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The map label for this gene is purL [H]

Identifier: 218234715

GI number: 218234715

Start: 313639

End: 315858

Strand: Direct

Name: purL [H]

Synonym: BCB4264_A0340

Alternate gene names: 218234715

Gene position: 313639-315858 (Clockwise)

Preceding gene: 218231005

Following gene: 218231603

Centisome position: 5.79

GC content: 40.5

Gene sequence:

>2220_bases
ATGTCGTTAATGCTTGAACCAAATCCAACACAAATTAAAGAAGAGCGTATATATGCGGAAATGGGGCTAACAGACGAAGA
GTTTGCCATGGTTGAAAAGATTTTAGGTCGTCTGCCAAATTATACAGAAACAGGGTTATTCTCTGTAATGTGGTCTGAAC
ATTGTAGTTATAAAAATTCAAAACCAGTTCTTCGTAAGTTTCCAACTACAGGTGAGCGCGTTCTGCAAGGACCTGGAGAA
GGTGCTGGAATTGTAGATATCGGTGATAATCAAGCAGTTGTATTTAAAATGGAAAGTCATAACCATCCTTCAGCTATTGA
ACCATATCAAGGAGCTGCAACAGGTGTTGGTGGTATTATTCGTGACGTATTCTCTATGGGAGCACGCCCGGTAGCTCTAT
TAAACTCACTTCGTTTCGGTGAATTACAGTCACCACGTGTGAAATATTTATTCGAAGAAGTAGTAGCAGGAATTGCAGGA
TACGGTAACTGCATCGGTATTCCGACTGTTGGCGGCGAAGTACAATTTGATCCATGTTATGAAGGAAATCCACTTGTAAA
TGCAATGTGCGTAGGTTTGATTAACCACGAAGACATTAAAAAAGGGCAAGCGCACGGTGCTGGTAACACAGTAATGTACG
TAGGAGCATCAACTGGTCGTGACGGTATTCACGGTGCAACATTCGCGTCGGAAGAACTATCTGAAAGCTCAGAAGCGAAA
CGTCCAGCGGTTCAAGTAGGGGATCCATTTATGGAAAAGCTTCTTATTGAAGCGTGTTTAGAATTAATTCAATCCGATGC
ACTTGTTGGAATTCAAGATATGGGTGCGGCTGGTTTAACATCATCATCTGCAGAAATGGCAAGTAAAGCAGGAATGGGTA
TTGAAATGTACTTAGATGATGTACCACAGCGTGAAACAGGAATGACACCATATGAAATGATGCTATCTGAATCACAAGAG
CGTATGTTAATTGTCGTGAAAAAAGGTAGAGAACAAGAAATAGTAGATTTATTTGAGAAGTATGGTCTTGCAGCGGTTAC
GATGGGGAAAGTAACAGAAGATAAAATGCTTCGTTTATTCCATAAAGGTGAAAAGGTAGCTGAAGTTCCAGCAGATGCTT
TAGCAGAAGAAGCACCAATTTATCATAAGCCATCAAAAGAAGCAGCATACTTTGCTGAATTCCAAGCAATGAAAATGGAA
ACGCCAAAAGTAGAAAATTATAAAGAAACGTTATTCGCTTTATTACAGCAACCAACAATTGCAAGTAAAGAGTGGGTATA
CGATCAATACGATTACCAAGTTCGCACAAGCACAGTTGTTACGCCAGGTTCAGATGCTGCAGTTGTACGTGTACGCGGTA
CAGAAAAAGGATTAGCAATGACGACAGATTGTAACTCTCGCTACATTTATCTAGACCCAGAGATGGGCGGTAAAATTGCA
GTAGCAGAGGCAGCGCGTAATATCGTATGTTCTGGCGGAGAGCCACTTGCAATTACAGATTGCTTAAACTTCGGTAACCC
AGAAAAACCAGAAATCTTCTGGCAGATTGAGAAATCAGTAGACGGTATGAGTGAAGCTTGTCGCACATTACAAACACCAG
TTATCGGCGGAAACGTATCGATGTATAACGAGCGTAGTGGTGAAGCTGTATATCCAACACCAACTGTTGGGATGGTCGGA
CTTGTGCATGACTTAAAACATGTAACAACACAAGAGTTTAAGCAAGCTGGTGATTTAGTGTATGTAATTGGTGAGACGAA
AGCTGAGTTTGGCGGAAGTGAATTACAGAAAATGATTCACGGCAAAATTTTCGGTCAATCACCAAGTATCGATTTAGATG
TAGAATTAAAACGCCAAAAACAAGTATTAGAAGCAATTCAAGCTGGTCTTGTTCAATCTGCACATGATGTTGCTGAAGGT
GGTTTAGCAGTTGCGATTTCAGAAAGTGCAATTGGTGCTAAAGGCTTAGGTGCTACTGTGAAATTAGATGGAGAAGCAAC
AGCAGCATTATTCGCTGAATCACAGTCACGCTTCGTGATAACTGTAAAACGTGAAAATAAAGAGGCGTTTGAAAAAGCGG
TAGAAGCAATCCAAGTTGGAGAAGTAACAAGTACAAATGAAGTAACAATTCATAATGAAGAAAATGAAGTATTACTTACA
GCAAATGTAGATGAAATGAGAAAGGCTTGGAAAGGGGCAATCCCATGCTTGCTGAAATAA

Upstream 100 bases:

>100_bases
GGTATGATGCCGCACCCAGAGCGTGCTGTAGATGAATTACTTGGCGGTGCTGAAGGGTTAAAAGTCTTTCAATCTATCTT
AAAACAGTGGAGGGAAACAT

Downstream 100 bases:

>100_bases
AGGGGTTAAACGAAGAATGTGGCGTTTTCGGAATTTGGGGGCATGAAAATGCAGCACAAGTTTCATACTACGGATTGCAC
AGTTTACAGCACCGTGGGCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MSLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGE
GAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAG
YGNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAK
RPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQE
RMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLFHKGEKVAEVPADALAEEAPIYHKPSKEAAYFAEFQAMKME
TPKVENYKETLFALLQQPTIASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEMGGKIA
VAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVSMYNERSGEAVYPTPTVGMVG
LVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIHGKIFGQSPSIDLDVELKRQKQVLEAIQAGLVQSAHDVAEG
GLAVAISESAIGAKGLGATVKLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTSTNEVTIHNEENEVLLT
ANVDEMRKAWKGAIPCLLK

Sequences:

>Translated_739_residues
MSLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGE
GAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAG
YGNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAK
RPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQE
RMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLFHKGEKVAEVPADALAEEAPIYHKPSKEAAYFAEFQAMKME
TPKVENYKETLFALLQQPTIASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEMGGKIA
VAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVSMYNERSGEAVYPTPTVGMVG
LVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIHGKIFGQSPSIDLDVELKRQKQVLEAIQAGLVQSAHDVAEG
GLAVAISESAIGAKGLGATVKLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTSTNEVTIHNEENEVLLT
ANVDEMRKAWKGAIPCLLK
>Mature_738_residues
SLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGEG
AGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGY
GNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAKR
PAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQER
MLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLFHKGEKVAEVPADALAEEAPIYHKPSKEAAYFAEFQAMKMET
PKVENYKETLFALLQQPTIASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEMGGKIAV
AEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVSMYNERSGEAVYPTPTVGMVGL
VHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIHGKIFGQSPSIDLDVELKRQKQVLEAIQAGLVQSAHDVAEGG
LAVAISESAIGAKGLGATVKLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTSTNEVTIHNEENEVLLTA
NVDEMRKAWKGAIPCLLK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Homo sapiens, GI31657129, Length=723, Percent_Identity=24.3430152143845, Blast_Score=112, Evalue=2e-24,
Organism=Escherichia coli, GI48994899, Length=764, Percent_Identity=25.6544502617801, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553022, Length=680, Percent_Identity=21.9117647058824, Blast_Score=101, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321498, Length=738, Percent_Identity=23.3062330623306, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24582111, Length=637, Percent_Identity=24.1758241758242, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24582109, Length=637, Percent_Identity=24.1758241758242, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137292, Length=637, Percent_Identity=24.1758241758242, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80193; Mature: 80062

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNS
CCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
KPVLRKFPTTGERVLQGPGEGAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDPCY
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAK
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
RPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDD
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHHHHHCCCCEEEEECC
VPQRETGMTPYEMMLSESQERMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
HKGEKVAEVPADALAEEAPIYHKPSKEAAYFAEFQAMKMETPKVENYKETLFALLQQPTI
HCCCHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
ASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEMGGKIA
CCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEEE
VAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVS
EEHHHCCEEECCCCCEEEEEHHCCCCCCCCEEEEEEHHHHCHHHHHHHHHCCCEECCCEE
MYNERSGEAVYPTPTVGMVGLVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIH
EECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHHH
GKIFGQSPSIDLDVELKRQKQVLEAIQAGLVQSAHDVAEGGLAVAISESAIGAKGLGATV
HHEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEE
KLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTSTNEVTIHNEENEVLLT
EECCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
ANVDEMRKAWKGAIPCLLK
ECHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNS
CEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCC
KPVLRKFPTTGERVLQGPGEGAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGII
CCHHHHCCCCCHHHHCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
RDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDPCY
HHHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEECCCC
EGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAK
CCCCHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHC
RPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDD
CCCEECCCHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCCCCHHHHHHHCCCCEEEEECC
VPQRETGMTPYEMMLSESQERMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLF
CCCCCCCCCHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
HKGEKVAEVPADALAEEAPIYHKPSKEAAYFAEFQAMKMETPKVENYKETLFALLQQPTI
HCCCHHHHCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
ASKEWVYDQYDYQVRTSTVVTPGSDAAVVRVRGTEKGLAMTTDCNSRYIYLDPEMGGKIA
CCCCCCCCCCCEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCCCEEEEECCCCCCEEE
VAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRTLQTPVIGGNVS
EEHHHCCEEECCCCCEEEEEHHCCCCCCCCEEEEEEHHHHCHHHHHHHHHCCCEECCCEE
MYNERSGEAVYPTPTVGMVGLVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIH
EECCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHCCHHHHHHHHH
GKIFGQSPSIDLDVELKRQKQVLEAIQAGLVQSAHDVAEGGLAVAISESAIGAKGLGATV
HHEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEE
KLDGEATAALFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTSTNEVTIHNEENEVLLT
EECCCCEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEE
ANVDEMRKAWKGAIPCLLK
ECHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA