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The map label for this gene is maP1 [H]

Identifier: 218234368

GI number: 218234368

Start: 137792

End: 138538

Strand: Direct

Name: maP1 [H]

Synonym: BCB4264_A0153

Alternate gene names: 218234368

Gene position: 137792-138538 (Clockwise)

Preceding gene: 218230934

Following gene: 218235846

Centisome position: 2.54

GC content: 43.37

Gene sequence:

>747_bases
ATGATAATCTGCAAAACTCCTCGCGAGATAGAAATCATGCGAGAAGCTGGCAGGATCGTTGCTTTGACTCATCAAGAGTT
GAAACAGCACATTACTCCAGGAATTACAACGAAAGAGCTCGATCAAATAGCGGAAAAGACGATTCAAAAATATGGTGCTA
CGCCATCTTTTAAAGGATACAACGGATTTCCGGGGAGCATATGTGCTTCTGTAAATGAAGAGCTTGTACACGGAATTCCA
GGGAAGCGCAAGCTCAAAGAGGGCGATATCATCAGTATCGATATTGGTGCGAAATACAATGGGTACCATGGAGATTCTGC
ATGGACGTATCCAGTTGGAAACATTTCTGAATCTGTTCAAAAGCTACTTGATGTCACAGAAAAATCGTTGTATCTTGGTC
TAGAACAAGTAAAACCAGGCGAGAGATTATCAAATATCTCACATGCGGTTCAAACCCATGCTGAAGAGAATGGATTCTCG
ATCGTTAGGGAGTATGTTGGTCACGGAATCGGGCAAGACTTACATGAGGCCCCTCAAATCCCGCACTATGGTCCACCAAA
TAGAGGCCCTAGATTAAAGCCGGGAATGGTCATCTGTGTTGAGCCGATGGTGAATCAAGGAAGACGATATGTAAAAACAC
TATCTGATGACTGGACAGTGGTAACGGTAGATGGTAAATGGTGTGCCCATTTTGAGCACACGATTGCTCTTACAGAAGCA
GGATACGAAATCCTTACCACTTTATAA

Upstream 100 bases:

>100_bases
ATTTCTACGAAGAGCTTGGTTACTTACAAAGCATTAATGGTGAGCAAGATATCAATAAAGTATTTGCTGATATCGATGTT
CTCATCGGAGGCTTAGCGTA

Downstream 100 bases:

>100_bases
GTAGCTGGCTCTCCGGGATTTCAGAGCAGTGTAAAATGTTACTGATTTGAAGAAGGGAGAACTATTGAATGGCTAAAGAT
GATGTAATTGAAGTCGAAGG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP 1; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEAPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL

Sequences:

>Translated_248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEAPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL
>Mature_248_residues
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGYNGFPGSICASVNEELVHGIP
GKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQKLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFS
IVREYVGHGIGQDLHEAPQIPHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
GYEILTTL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=238, Percent_Identity=42.0168067226891, Blast_Score=193, Evalue=1e-49,
Organism=Homo sapiens, GI40385867, Length=214, Percent_Identity=40.6542056074766, Blast_Score=176, Evalue=1e-44,
Organism=Escherichia coli, GI1786364, Length=244, Percent_Identity=44.672131147541, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1789275, Length=222, Percent_Identity=26.5765765765766, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788728, Length=204, Percent_Identity=25.4901960784314, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996291, Length=242, Percent_Identity=39.6694214876033, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6323273, Length=219, Percent_Identity=47.4885844748858, Blast_Score=201, Evalue=9e-53,
Organism=Drosophila melanogaster, GI21355531, Length=238, Percent_Identity=42.0168067226891, Blast_Score=197, Evalue=7e-51,
Organism=Drosophila melanogaster, GI24583427, Length=243, Percent_Identity=38.6831275720165, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI19920384, Length=231, Percent_Identity=23.3766233766234, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27483; Mature: 27483

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGY
CEEECCCHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGFPGSICASVNEELVHGIPGKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQ
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHH
KLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFSIVREYVGHGIGQDLHEAPQI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCC
PHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
CCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCEEEEEECCCEEEHHHHEEEEHHC
GYEILTTL
CHHHHHCC
>Mature Secondary Structure
MIICKTPREIEIMREAGRIVALTHQELKQHITPGITTKELDQIAEKTIQKYGATPSFKGY
CEEECCCHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
NGFPGSICASVNEELVHGIPGKRKLKEGDIISIDIGAKYNGYHGDSAWTYPVGNISESVQ
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEECCCCCHHHHHH
KLLDVTEKSLYLGLEQVKPGERLSNISHAVQTHAEENGFSIVREYVGHGIGQDLHEAPQI
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHCCCC
PHYGPPNRGPRLKPGMVICVEPMVNQGRRYVKTLSDDWTVVTVDGKWCAHFEHTIALTEA
CCCCCCCCCCCCCCCEEEEECHHHHCCHHHHHHCCCCEEEEEECCCEEEHHHHEEEEHHC
GYEILTTL
CHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113521; 8635744; 9384377 [H]