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The map label for this gene is panE2 [H]

Identifier: 218235016

GI number: 218235016

Start: 3946483

End: 3947373

Strand: Reverse

Name: panE2 [H]

Synonym: BCB4264_A4021

Alternate gene names: 218235016

Gene position: 3947373-3946483 (Counterclockwise)

Preceding gene: 218235991

Following gene: 218235759

Centisome position: 72.84

GC content: 35.13

Gene sequence:

>891_bases
GTGAAAATGAAAATTGGAATTGTCGGACCAGGTGCTATTGGTCTATTGTATACATTTTATTTACAAAAAAGTAACCAAGA
TGTTACGTTGTTTACAAGAACGGCTAAGCAGGCTGAAGAGTTGAATGAAACAGGTGTAACTTGTATTAGAGATGGAAGAT
GTGAAACAGTATATCCATCTGTTTTACCGATAGAAAGTATGGTAGCGCAAAATTTAGATTATATATTTATTTCTGTGAAG
CAATATCATATAGATGACGTACTACCGTTTGTGGAAGGGGCATCATCATTAATCTTTTTGCAAAACGGAATGTCGCATCT
TCAAAAGATGCTGAAAATAGGGAGTGAAAATATAGCTGTTGGTATTGTAGAACATGGTGCGAAAAAAGAGGGAGGGCATA
TCGTTCATCATACTGGGATAGGGGTAACAAAATTTGGAGTGGTTTGTGGTCAATCTATACATTTCAAAAAAATATTCCGT
TATTTTCCTGTTACTTATTTTCCAGTTCAAATAGAAACGGATTGGGAAGAGATTATGCACAAAAAATTAGTAGTAAATGT
ATGTATCAATCCATTGACAGCACTATTGGGAGTTAAGAATGGTGAATTAATCACGAATCGTTTTTTTTATCAAATGATGG
AGCAAGTGTTTCAGGAGGTCGCATTTCTTATTAGAGGAGAAAAAGAAATGGTATGGCAAATGGTACGAAATGTGTGTGAA
GGAACGTCTCGTAATACATCCTCTATGTTAGCGGATGTAAGAGCGAATAGACAGACGGAAATTAATGCGATTGTTGGATA
TGTATTAGAAGAAGCTAAGAAACAGCAACTACCAGTTCCGACACTTCAATTTTTGTTTGATGCAATAAAAGGGTTAGAAA
CAAGAGTATAA

Upstream 100 bases:

>100_bases
TTTGTTTGGCAGAGGACAACGAAATTATAGGGCGTGCTCATGTACTTTAAAAAGATATAAAAAGGAGGGGAGACAAGGGC
GCTTAATGTGAATCCCTTGT

Downstream 100 bases:

>100_bases
GTGTTATTCTTTGCTTTTACGTGAAACATTGACTACAATGTGGATTGGTGAGAGAACTGGATACGAAAGGAAGAATTATA
TGGAGATAAAAGAAATCTCT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPSVLPIESMVAQNLDYIFISVK
QYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAVGIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFR
YFPVTYFPVQIETDWEEIMHKKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCE
GTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV

Sequences:

>Translated_296_residues
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPSVLPIESMVAQNLDYIFISVK
QYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAVGIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFR
YFPVTYFPVQIETDWEEIMHKKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCE
GTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV
>Mature_296_residues
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPSVLPIESMVAQNLDYIFISVK
QYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAVGIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFR
YFPVTYFPVQIETDWEEIMHKKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCE
GTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=309, Percent_Identity=27.831715210356, Blast_Score=105, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 33397; Mature: 33397

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPS
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEECCCCCEECCC
VLPIESMVAQNLDYIFISVKQYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAV
CCCHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCEEE
GIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFRYFPVTYFPVQIETDWEEIMH
EEEECCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCHHHHHH
KKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKMKIGIVGPGAIGLLYTFYLQKSNQDVTLFTRTAKQAEELNETGVTCIRDGRCETVYPS
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCEEEECCCCCEECCC
VLPIESMVAQNLDYIFISVKQYHIDDVLPFVEGASSLIFLQNGMSHLQKMLKIGSENIAV
CCCHHHHHHCCCCEEEEEEEHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCEEE
GIVEHGAKKEGGHIVHHTGIGVTKFGVVCGQSIHFKKIFRYFPVTYFPVQIETDWEEIMH
EEEECCCCCCCCEEEEECCCCHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEECCHHHHHH
KKLVVNVCINPLTALLGVKNGELITNRFFYQMMEQVFQEVAFLIRGEKEMVWQMVRNVCE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
GTSRNTSSMLADVRANRQTEINAIVGYVLEEAKKQQLPVPTLQFLFDAIKGLETRV
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]