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The map label for this gene is ina [H]

Identifier: 218233608

GI number: 218233608

Start: 1291690

End: 1294080

Strand: Direct

Name: ina [H]

Synonym: BCB4264_A1335

Alternate gene names: 218233608

Gene position: 1291690-1294080 (Clockwise)

Preceding gene: 218235686

Following gene: 218233378

Centisome position: 23.84

GC content: 39.4

Gene sequence:

>2391_bases
ATGAACAAGAAACCGTTCAAAGTTTTGTCATCAATCGCTTTGACAGCTGTATTAGGCCTTTCATTTGGAGCTGGCACTCA
ATCTGCATATGCTGAAACGCCTGCGAATAAAACAGCTACGAGCCCAGTTGATGATCATTTAATTCCGGAAGAGCGTTTAG
CAGATGCGCTAAAAAAACGTGGGGTAATTGATTCGAAGGCTTCAGAGACAGAAACAAAGAAAGCAGTCGAAAAGTATGTA
GAGAACAAAAAGGGTGAAAATCCTGGAAAAGAAGCAGCGAATGGGGACCAACTTACGAAAGATGCATCTGACTTTTTAAA
GAAAGTGAAAGATGCGAAAGCAGACACGAAAGAAAAATTAAATCAACCAGCAACAGGCACACCTGCAGCGACAGGTCCAG
TTAAAGGCGGTCTAAATGGTAAAGTACCAACTTCTCCAGCGAAACAAAAAGACTATAACGGTGAAGTTCGTAAAGATAAA
GTACTCGTTTTACTTGTAGAGTACGCTGACTTTAAGCATAATAATATCGACAAAGAGCCTGGATATATGTATTCTAACGA
TTTTAATAAAGAACATTATGAAAAAATGTTATTCGGCAACGAGCCATTCACATTAGATGATGGAAGTAAAATTGAAACGT
TTAAACAATATTACGAAGAGCAATCTGGTGGTAGTTACACAGTGGACGGAACAGTTACAAAATGGTTAACAGTTCCTGGT
AAAGCTGCTGATTACGGTGCAGATGCTGCTAGCGGCGGTCATGATAATAAAGGACCAAAAGGGCCACGTGATTTAGTAAA
AGATGCATTAAAAGCAGCTGTAGATAGTGGTATTGATTTATCAGAGTTCGACCAATTTGATCAATATGATGTAAATGGTG
ATGGAAATAAAAATCAACCAGACGGTTTAATCGATCACTTAATGATTATTCATGCGGGTGTTGGACAAGAAGCAGGCGGT
GGTAAATTAGGGGATGATGCAATTTGGTCGCACCGTTGGACAGTTGGACCAAAGCCATTCCCAATTGAAGGTACACAAGC
GAAAGTACCATATTGGGGTGGAAAGATGGCAGCATTCGACTACACAATTGAACCAGAAGATGGAGCAGTTGGTGTATTCG
CACATGAATATGGTCATGATTTAGGTCTTCCAGATGAGTACGATACACAATATAGTGGTCAAGGTGAGCCGATTGAAGCT
TGGTCTATTATGAGTGGCGGAAGCTGGGCTGGTAAAATCGCTGGAACGACGCCAACGAGTTTCTCACCACAAAATAAAGA
GTTTTTCCAGAAAACAATCGGTGGTAACTGGGCAAATATCGTAGAAGTAGATTACGAGAAATTAAATAAAGGTATCGGTC
TAGCGACATATTTGGATCAAAGTGTTACGAAATCAGCAAGACCAGGTATGATCCGTGTTAACTTACCAGATAAAGATGTT
AAAACAATTGAGCCAGCATTTGGTAAACAATATTATTACAGCACAAAAGGTGACGATCTTCATACGAAGATGGAAACACC
GTTGTTCGATTTAACGAATGCAACGAATGCAAAATTTGATTTCAAGTCATTATATGAGATTGAAGCAGGTTATGATTTTC
TTGAAGTACACGCTGTAACAGAAGATGGTCAACAAACGTTAATTGAAAGACTTGGTGAGAAAGCAAATAGTGGAAATGCA
GATTCGACAAATGGAAAATGGATTGACAAATCATATGATTTAAGTCAATTCAAAGGCAAGAAAGTAAAATTAACATTTGA
TTACATTACTGATGGTGGTTTAGCATTAAATGGATTCGCTCTTGATAATGCTTCATTAACAGTAGATGGTAAAGTGGTAT
TCTCTGATGACGCAGAAGGTACACCACAATTAAAATTAGATGGTTTCGCTGTTTCTAACGGAACAGAGAAGAAAAGCCAT
AACTACTATGTTGAGTGGAGAAACTATGCTGGGGCAGATAACGCGTTGAAATTTGCTCGCGGTCCAGTATTTAACACTGG
TATGGTTGTATGGTATGCAGATTCAGCTTATACAGATAACTGGGTTGGTGTACATCCAGGACACGGTTTCCTTGGTGTAG
TTGATTCTCATCCAGAAGCAATTGTAGGTACTTTAAATGGTAAACCGACAGTTAAGAGTAGTACACGATTCCAAATCGCT
GATGCAGCGTTCTCATTCGACAAAACGCCAGCTTGGAAAGTCGTATCTCCAACGCGTGGAACATTTACGTATGATGGCTT
AGCAGGTGTACCGAAGTTTGATGATTCTAAAACGTATATTAATCAACAGATTCCAGATGCAGGACGTATTTTACCGAAGC
TTGGTCTGAAGTTTGAAGTAGTAGGACAAGCTGATGATAATTCTGCAGGTGCTGTTCGTTTATATCGTTAA

Upstream 100 bases:

>100_bases
TAAAAAAATTACAGAATGTGACTAAATATTGAAAAAATATTGAATTTTTAATAAAATTCAATTTGTAATACATATTAGTT
ATTAGGGGAGGAAATATGGG

Downstream 100 bases:

>100_bases
TACTGTAAAACTACCGAGAGATTTTCTTTCGGTAGTTTTTTTGTGAGCAATGAATTTTATATAGCTGAAAAAGTCATATA
TAATGTAACCTTAAGAATAA

Product: immune inhibitor A metalloprotease InhA1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 796; Mature: 796

Protein sequence:

>796_residues
MNKKPFKVLSSIALTAVLGLSFGAGTQSAYAETPANKTATSPVDDHLIPEERLADALKKRGVIDSKASETETKKAVEKYV
ENKKGENPGKEAANGDQLTKDASDFLKKVKDAKADTKEKLNQPATGTPAATGPVKGGLNGKVPTSPAKQKDYNGEVRKDK
VLVLLVEYADFKHNNIDKEPGYMYSNDFNKEHYEKMLFGNEPFTLDDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPG
KAADYGADAASGGHDNKGPKGPRDLVKDALKAAVDSGIDLSEFDQFDQYDVNGDGNKNQPDGLIDHLMIIHAGVGQEAGG
GKLGDDAIWSHRWTVGPKPFPIEGTQAKVPYWGGKMAAFDYTIEPEDGAVGVFAHEYGHDLGLPDEYDTQYSGQGEPIEA
WSIMSGGSWAGKIAGTTPTSFSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSARPGMIRVNLPDKDV
KTIEPAFGKQYYYSTKGDDLHTKMETPLFDLTNATNAKFDFKSLYEIEAGYDFLEVHAVTEDGQQTLIERLGEKANSGNA
DSTNGKWIDKSYDLSQFKGKKVKLTFDYITDGGLALNGFALDNASLTVDGKVVFSDDAEGTPQLKLDGFAVSNGTEKKSH
NYYVEWRNYAGADNALKFARGPVFNTGMVVWYADSAYTDNWVGVHPGHGFLGVVDSHPEAIVGTLNGKPTVKSSTRFQIA
DAAFSFDKTPAWKVVSPTRGTFTYDGLAGVPKFDDSKTYINQQIPDAGRILPKLGLKFEVVGQADDNSAGAVRLYR

Sequences:

>Translated_796_residues
MNKKPFKVLSSIALTAVLGLSFGAGTQSAYAETPANKTATSPVDDHLIPEERLADALKKRGVIDSKASETETKKAVEKYV
ENKKGENPGKEAANGDQLTKDASDFLKKVKDAKADTKEKLNQPATGTPAATGPVKGGLNGKVPTSPAKQKDYNGEVRKDK
VLVLLVEYADFKHNNIDKEPGYMYSNDFNKEHYEKMLFGNEPFTLDDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPG
KAADYGADAASGGHDNKGPKGPRDLVKDALKAAVDSGIDLSEFDQFDQYDVNGDGNKNQPDGLIDHLMIIHAGVGQEAGG
GKLGDDAIWSHRWTVGPKPFPIEGTQAKVPYWGGKMAAFDYTIEPEDGAVGVFAHEYGHDLGLPDEYDTQYSGQGEPIEA
WSIMSGGSWAGKIAGTTPTSFSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSARPGMIRVNLPDKDV
KTIEPAFGKQYYYSTKGDDLHTKMETPLFDLTNATNAKFDFKSLYEIEAGYDFLEVHAVTEDGQQTLIERLGEKANSGNA
DSTNGKWIDKSYDLSQFKGKKVKLTFDYITDGGLALNGFALDNASLTVDGKVVFSDDAEGTPQLKLDGFAVSNGTEKKSH
NYYVEWRNYAGADNALKFARGPVFNTGMVVWYADSAYTDNWVGVHPGHGFLGVVDSHPEAIVGTLNGKPTVKSSTRFQIA
DAAFSFDKTPAWKVVSPTRGTFTYDGLAGVPKFDDSKTYINQQIPDAGRILPKLGLKFEVVGQADDNSAGAVRLYR
>Mature_796_residues
MNKKPFKVLSSIALTAVLGLSFGAGTQSAYAETPANKTATSPVDDHLIPEERLADALKKRGVIDSKASETETKKAVEKYV
ENKKGENPGKEAANGDQLTKDASDFLKKVKDAKADTKEKLNQPATGTPAATGPVKGGLNGKVPTSPAKQKDYNGEVRKDK
VLVLLVEYADFKHNNIDKEPGYMYSNDFNKEHYEKMLFGNEPFTLDDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPG
KAADYGADAASGGHDNKGPKGPRDLVKDALKAAVDSGIDLSEFDQFDQYDVNGDGNKNQPDGLIDHLMIIHAGVGQEAGG
GKLGDDAIWSHRWTVGPKPFPIEGTQAKVPYWGGKMAAFDYTIEPEDGAVGVFAHEYGHDLGLPDEYDTQYSGQGEPIEA
WSIMSGGSWAGKIAGTTPTSFSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSARPGMIRVNLPDKDV
KTIEPAFGKQYYYSTKGDDLHTKMETPLFDLTNATNAKFDFKSLYEIEAGYDFLEVHAVTEDGQQTLIERLGEKANSGNA
DSTNGKWIDKSYDLSQFKGKKVKLTFDYITDGGLALNGFALDNASLTVDGKVVFSDDAEGTPQLKLDGFAVSNGTEKKSH
NYYVEWRNYAGADNALKFARGPVFNTGMVVWYADSAYTDNWVGVHPGHGFLGVVDSHPEAIVGTLNGKPTVKSSTRFQIA
DAAFSFDKTPAWKVVSPTRGTFTYDGLAGVPKFDDSKTYINQQIPDAGRILPKLGLKFEVVGQADDNSAGAVRLYR

Specific function: Neutral metalloprotease that is secreted to degrade antibacterial proteins produced by the insect host for its defense (attacins and cecropins). Probably degrades some unknown crucial protein(s) too, since it is toxic when injected to insect larvae [H]

COG id: COG4412

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M6 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012300
- InterPro:   IPR008757 [H]

Pfam domain/function: PF05547 Peptidase_M6 [H]

EC number: NA

Molecular weight: Translated: 86543; Mature: 86543

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKPFKVLSSIALTAVLGLSFGAGTQSAYAETPANKTATSPVDDHLIPEERLADALKKR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GVIDSKASETETKKAVEKYVENKKGENPGKEAANGDQLTKDASDFLKKVKDAKADTKEKL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
NQPATGTPAATGPVKGGLNGKVPTSPAKQKDYNGEVRKDKVLVLLVEYADFKHNNIDKEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCC
GYMYSNDFNKEHYEKMLFGNEPFTLDDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPG
CEEECCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHCCCCCEEECCCEEEEEECCC
KAADYGADAASGGHDNKGPKGPRDLVKDALKAAVDSGIDLSEFDQFDQYDVNGDGNKNQP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCC
DGLIDHLMIIHAGVGQEAGGGKLGDDAIWSHRWTVGPKPFPIEGTQAKVPYWGGKMAAFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCEECCCCCCCCCCCCCEECCCCCCEEEEEE
YTIEPEDGAVGVFAHEYGHDLGLPDEYDTQYSGQGEPIEAWSIMSGGSWAGKIAGTTPTS
EEECCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEECCCCCCC
FSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSARPGMIRVNLPDKDV
CCCCCHHHHHHHHCCCEEEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCH
KTIEPAFGKQYYYSTKGDDLHTKMETPLFDLTNATNAKFDFKSLYEIEAGYDFLEVHAVT
HHCCCCCCCEEEEECCCCCCHHHHCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
EDGQQTLIERLGEKANSGNADSTNGKWIDKSYDLSQFKGKKVKLTFDYITDGGLALNGFA
CCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHCCCEEEEEEEEECCCCEEEEEEE
LDNASLTVDGKVVFSDDAEGTPQLKLDGFAVSNGTEKKSHNYYVEWRNYAGADNALKFAR
ECCCEEEECCEEEECCCCCCCCCEEECCEEECCCCCCCCCCEEEEECCCCCCCHHHHHHC
GPVFNTGMVVWYADSAYTDNWVGVHPGHGFLGVVDSHPEAIVGTLNGKPTVKSSTRFQIA
CCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCEEEEE
DAAFSFDKTPAWKVVSPTRGTFTYDGLAGVPKFDDSKTYINQQIPDAGRILPKLGLKFEV
HHHHCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCEEEE
VGQADDNSAGAVRLYR
EECCCCCCCCEEEEEC
>Mature Secondary Structure
MNKKPFKVLSSIALTAVLGLSFGAGTQSAYAETPANKTATSPVDDHLIPEERLADALKKR
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GVIDSKASETETKKAVEKYVENKKGENPGKEAANGDQLTKDASDFLKKVKDAKADTKEKL
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
NQPATGTPAATGPVKGGLNGKVPTSPAKQKDYNGEVRKDKVLVLLVEYADFKHNNIDKEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCC
GYMYSNDFNKEHYEKMLFGNEPFTLDDGSKIETFKQYYEEQSGGSYTVDGTVTKWLTVPG
CEEECCCCCHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHCCCCCEEECCCEEEEEECCC
KAADYGADAASGGHDNKGPKGPRDLVKDALKAAVDSGIDLSEFDQFDQYDVNGDGNKNQP
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCC
DGLIDHLMIIHAGVGQEAGGGKLGDDAIWSHRWTVGPKPFPIEGTQAKVPYWGGKMAAFD
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCEECCCCCCCCCCCCCEECCCCCCEEEEEE
YTIEPEDGAVGVFAHEYGHDLGLPDEYDTQYSGQGEPIEAWSIMSGGSWAGKIAGTTPTS
EEECCCCCEEEEEEHHCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEECCCCCCC
FSPQNKEFFQKTIGGNWANIVEVDYEKLNKGIGLATYLDQSVTKSARPGMIRVNLPDKDV
CCCCCHHHHHHHHCCCEEEEEEECHHHHHCCCCHHHHHHHHHHHCCCCCEEEEECCCCCH
KTIEPAFGKQYYYSTKGDDLHTKMETPLFDLTNATNAKFDFKSLYEIEAGYDFLEVHAVT
HHCCCCCCCEEEEECCCCCCHHHHCCCEEECCCCCCCCCCHHHHHHHHCCCCEEEEEEEC
EDGQQTLIERLGEKANSGNADSTNGKWIDKSYDLSQFKGKKVKLTFDYITDGGLALNGFA
CCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCHHHHCCCEEEEEEEEECCCCEEEEEEE
LDNASLTVDGKVVFSDDAEGTPQLKLDGFAVSNGTEKKSHNYYVEWRNYAGADNALKFAR
ECCCEEEECCEEEECCCCCCCCCEEECCEEECCCCCCCCCCEEEEECCCCCCCHHHHHHC
GPVFNTGMVVWYADSAYTDNWVGVHPGHGFLGVVDSHPEAIVGTLNGKPTVKSSTRFQIA
CCCCCCCEEEEEECCCCCCCEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCEEEEE
DAAFSFDKTPAWKVVSPTRGTFTYDGLAGVPKFDDSKTYINQQIPDAGRILPKLGLKFEV
HHHHCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCEEEE
VGQADDNSAGAVRLYR
EECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2089225; 6421577 [H]