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The map label for this gene is glmS [H]

Identifier: 218234817

GI number: 218234817

Start: 163648

End: 165450

Strand: Direct

Name: glmS [H]

Synonym: BCB4264_A0191

Alternate gene names: 218234817

Gene position: 163648-165450 (Clockwise)

Preceding gene: 218233725

Following gene: 218231403

Centisome position: 3.02

GC content: 39.16

Gene sequence:

>1803_bases
ATGTGTGGAATCGTAGGATTTATTGGAGAGCAAGATGCAAAGGAAATTTTATTAAAAGGTTTAGAAAAGCTAGAATATCG
TGGATATGATTCAGCAGGTATTGCAGTACAAGCAGAGAACGGTGTTGTTGTATACAAAGAAAAAGGCCGTATCGCAAAAC
TTCGTGAAATCGTAGATGAGAACGTAGCAGCAAGCGTAGGTATCGGACACACACGCTGGGCTACACACGGTGTTCCAAGT
AAGGTAAACGCGCATCCGCATCAAAGTACATCAAAACGCTTTACATTAGTTCATAACGGTGTAATTGAAAACTATGAATT
AGTGAAAAAGGAATATTTACAAGATGTAACGTTCGTAAGTGAAACAGATACAGAGGTTATCGTACAGCTTATGGAACAAC
AAGTGAGCACAGGATTAAGTGTAGAAGAAGCGTTCCGTAATACGCTATCTCTTTTACATGGCTCTTATGCAATCGGATTA
CTTGATGCTGAAAATCCAAACATGATTTATGTTGCTAAAAACAAAAGCCCGCTATTAGTAGGTGTTGGTGACAACTTTAA
TGTTGTGGCAAGCGACGCTATGGCGATGTTACAAGTTACAGATCAATTTATTGAGCTAATGGATAAAGAAATCGTAATCG
TAACGAAAGAAAGTATTACAATTAAAAACTTACAAGGTGAAACGATTGAACGTGCACCGTTTACAGCGGAATTAGACGCA
AGTGATATTGAAAAGGGAACATATCCTCATTTCATGCTTAAAGAAATCGATGAGCAACCACTTGTAATCCGTAATATAAT
TCAAAAGTATCAAGATGAAAATGGCGAAATTGAATTAAATCAAGACATCCGCAATGCGATTTTAGATAGCGATCGTATTT
ACATCATTGCATGTGGAACGAGTTATCATGCAGGTCTTGTTGGAAAACAATTTATCGAGAAGTTTGCAAAAATGCCAGTT
GAAGTACACGTGGCAAGTGAATTCTCTTACAACATGCCATTATTAACAGAAAGACCATTCTTCATTTACATTTCACAAAG
TGGTGAAACAGCTGATAGCCGTGCAGTACTTGTGCAAACAAATGAAATGGGCCATAAAGCATTAACAATTACAAACGTGC
CTGGTTCTACGCTTTCTCGTGAAGCTGATTATACACTTCCGTTATACGCTGGACCAGAAATTGCAGTTGCATCAACGAAA
GCTTACACAGCACAGCTTGCAGTACTTTCAATTTTAGCGGCTGATATTGCTAAAGCAAAAGGTGAAGTTCTTGATTTCGA
TTTAACACACGAACTAGGACTTGTAGCAAATGCAATGATAGAACTTTGTGATCAAAAAGAAGAAATGGACGCATTAGCAA
AACAATTTTTAGCGACAACGCGTAACTGTTTCTTCATCGGACGTAGCGTAGACTTCTACGTAGGATTAGAAGGTGCGTTA
AAACTAAAAGAAATCTCTTACATCCAAGCAGAAGGATTCGCTGGAGGAGAGTTAAAACACGGTACAATCGCTTTAATCGA
AAATGGTACACCAGTTATCGCACTTGCTACACAAGAGCACGTAAACCTTGGAATTCGTGGTAACGTGAAAGAAGTAGTAG
CACGCGGGGCTAACCCATGTATCATTTCAATGAAAGGCTTAGAAATGGAAGGTGACAGCTTCGTATTACCAGCTGTACAC
GAAGCGCTAGCACCGCTAGTAGCAGTTATTCCATTACAACTTATCTCATACTACGCAGCACTTCACCGCGAGTGTGACGT
TGATAAGCCACGTAACTTAGCTAAGTCTGTTACTGTTGAGTAG

Upstream 100 bases:

>100_bases
AGCAATATGTAATCCGTTTTTTAGTATAAATAAAAATGGTATCGGACTATGTCGTTACATGTTCGCAGAGCAGTGTAAGC
ATTTGTAACGGCGACTAAAC

Downstream 100 bases:

>100_bases
GAGATTGGTAGGTTAATAAGTATAGTTATACGTTTGAAATAAATTAAAACTAAGAAAAAACTCTGTAAAAATCATTTTAC
AGAGTTTTTTTAGTTATTTA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 600; Mature: 600

Protein sequence:

>600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVAASVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE

Sequences:

>Translated_600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVAASVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
>Mature_600_residues
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDENVAASVGIGHTRWATHGVPS
KVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVSETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGL
LDAENPNMIYVAKNKSPLLVGVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGTSYHAGLVGKQFIEKFAKMPV
EVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQTNEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTK
AYTAQLAVLSILAADIAKAKGEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPCIISMKGLEMEGDSFVLPAVH
EALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=33.4795321637427, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=32.798833819242, Blast_Score=326, Evalue=4e-89,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=41.7618270799347, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI87082251, Length=306, Percent_Identity=22.5490196078431, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788651, Length=242, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17532899, Length=721, Percent_Identity=28.9875173370319, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17539970, Length=436, Percent_Identity=35.7798165137615, Blast_Score=229, Evalue=4e-60,
Organism=Caenorhabditis elegans, GI17532897, Length=444, Percent_Identity=34.009009009009, Blast_Score=216, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6322745, Length=428, Percent_Identity=33.8785046728972, Blast_Score=230, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6323731, Length=391, Percent_Identity=29.923273657289, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=36.5853658536585, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357745, Length=689, Percent_Identity=32.8011611030479, Blast_Score=335, Evalue=7e-92,
Organism=Drosophila melanogaster, GI28573187, Length=266, Percent_Identity=25.5639097744361, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65793; Mature: 65793

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDE
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHC
NVAASVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVS
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEC
ETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
ECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCEECCCCEEECCH
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCEEEEEECC
SYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEE
NEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAK
CCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
CCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCE
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHHEEECCCCCHHHHHHCCCCCE
IISMKGLEMEGDSFVLPAVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
EEEEECCEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGFIGEQDAKEILLKGLEKLEYRGYDSAGIAVQAENGVVVYKEKGRIAKLREIVDE
CCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHC
NVAASVGIGHTRWATHGVPSKVNAHPHQSTSKRFTLVHNGVIENYELVKKEYLQDVTFVS
CCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHEEC
ETDTEVIVQLMEQQVSTGLSVEEAFRNTLSLLHGSYAIGLLDAENPNMIYVAKNKSPLLV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCEEE
GVGDNFNVVASDAMAMLQVTDQFIELMDKEIVIVTKESITIKNLQGETIERAPFTAELDA
ECCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCCEECCCCEEECCH
SDIEKGTYPHFMLKEIDEQPLVIRNIIQKYQDENGEIELNQDIRNAILDSDRIYIIACGT
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCEEEEEECC
SYHAGLVGKQFIEKFAKMPVEVHVASEFSYNMPLLTERPFFIYISQSGETADSRAVLVQT
CCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCEEEEEE
NEMGHKALTITNVPGSTLSREADYTLPLYAGPEIAVASTKAYTAQLAVLSILAADIAKAK
CCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHCC
GEVLDFDLTHELGLVANAMIELCDQKEEMDALAKQFLATTRNCFFIGRSVDFYVGLEGAL
CCEEEEECHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEECCEEEEEECCCCE
KLKEISYIQAEGFAGGELKHGTIALIENGTPVIALATQEHVNLGIRGNVKEVVARGANPC
EEEHEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEHHHEEECCCCCHHHHHHCCCCCE
IISMKGLEMEGDSFVLPAVHEALAPLVAVIPLQLISYYAALHRECDVDKPRNLAKSVTVE
EEEEECCEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]