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The map label for this gene is ampC [C]

Identifier: 218234725

GI number: 218234725

Start: 3025803

End: 3027026

Strand: Reverse

Name: ampC [C]

Synonym: BCB4264_A3147

Alternate gene names: 218234725

Gene position: 3027026-3025803 (Counterclockwise)

Preceding gene: 218234244

Following gene: 218234120

Centisome position: 55.86

GC content: 38.73

Gene sequence:

>1224_bases
GTGTGGTTAGCATATGACATAGCTATTAACCATCAATACAATTTAAATAGAAGAGAGGAATTCTTTATGAAAACACGCAG
TAAAATTACATGTGCAAGTCTAGCACTTTTAATAGCTGGAAGTTCCCTGTTATACATAACACCAACATTAATTGTAAAAG
CAGAACCTACGCAAAATGTATCTAGTTCGTTACAAACAAGTACGCAAAGCGATCGTACTTCTGTTAAGAAAGCAATGCGA
GATGAACTGCAACTTGGATACCCGGGAATACTCGCTAAAATTTCTAAGGGGGGTAAAACTTGGAGTTATAGTGCTGGGGT
AGCGGATTTGAAAACTAAGAAACCAATGAAAGCAGATTTTCGCTTTCGCATTGGCAGTGTGACGAAAACGTTCATTGCAA
CAGTTCTACTTCAATTATCTGGAGAGAACCGTTTGAATCTAGACGACTCCATTGAAAAATGGTTACCTGGTGTTATTCAA
GGAAACGGATATGATGGTAACCAGATTACGATCCGGCAAATATTGAATCATACAAGTGGTATTGCTGACTATATAAATTC
AAAAGACTTTGATATTACGGATATAAAAAAATCGTATACGGCTGAAGAATTTGTAAAGATGGGGATTTCACTTCCCCCAG
ACTTTGCCCCAGGAAAGGGTTGGTCTTATTCAAATACAGGATATGTAATACTAGGAATCCTTATTGAAAAAGTAACAGGA
AACAGCTATGAGGAAGAGGTTGAAAATCGGATTATTGAACCGCTTGATTTGTCAAATACATTTCTACCTGGTAATTCAAG
CGTGATTCCAGGCACCAAGCATGCCCGTGGCTATTTGCAACTAGACGGAGCGAGTGAGCTAAAAGATGTTACTTATATTA
ACCCAGGTAGCTCGGATGGAGATATGATTTCTACTGCTGACGACTTAAACAAATTCTTTTCTTGCTTACTAGGTGGCAAA
TTACTGAAGGAACAGCAGTTAAAACAAATGCTTACTACAGTTCCTACAAATAGAGAGGGAACCGGATATGGTCTTGGAAT
ACTTGAAATTAAGCTTCCGAACGGTGTCTCGGTATGGGGACACAGGGGGGCCGTTCCAGGGTTTTCCACTTTTGCTGGTG
GAACACTTGGAGGTAAACATACACTCGCTATCAATTCGAACAGTTTAAACATTAATAACCCGGAAGTTTTTAAAAACATT
TTACTTGCTGAATTTAGCAAGTAG

Upstream 100 bases:

>100_bases
TTTAGAGATTGTTAGAACACAATGGTGTTTGTGAAAATAATGATTAGTACGTTGATTGCAAATTCAGTGTTGACTTTTAT
CATTGGGAGAGTTGATAGCT

Downstream 100 bases:

>100_bases
GAAAAACGGATAAATTTTGTCATTTGTAATTTCCATCGGAATGGATTACCGCTTGAAAGAGTATAGAGGGATTGAGTATC
TAGAAACAATCAAGCCAATT

Product: putative D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MWLAYDIAINHQYNLNRREEFFMKTRSKITCASLALLIAGSSLLYITPTLIVKAEPTQNVSSSLQTSTQSDRTSVKKAMR
DELQLGYPGILAKISKGGKTWSYSAGVADLKTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQ
GNGYDGNQITIRQILNHTSGIADYINSKDFDITDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTG
NSYEEEVENRIIEPLDLSNTFLPGNSSVIPGTKHARGYLQLDGASELKDVTYINPGSSDGDMISTADDLNKFFSCLLGGK
LLKEQQLKQMLTTVPTNREGTGYGLGILEIKLPNGVSVWGHRGAVPGFSTFAGGTLGGKHTLAINSNSLNINNPEVFKNI
LLAEFSK

Sequences:

>Translated_407_residues
MWLAYDIAINHQYNLNRREEFFMKTRSKITCASLALLIAGSSLLYITPTLIVKAEPTQNVSSSLQTSTQSDRTSVKKAMR
DELQLGYPGILAKISKGGKTWSYSAGVADLKTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQ
GNGYDGNQITIRQILNHTSGIADYINSKDFDITDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTG
NSYEEEVENRIIEPLDLSNTFLPGNSSVIPGTKHARGYLQLDGASELKDVTYINPGSSDGDMISTADDLNKFFSCLLGGK
LLKEQQLKQMLTTVPTNREGTGYGLGILEIKLPNGVSVWGHRGAVPGFSTFAGGTLGGKHTLAINSNSLNINNPEVFKNI
LLAEFSK
>Mature_407_residues
MWLAYDIAINHQYNLNRREEFFMKTRSKITCASLALLIAGSSLLYITPTLIVKAEPTQNVSSSLQTSTQSDRTSVKKAMR
DELQLGYPGILAKISKGGKTWSYSAGVADLKTKKPMKADFRFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQ
GNGYDGNQITIRQILNHTSGIADYINSKDFDITDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTG
NSYEEEVENRIIEPLDLSNTFLPGNSSVIPGTKHARGYLQLDGASELKDVTYINPGSSDGDMISTADDLNKFFSCLLGGK
LLKEQQLKQMLTTVPTNREGTGYGLGILEIKLPNGVSVWGHRGAVPGFSTFAGGTLGGKHTLAINSNSLNINNPEVFKNI
LLAEFSK

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=272, Percent_Identity=24.6323529411765, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87082101, Length=238, Percent_Identity=24.7899159663866, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=313, Percent_Identity=26.1980830670927, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533026, Length=356, Percent_Identity=26.4044943820225, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565630, Length=243, Percent_Identity=27.9835390946502, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 44538; Mature: 44538

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLAYDIAINHQYNLNRREEFFMKTRSKITCASLALLIAGSSLLYITPTLIVKAEPTQNV
CEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHH
SSSLQTSTQSDRTSVKKAMRDELQLGYPGILAKISKGGKTWSYSAGVADLKTKKPMKADF
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCC
RFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSG
EEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHH
IADYINSKDFDITDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTG
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCC
NSYEEEVENRIIEPLDLSNTFLPGNSSVIPGTKHARGYLQLDGASELKDVTYINPGSSDG
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCC
DMISTADDLNKFFSCLLGGKLLKEQQLKQMLTTVPTNREGTGYGLGILEIKLPNGVSVWG
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEECC
HRGAVPGFSTFAGGTLGGKHTLAINSNSLNINNPEVFKNILLAEFSK
CCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MWLAYDIAINHQYNLNRREEFFMKTRSKITCASLALLIAGSSLLYITPTLIVKAEPTQNV
CEEEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCCHHH
SSSLQTSTQSDRTSVKKAMRDELQLGYPGILAKISKGGKTWSYSAGVADLKTKKPMKADF
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCC
RFRIGSVTKTFIATVLLQLSGENRLNLDDSIEKWLPGVIQGNGYDGNQITIRQILNHTSG
EEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHH
IADYINSKDFDITDIKKSYTAEEFVKMGISLPPDFAPGKGWSYSNTGYVILGILIEKVTG
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCC
NSYEEEVENRIIEPLDLSNTFLPGNSSVIPGTKHARGYLQLDGASELKDVTYINPGSSDG
CCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCCC
DMISTADDLNKFFSCLLGGKLLKEQQLKQMLTTVPTNREGTGYGLGILEIKLPNGVSVWG
CCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEECC
HRGAVPGFSTFAGGTLGGKHTLAINSNSLNINNPEVFKNILLAEFSK
CCCCCCCCHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]