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The map label for this gene is czcD [H]

Identifier: 218234643

GI number: 218234643

Start: 1679035

End: 1679934

Strand: Direct

Name: czcD [H]

Synonym: BCB4264_A1771

Alternate gene names: 218234643

Gene position: 1679035-1679934 (Clockwise)

Preceding gene: 218236152

Following gene: 218232666

Centisome position: 30.98

GC content: 36.78

Gene sequence:

>900_bases
ATGGGACATTCGCATGATCATGGTCATTCAAAAAATAAAAAGGCGTTACTAATTGCCTTCCTACTAACAACAAGTTTTAT
GATTGCAGAAGTTGTTGGTGGATTTGTAACAAATAGCTTAGCACTACTATCTGACGCGGGGCATATGCTAAGTGATGCAG
TATCTTTAGCTTTAAGTTTACTTGCGTTTAAGCTCGGAGAAAAAACAGCAACAACTGCGAAAACATACGGGTATAAGCGG
GTCGAAATGTTAGCAGCATTATGTAACGGTGTGGTTCTTATTGTCATTTCGGTATACATTTTTATTGAAGCAATCCGTCG
TTTTAAAGAACCAGTTGAGATTGCTAGTAATGGGATGCTCATTATTGCAGTCCTTGGTCTGCTTATTAATATTTTATCAG
CTTGGATATTAATGAGAGGCGGAGATGTGAAAGGTAATTTGAATTTAAGAAGTGCTTTCCTGCACGTACTAGGCGATCTA
TTGGGTTCCGTCGGAGCAATCATTGCTGCGTTACTTATTAAATTTTTCGGATGGACTGCTGCAGATGCGATTGCTAGTAT
TCTTGTGTCTATTTTAGTCATTATTAGTGGATGGCGTGTAACACGTGATACGGTTCATATATTAATGGAAGGTGCACCAC
AGCACATAAATGTTGAAGAGGTAAAAAGTACGTTATTAAATATTCCGATTGTCAAAGAAGTTCATGATTTGCACATATGG
TCTGTCACATCAGATTTTCAAGTATTAACATGTCATCTTATTATTAAAGGGAATGAAACGCAAAGTGTATTAAAAGAGGC
TACGTATGTATTAAAGGAGAAATTTCATGTAGAACATGTCACCATTCAAGTAGAAATAGATGGTGAATTTCATCACGATG
AGACAACTTGCAAAGTATGA

Upstream 100 bases:

>100_bases
TAGATAGAGGAAGCGGACGTTTATGGGCGTTAATTCGGGATAAACACGGGGAGTTTGTTTCATACTAACATACAGATATT
ACACTTAAAGGAGCATTCGT

Downstream 100 bases:

>100_bases
GAGAATAAGGATAAGAAAAAGTGTCATAACATTTTTCGCACGGCATACATATATATAATGTGGCCACAAATACTTTGCAA
GGTAAATATTTCATGAAATT

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MGHSHDHGHSKNKKALLIAFLLTTSFMIAEVVGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKR
VEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNIPIVKEVHDLHIW
SVTSDFQVLTCHLIIKGNETQSVLKEATYVLKEKFHVEHVTIQVEIDGEFHHDETTCKV

Sequences:

>Translated_299_residues
MGHSHDHGHSKNKKALLIAFLLTTSFMIAEVVGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKR
VEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDL
LGSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNIPIVKEVHDLHIW
SVTSDFQVLTCHLIIKGNETQSVLKEATYVLKEKFHVEHVTIQVEIDGEFHHDETTCKV
>Mature_298_residues
GHSHDHGHSKNKKALLIAFLLTTSFMIAEVVGGFVTNSLALLSDAGHMLSDAVSLALSLLAFKLGEKTATTAKTYGYKRV
EMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGMLIIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLL
GSVGAIIAALLIKFFGWTAADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNIPIVKEVHDLHIWS
VTSDFQVLTCHLIIKGNETQSVLKEATYVLKEKFHVEHVTIQVEIDGEFHHDETTCKV

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21361112, Length=310, Percent_Identity=33.5483870967742, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI52352805, Length=305, Percent_Identity=33.1147540983607, Blast_Score=168, Evalue=5e-42,
Organism=Homo sapiens, GI21359890, Length=305, Percent_Identity=35.0819672131148, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI289803013, Length=282, Percent_Identity=33.6879432624113, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI289803009, Length=282, Percent_Identity=33.6879432624113, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI289803007, Length=282, Percent_Identity=33.6879432624113, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI289803003, Length=282, Percent_Identity=33.6879432624113, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI64762489, Length=316, Percent_Identity=32.5949367088608, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI20070323, Length=325, Percent_Identity=27.6923076923077, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI14210520, Length=230, Percent_Identity=32.6086956521739, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI52351208, Length=132, Percent_Identity=40.1515151515151, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=41.9354838709677, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI222080086, Length=127, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=127, Percent_Identity=29.9212598425197, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=47.4820143884892, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI1790349, Length=218, Percent_Identity=22.4770642201835, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555794, Length=318, Percent_Identity=36.4779874213836, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17555796, Length=314, Percent_Identity=35.6687898089172, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI193210990, Length=326, Percent_Identity=33.4355828220859, Blast_Score=174, Evalue=7e-44,
Organism=Caenorhabditis elegans, GI32564488, Length=296, Percent_Identity=30.0675675675676, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320411, Length=180, Percent_Identity=39.4444444444444, Blast_Score=105, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6323899, Length=132, Percent_Identity=40.1515151515151, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324892, Length=113, Percent_Identity=39.8230088495575, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583858, Length=312, Percent_Identity=31.4102564102564, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24656728, Length=339, Percent_Identity=30.6784660766962, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656724, Length=339, Percent_Identity=30.6784660766962, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656720, Length=339, Percent_Identity=30.6784660766962, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24656715, Length=339, Percent_Identity=30.6784660766962, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357035, Length=339, Percent_Identity=30.6784660766962, Blast_Score=117, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24585900, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585898, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585896, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19921672, Length=150, Percent_Identity=38, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24584409, Length=142, Percent_Identity=33.0985915492958, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574430, Length=142, Percent_Identity=33.0985915492958, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645863, Length=125, Percent_Identity=36, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 32648; Mature: 32517

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHSHDHGHSKNKKALLIAFLLTTSFMIAEVVGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATTAKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGML
HHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNIPIVKEVHDLHIW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHEEEE
SVTSDFQVLTCHLIIKGNETQSVLKEATYVLKEKFHVEHVTIQVEIDGEFHHDETTCKV
EECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
GHSHDHGHSKNKKALLIAFLLTTSFMIAEVVGGFVTNSLALLSDAGHMLSDAVSLALSL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAFKLGEKTATTAKTYGYKRVEMLAALCNGVVLIVISVYIFIEAIRRFKEPVEIASNGML
HHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
IIAVLGLLINILSAWILMRGGDVKGNLNLRSAFLHVLGDLLGSVGAIIAALLIKFFGWTA
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADAIASILVSILVIISGWRVTRDTVHILMEGAPQHINVEEVKSTLLNIPIVKEVHDLHIW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHEEEE
SVTSDFQVLTCHLIIKGNETQSVLKEATYVLKEKFHVEHVTIQVEIDGEFHHDETTCKV
EECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA