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The map label for this gene is pyrC [H]

Identifier: 218233994

GI number: 218233994

Start: 3911008

End: 3912294

Strand: Reverse

Name: pyrC [H]

Synonym: BCB4264_A3986

Alternate gene names: 218233994

Gene position: 3912294-3911008 (Counterclockwise)

Preceding gene: 218234413

Following gene: 218233547

Centisome position: 72.2

GC content: 40.64

Gene sequence:

>1287_bases
ATGAATTATTTGTTTAAAAATGGTCGTTATATGAATGAAGAAGGAAAAATCGTAGCAACGGATCTTCTCGTACAAGACGG
TAAAATCGCTAAGGTAGCAGAAAATATTACGGCAGATAATGCTGAAGTAATCGATGTGAACGGAAAGTTAATCGCACCTG
GATTAGTAGATGTACACGTACATCTTCGTGAACCAGGTGGTGAACATAAAGAAACAATTGAAACAGGTACACTAGCAGCG
GCAAAAGGTGGATTCACTACAATTTGCGCAATGCCAAATACACGCCCGGTACCAGATTGCAGAGAACATATGGAAGACTT
GCAAAAACGTATTGAAGAAAAAGCTCATGTTAACGTACTACCATACGGAGCAATTACAGTACGTCAAGCTGGTTCTGAAA
TGACAGATTTCGAAACATTAAAAGAACTTGGAGCATTTGCTTTCACAGATGACGGCGTAGGCGTACAAGATGCGAACATG
ATGTTAGCGGCTATGAAACGTGCAGCAAAATTAGATATGGCAGTAGTTGCGCACTGTGAAGAGAATACGCTTATTAATAA
AGGTTGTGTACATGAAGGGAAGTTTTCTGAGAAACACGGATTAAACGGTATCCCATCAGTATGTGAATCTGTACATATTG
CAAGGGATATACTGCTTGCTGAAGCAGCAGATTGCCACTATCACGTATGTCATGTAAGTACGAAAGGTTCTGTACGTGTA
ATCCGTGATGCGAAACGCGCTGGAATTAAAGTAACAGCAGAAGTAACACCGCATCACCTAGTGTTATGTGAAGATGATAT
CCCATCAGCTGATCCTAACTTTAAAATGAACCCACCGCTTCGTGGAAAAGAAGACCATGCAGCATTAATTGAAGGTTTAT
TAGATGGAACGATCGATATGATCGCAACTGACCATGCACCGCATACAGCGGAAGAGAAAGCACAAGGAATTGAAAGAGCA
CCGTTTGGAATTACTGGTTTTGAAACAGCATTCCCGCTTCTATACACAAACCTTGTGAAAAAGGGAGTTATTACGCTAGA
ACAGTTAATTCAATTCTTAACAGAAAAGCCAGCTGATACATTCGGCTTAGAAGCAGGTCGCCTAAAAGAAGGTAGAGCAG
CTGATATTACAATCATTGATTTAGAACAAGAAGAAGAGATTGACCCAACAACATTCTTATCAAAAGGAAAAAATACACCA
TTCGCAGGTTGGAAATGCCAAGGATGGCCGGTAATGACAATCGTTGGTGGTAAGATCGCATGGCAAAAGGAGAGTGCATT
AGTATGA

Upstream 100 bases:

>100_bases
TGTGAGCGTTCACGTATATTTAAACAAATGGAAAATGGAGTTTACGTAAGAATGGCTGTACTAAAACGCGCCTTACCAAA
TGTATTAGGAGGAATGAAAC

Downstream 100 bases:

>100_bases
AAAGACAACTTATCTTAGAAGATGGAACAGTATTAATTGGAACAGGTTTCGGAGGCGAAATCGAAAAGTCAGGTGAGGTT
GTATTTACAACAGGAATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDANM
MLAAMKRAAKLDMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADTFGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV

Sequences:

>Translated_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDANM
MLAAMKRAAKLDMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADTFGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV
>Mature_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDANM
MLAAMKRAAKLDMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADTFGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTP
FAGWKCQGWPVMTIVGGKIAWQKESALV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=32.7319587628866, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=25.2212389380531, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=24.3243243243243, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI62422571, Length=444, Percent_Identity=24.3243243243243, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI19923821, Length=446, Percent_Identity=26.2331838565022, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786722, Length=445, Percent_Identity=29.8876404494382, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI87082175, Length=435, Percent_Identity=28.735632183908, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193204318, Length=359, Percent_Identity=33.1476323119777, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539558, Length=448, Percent_Identity=26.5625, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI86575075, Length=446, Percent_Identity=25.3363228699552, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=26.1467889908257, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=32.5520833333333, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=26.3922518159806, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46598; Mature: 46598

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDANMMLAAMKRAAKLDMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCEEHEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC
>Mature Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQKRIEEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDANMMLAAMKRAAKLDMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHCCEEHEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGVITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRAADITIIDLEQEEEIDPTTFLSKGKNTPFAGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA