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The map label for this gene is hemZ [H]

Identifier: 218234955

GI number: 218234955

Start: 894977

End: 896464

Strand: Direct

Name: hemZ [H]

Synonym: BCB4264_A0926

Alternate gene names: 218234955

Gene position: 894977-896464 (Clockwise)

Preceding gene: 218231745

Following gene: 218235524

Centisome position: 16.52

GC content: 36.36

Gene sequence:

>1488_bases
TTGTTAATTTCAATTAAAACGTTACAAGATGATCGTTTTTTACGTCCGCTACAAAATATTGGCGGCTTATTTTTTGAAGA
TAGTACGATTGGATTTGAACAAGAGGAAGCAAATCTGATCGTTGATATACACATTGAGGATAATGTGAAAGCATCTGCTC
AATTGACGGATGTTAGCACAGGAAATGTGTATGAAGAAACATTCTCGAAAGATTTATCTGCTTTCACAGATGAAAAAGAG
CGTATGAAGCAAGTGAAGCACGTTGTTTCTTATGTATATCTTTCTGTTCTTCAGCAGTTAACTGGTATTGAACAAAGCTG
GGGTATTTTAACGGGAGTACGTCCGACGAAACTTCTTCACAAAATGCTTCAAAATGGTATGTCAAAAGAAGAAGCGCATC
AAGAACTTCGTGAAAGTTATTTAATTCATGAAGAGAAAATTGAACTTCTTCAGCGCATTGTTGATTGCCAATTAGCAGTT
GTTCCGGATTTATACCGTTTGAAAGAAGAAGTAAGTATTTATATCGGTATTCCGTTCTGCCCAACGAAATGTGCATACTG
TACATTCCCGGCTTATGCAATTAATGGACGCCAAGGATCTGTTGATTCGTTCTTAGGTGGTTTACATTATGAAGTTCGTG
AAATTGGTAAGTTTTTAAAAGAAAAAGGTGTAAAAGTTACGACGATTTATTACGGCGGCGGTACACCTACAAGTATTACA
GCAGAAGAGATGGATATGCTGTATGAAGAAATGTATGAAGCGTTCCCAGATGTGAAAAATGTGCGTGAAGTAACAGTTGA
GGCAGGTCGCCCAGATACGATTACTCCAGCAAAGCTAGAAGTGTTAAATAAATGGAATATTGACCGTATTAGTATTAATC
CGCAGTCATACCATCAAGAGACACTAAAAGCAATTGGACGTCATCATACTGTAGAAGAAACAATCGAGAAATACCATTTA
GCTCGTGAAATGGGAATGAACAATATTAATATGGACTTAATTATTGGTCTTCCTGGTGAAGGGTTAGATATCTTCAAGCA
TACGTTAGATGAAACAGAAAAGTTAATGCCAGAATCATTAACAGTTCATACGTTATCATTTAAACGTGCTTCTGAAATGA
CGCAAAACAAACGTAAATATAAAGTAGCAGGTCGCGAAGAAATTACAGCGATGATGCACGAAGCAGAAGAGTGGACGCAA
AAGCATAATTACGTACCATATTACCTATATCGTCAAAAGAATATTTTAGGTAACTTAGAGAATGTTGGTTATGCAATGCC
GACGCAAGAAAGTATTTACAACATTGTCATTATGGAAGAAGTACAATCAATTATCGGACTTGGTTGTGGTGCATCAAGTA
AATTTGTTCATCCGAAGACGGGAGCAATTACTCACTTCGCAAATCCGAAAGATCCAAAATCATATAACGATGGCTTTGTG
AAATATACAGAAGATAAACTGAAAATTTTAGAAGAGCTATTTGCATAA

Upstream 100 bases:

>100_bases
TTTGAAAAAATGTAAGAGAAACAGGTAAAACCTTCTGTATTGACCTGTAAACGCCCTTCAAGTAAACTAAAGAGAGTTTG
CAAATGAAAAGGTGATAATG

Downstream 100 bases:

>100_bases
GAAGAAAGAGGTTGTTCCGAGTCGGAACAACCTCTTTTTTATCCTGCAGTAACGGGCGGTCCGATTATATCTTGTCAGTT
TTTGTCGGTAAGTCGATATA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEDNVKASAQLTDVSTGNVYEETFSKDLSAFTDEKE
RMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAV
VPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSIT
AEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
AREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQ
KHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGFV
KYTEDKLKILEELFA

Sequences:

>Translated_495_residues
MLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEDNVKASAQLTDVSTGNVYEETFSKDLSAFTDEKE
RMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAV
VPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSIT
AEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
AREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQ
KHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGFV
KYTEDKLKILEELFA
>Mature_495_residues
MLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEDNVKASAQLTDVSTGNVYEETFSKDLSAFTDEKE
RMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLHKMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAV
VPDLYRLKEEVSIYIGIPFCPTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSIT
AEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQETLKAIGRHHTVEETIEKYHL
AREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESLTVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQ
KHNYVPYYLYRQKNILGNLENVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGFV
KYTEDKLKILEELFA

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=302, Percent_Identity=24.1721854304636, Blast_Score=83, Evalue=7e-16,
Organism=Escherichia coli, GI1789325, Length=322, Percent_Identity=26.3975155279503, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082341, Length=192, Percent_Identity=28.125, Blast_Score=86, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 56564; Mature: 56564

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEDNVKASAQLTDVST
CEEEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCC
GNVYEETFSKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLH
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHHHHH
KMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
PTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSIT
CCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQE
HHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHHHHH
TLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHH
NVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGFV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCE
KYTEDKLKILEELFA
EECHHHHHHHHHHHC
>Mature Secondary Structure
MLISIKTLQDDRFLRPLQNIGGLFFEDSTIGFEQEEANLIVDIHIEDNVKASAQLTDVST
CEEEEEECCCCHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCC
GNVYEETFSKDLSAFTDEKERMKQVKHVVSYVYLSVLQQLTGIEQSWGILTGVRPTKLLH
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHCCCCHHHHHH
KMLQNGMSKEEAHQELRESYLIHEEKIELLQRIVDCQLAVVPDLYRLKEEVSIYIGIPFC
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCC
PTKCAYCTFPAYAINGRQGSVDSFLGGLHYEVREIGKFLKEKGVKVTTIYYGGGTPTSIT
CCCCCEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
AEEMDMLYEEMYEAFPDVKNVREVTVEAGRPDTITPAKLEVLNKWNIDRISINPQSYHQE
HHHHHHHHHHHHHHCCCHHHHHHHHEECCCCCCCCHHHHHHHHCCCCEEEEECHHHHHHH
TLKAIGRHHTVEETIEKYHLAREMGMNNINMDLIIGLPGEGLDIFKHTLDETEKLMPESL
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCE
TVHTLSFKRASEMTQNKRKYKVAGREEITAMMHEAEEWTQKHNYVPYYLYRQKNILGNLE
EEEEEHHHHHHHHHHCCHHEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCCHH
NVGYAMPTQESIYNIVIMEEVQSIIGLGCGASSKFVHPKTGAITHFANPKDPKSYNDGFV
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCE
KYTEDKLKILEELFA
EECHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]