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The map label for this gene is kynU [H]

Identifier: 218234076

GI number: 218234076

Start: 2669684

End: 2670970

Strand: Reverse

Name: kynU [H]

Synonym: BCB4264_A2766

Alternate gene names: 218234076

Gene position: 2670970-2669684 (Counterclockwise)

Preceding gene: 218233654

Following gene: 218235986

Centisome position: 49.29

GC content: 35.66

Gene sequence:

>1287_bases
ATGTATAAAGAACCATTTCAACCAACTTATGAGTATGCGCTTGAATGTGATAAACATGATGAACTGAAAGATTTTCAAAC
TGAATTCTATAAAAAAGAAGGTACTATATATTTAGATGGAAACTCATTAGGGCTACTTTCAAAAAGAGCAGAGAAATCAT
TACTTACGTTGCTAGATTCGTGGAAAGAGTATGGCATTGACGGCTGGACAGAAGGTGAGCACCCGTGGTTTTTCCTTTCA
GAGAAATTAGGTAAACTTACAGCCCCTCTTATTGGTGCTTTACCGGAAGAAACTATTGTAACCGGTTCTACAACTACAAA
TATACACCAAGTTATTGCGACGTTTTACGAACCAAAAGGAATACGTACAAAAATACTTGCGGATGAATTAACTTTCCCAT
CAGATATTTATGCACTTCAAAGTCAAATTCGTTTAAAAGGATTAGATCCAGAGGAGCATTTAGTAAGAGTGAAAAGCCGA
GATGGTAGAACACTTTCTGAAGAAGATATTATCCATGCGATGGAAGATGATATCGCTTTAATTTTATTACCTTCTGTTTT
ATATAGAAGTGGTCAAATTCTTGATATGAAACGTTTAACAACGGAAGCTCATAAACGCGGCATTCACATTGGATTTGATT
TATGCCATTCAATAGGATCTATTCCGCATCATTTCAAAGATTGGGATGTCGATTTTGCTGTTTGGTGCAATTATAAATAT
TTAAATGCAGGACCGGGTAGTGTTGCAGGCCTTTATGTAAATAGTAAACATTTTAATAGACTGCCAGGATTGTCTGGATG
GTTTAGTTCTAGAAAAGATAAACAGTTTGATATGGAGCATACATTAACAGCTGCTGATCATGCAGGTGCTTATCAAATTG
GTACACCGCACGTATTAAGTACAGCACCATTAATTGGTTCACTTGAAATTTTCAAAGATGCTGGTATTGAACGTTTACGT
GAGAAATCTTTACATATTACGAGATACATGCTGAATTTAATTGGACATGAATTAAAAGATTTCGAATTTACAATTGGAAA
TCCATTAGAGGATGAAAAACGAGGCGGGCACATTTATTTAGAGCATGCAGAAGCAGCACGTATATGTAAAGCACTAAAAG
CAAATGGAGTAATTCCAGATTTTAGAGCGCCAAATGGGGTGAGACTTGCGCCGGTCGCTTTATATAACACATACGAAGAA
GTGTGGAAATCTGTACAAATATTAAAGAAAATTATGAAAAATGAAGAGTATAAGCAGTTTGAAAATAAGCGAGAGGTTGT
GGCATAA

Upstream 100 bases:

>100_bases
TATATAAAGTCAACTGACATAATATCATTGACGTTGTATCAATTAAGGTGATATATTTCAATTAGTTAGAATAAAAAGAA
AATTAAGAGAAGGTGACACC

Downstream 100 bases:

>100_bases
ATATGAAAACATTAGAGTGGATTGATATTTCACAACCGCTAAATAATAATATTGCAACGTGGCCAGGAGACACACCGTTC
TCGTATGAAGTTTCATGGTC

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSR
DGRTLSEEDIIHAMEDDIALILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKY
LNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWKSVQILKKIMKNEEYKQFENKREVVA

Sequences:

>Translated_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSR
DGRTLSEEDIIHAMEDDIALILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKY
LNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWKSVQILKKIMKNEEYKQFENKREVVA
>Mature_428_residues
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDSWKEYGIDGWTEGEHPWFFLS
EKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKGIRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSR
DGRTLSEEDIIHAMEDDIALILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKY
LNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLSTAPLIGSLEIFKDAGIERLR
EKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYLEHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEE
VWKSVQILKKIMKNEEYKQFENKREVVA

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=443, Percent_Identity=35.8916478555305, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI74101437, Length=285, Percent_Identity=36.8421052631579, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17550466, Length=391, Percent_Identity=35.8056265984655, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6323261, Length=449, Percent_Identity=35.6347438752784, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48754; Mature: 48754

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSRDGRTLSEEDIIHAMEDDIAL
CEEEEEHHHCCCCHHHHHHHHHHHCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHCCEEE
ILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKY
EEHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCCCCCCCCCEEEEEEEEE
LNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEECHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWKSVQILKKIMKNEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ENKREVVA
HHHHHCCC
>Mature Secondary Structure
MYKEPFQPTYEYALECDKHDELKDFQTEFYKKEGTIYLDGNSLGLLSKRAEKSLLTLLDS
CCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHH
WKEYGIDGWTEGEHPWFFLSEKLGKLTAPLIGALPEETIVTGSTTTNIHQVIATFYEPKG
HHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCC
IRTKILADELTFPSDIYALQSQIRLKGLDPEEHLVRVKSRDGRTLSEEDIIHAMEDDIAL
CEEEEEHHHCCCCHHHHHHHHHHHCCCCCHHHHHEEEECCCCCCCCHHHHHHHHHCCEEE
ILLPSVLYRSGQILDMKRLTTEAHKRGIHIGFDLCHSIGSIPHHFKDWDVDFAVWCNYKY
EEHHHHHHCCCCEEHHHHHHHHHHHCCCEEHHHHHHHHCCCCCCCCCCCCCEEEEEEEEE
LNAGPGSVAGLYVNSKHFNRLPGLSGWFSSRKDKQFDMEHTLTAADHAGAYQIGTPHVLS
EECCCCCEEEEEEECHHHHCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCCEECCCCCHHC
TAPLIGSLEIFKDAGIERLREKSLHITRYMLNLIGHELKDFEFTIGNPLEDEKRGGHIYL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEE
EHAEAARICKALKANGVIPDFRAPNGVRLAPVALYNTYEEVWKSVQILKKIMKNEEYKQF
ECHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ENKREVVA
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA