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The map label for this gene is moeA2 [H]

Identifier: 218235121

GI number: 218235121

Start: 3586529

End: 3587836

Strand: Reverse

Name: moeA2 [H]

Synonym: BCB4264_A3674

Alternate gene names: 218235121

Gene position: 3587836-3586529 (Counterclockwise)

Preceding gene: 218234160

Following gene: 218235675

Centisome position: 66.21

GC content: 38.91

Gene sequence:

>1308_bases
ATGGAAAGAAGAGTGCCAATTACGGTTGAAGAAGCTGTTCGTAAAGTGATGGGATTTGCTGATAAGGGCTTAAAGGAGCT
ATTACCAATTGAATTAGCTTATGGACGTATATTAGCAGAGGATTTAGTAGCTGACCATGATGTACCGTCATTTAATCGTT
CGCCGTATGACGGATTTGCTATTCGAGCAGAAGATACTAATTTAGCAAGTTATGAAACGCCAATTGTATTTGAAGTAGTG
GGTGAAATTGGTGCAGGATCGCTATTCCATGAGAAAGTAGGTCCATTTCAAGCAGTTCGAATTATGACAGGAGCACAAAT
TCCGAATGGGTGTGATGCGGTTGTTATGTTAGAGCTGACTCGTCAATATGAGAAGAATGGCAACAATTATATGGAAGTGA
AGCGATCATTCAAAACGGGCGACAATATTTCTTTTCAAGGTGAAGATGCTCGTAAAGGAACAGTTCTTGCAAAGAAGGGA
TCGTACATTAATCCAGGTATTTCAGCTCTTCTTGCTACATTCGGTTATAGCGAGGTGCCAGTGGCGAGAAAGCCTGTAAT
TGGATTGTTAGCGACCGGTAGTGAGTTACTGGATGTAAATGATTCCTTACAGCCAGGGAAAATCCGAAATAGTAATACGT
ATATGATATTGTCTCAAATTCGAAGAGCGGGCGGAAGAGTAAAATATTTTGGGAAGTTTAGCGACGACTTTGATACATGC
TTCTTAGCTGTAAAAGAAGCGTTAAGCCAAGTAGATATGCTCATTACAACAGGTGGCGTATCAGTTGGTGATTATGATCA
TTTACCGGCTATATATGAAAAGTTAGGTGCAACAGTTCTTTTTAATAAAGTTGCAATGCGCCCAGGGAGTGTTACGACTG
TAGCACAATTAAACGGAAAGTTATTATTTGGTTTATCAGGAAATCCATCAGCTTGTTACGTAGGGTTTGAATTATTTGTA
AGACCTTCTATTCGGACCTATATGTTTAGCGGAAAAGCACATTTAAAAAGAGAAAAAGCGTTATTAGGAGAAGATTTTCT
AAAACCGAATCCATTTACAAGATTTGTACGAGCAAAATTGCAATATGATGAGGGGAAATTAATCGCTTATCCATCAGGGT
TTGATAAATCTAGCTCGGTTTCTTCATTAGCAGAATCGAATGCTTTTATCGTATTGCCAGGCGGGACAAGAGGATATAAA
AAAGATATGTTTGTGGATGTTCTTTTATTGGAAGATAACGAGGGTAGTGAATGGCCTTGGACATTTTATAAAGTGAGAGG
TGGTTCCAATGGGACAAGCTCTATTTGA

Upstream 100 bases:

>100_bases
TTTTTCGGGATGGTCGTGTTTTTATTCATGGTACAAATGATATTTCGAAAGCGAAACAACTATATTATCGCGTATTCGGT
TAATAGAGAGGGTGTCAACA

Downstream 100 bases:

>100_bases
GATTGTTGATATACCGATTATAGTTGAAGAAGTAACGAATAAAGTCGCAAGAAGGGAAGCAGGTGCGATTACAACATTTA
TTGGTACGGTGAGAGAATTA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MERRVPITVEEAVRKVMGFADKGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFHEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEKNGNNYMEVKRSFKTGDNISFQGEDARKGTVLAKKG
SYINPGISALLATFGYSEVPVARKPVIGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFDTC
FLAVKEALSQVDMLITTGGVSVGDYDHLPAIYEKLGATVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPSIRTYMFSGKAHLKREKALLGEDFLKPNPFTRFVRAKLQYDEGKLIAYPSGFDKSSSVSSLAESNAFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGGSNGTSSI

Sequences:

>Translated_435_residues
MERRVPITVEEAVRKVMGFADKGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFHEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEKNGNNYMEVKRSFKTGDNISFQGEDARKGTVLAKKG
SYINPGISALLATFGYSEVPVARKPVIGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFDTC
FLAVKEALSQVDMLITTGGVSVGDYDHLPAIYEKLGATVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPSIRTYMFSGKAHLKREKALLGEDFLKPNPFTRFVRAKLQYDEGKLIAYPSGFDKSSSVSSLAESNAFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGGSNGTSSI
>Mature_435_residues
MERRVPITVEEAVRKVMGFADKGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFAIRAEDTNLASYETPIVFEVV
GEIGAGSLFHEKVGPFQAVRIMTGAQIPNGCDAVVMLELTRQYEKNGNNYMEVKRSFKTGDNISFQGEDARKGTVLAKKG
SYINPGISALLATFGYSEVPVARKPVIGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFDTC
FLAVKEALSQVDMLITTGGVSVGDYDHLPAIYEKLGATVLFNKVAMRPGSVTTVAQLNGKLLFGLSGNPSACYVGFELFV
RPSIRTYMFSGKAHLKREKALLGEDFLKPNPFTRFVRAKLQYDEGKLIAYPSGFDKSSSVSSLAESNAFIVLPGGTRGYK
KDMFVDVLLLEDNEGSEWPWTFYKVRGGSNGTSSI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=390, Percent_Identity=34.3589743589744, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI10880983, Length=389, Percent_Identity=34.4473007712082, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1787049, Length=370, Percent_Identity=34.8648648648649, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147659, Length=399, Percent_Identity=29.0726817042606, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=367, Percent_Identity=27.2479564032698, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136978, Length=370, Percent_Identity=30, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24638841, Length=370, Percent_Identity=30, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 47700; Mature: 47700

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRVPITVEEAVRKVMGFADKGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFHEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCHHHHHCCCHHEEEEEECCCCCCCCCEEEEHHHH
RQYEKNGNNYMEVKRSFKTGDNISFQGEDARKGTVLAKKGSYINPGISALLATFGYSEVP
HHHHHCCCCEEEHHHHHCCCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
VARKPVIGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFDTC
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCEEEHHHHHHCCCCEEEEECCCCCHHHH
FLAVKEALSQVDMLITTGGVSVGDYDHLPAIYEKLGATVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHCCCEEEHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPSIRTYMFSGKAHLKREKALLGEDFLKPNPFTRFVRAKL
EEEEECCCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHE
QYDEGKLIAYPSGFDKSSSVSSLAESNAFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCCEEEECCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGGSNGTSSI
EEEEEECCCCCCCCC
>Mature Secondary Structure
MERRVPITVEEAVRKVMGFADKGLKELLPIELAYGRILAEDLVADHDVPSFNRSPYDGFA
CCCCCCEEHHHHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEE
IRAEDTNLASYETPIVFEVVGEIGAGSLFHEKVGPFQAVRIMTGAQIPNGCDAVVMLELT
EEECCCCCCCCCCCCCEEEHHCCCCCCHHHHHCCCHHEEEEEECCCCCCCCCEEEEHHHH
RQYEKNGNNYMEVKRSFKTGDNISFQGEDARKGTVLAKKGSYINPGISALLATFGYSEVP
HHHHHCCCCEEEHHHHHCCCCCEEECCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCC
VARKPVIGLLATGSELLDVNDSLQPGKIRNSNTYMILSQIRRAGGRVKYFGKFSDDFDTC
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCEEEHHHHHHCCCCEEEEECCCCCHHHH
FLAVKEALSQVDMLITTGGVSVGDYDHLPAIYEKLGATVLFNKVAMRPGSVTTVAQLNGK
HHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHHCCCEEEHHHHCCCCCEEEEEECCCE
LLFGLSGNPSACYVGFELFVRPSIRTYMFSGKAHLKREKALLGEDFLKPNPFTRFVRAKL
EEEEECCCCCEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHE
QYDEGKLIAYPSGFDKSSSVSSLAESNAFIVLPGGTRGYKKDMFVDVLLLEDNEGSEWPW
EECCCCEEEECCCCCCCCHHHHHHHCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCCCE
TFYKVRGGSNGTSSI
EEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]