGAPLKSTVHYGSNYNNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTE
NSSNLIYQNESGALNEAISDIFGTLVEFYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSSDNGGV
HTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQAAADLYGANSAEVAAVKQSF
SAVGVN

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 60848; Mature: 60848

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTGATGKKA
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
ESVVFDYLNAAKGDYKLGEKSAQDSFKVKQVKKDAVTDSTVVRMQQVYEGVPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIAQQDLGVTPKYEVEPKADLYV
EECCCCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
YQNGEETTYAYVVNLNFLDPSPGNYYYFIEADSGKVLNKFNTIDHVTNDDKSPVKQEAPK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHCCH
QDAKAVVKPVTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRSTL
HHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCC
PGTLWADADNVFNAAYDAAAVDAHYYAGKTYDYYKATFNRNSINDAGAPLKSTVHYGSNY
CCEEECCCHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCCCCHHHHEECCCCC
NNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISD
CCCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
IFGTLVEFYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSSDNGGV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCE
HTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQ
ECCCCEEECEEEEEECCCCEEEEEEEECCCCCCEEEEEEECCEEEEECCCHHHHHHHHHH
AAADLYGANSAEVAAVKQSFSAVGVN
HHHHHCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKKSLALVLATGMAVTTFGGTGSAFADSKNVLSTKKYNETVQSPEFISGDLTGATGKKA
CCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
ESVVFDYLNAAKGDYKLGEKSAQDSFKVKQVKKDAVTDSTVVRMQQVYEGVPVWGSTQVA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEEE
HVSKDGSLKVLSGTVAPDLDKKEKLKNKNKIEGAKAIEIAQQDLGVTPKYEVEPKADLYV
EECCCCCEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
YQNGEETTYAYVVNLNFLDPSPGNYYYFIEADSGKVLNKFNTIDHVTNDDKSPVKQEAPK
EECCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHCCH
QDAKAVVKPVTGTNKVGTGKGVLGDTKSLNTTLSGSSYYLQDNTRGATIFTYDAKNRSTL
HHHHHHEECCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCEEEEEECCCCCCC
PGTLWADADNVFNAAYDAAAVDAHYYAGKTYDYYKATFNRNSINDAGAPLKSTVHYGSNY
CCEEECCCHHHHHHHHHHHHCCCEEECCCCEEEEEEECCCCCCCCCCCCHHHHEECCCCC
NNAFWNGSQMVYGDGDGVTFTSLSGGIDVIGHELTHAVTENSSNLIYQNESGALNEAISD
CCCEECCCEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHH
IFGTLVEFYDNRNPDWEIGEDIYTPGKAGDALRSMSDPTKYGDPDHYSKRYTGSSDNGGV
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCE
HTNSGIINKQAYLLANGGTHYGVTVTGIGKDKLGAIYYRANTQYFTQSTTFSQARAGAVQ
ECCCCEEECEEEEEECCCCEEEEEEEECCCCCCEEEEEEECCEEEEECCCHHHHHHHHHH
AAADLYGANSAEVAAVKQSFSAVGVN
HHHHHCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1495388; 3092843; 3127592; 1633827 [H]