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The map label for this gene is cdr [H]

Identifier: 218233479

GI number: 218233479

Start: 800655

End: 802319

Strand: Direct

Name: cdr [H]

Synonym: BCB4264_A0828

Alternate gene names: 218233479

Gene position: 800655-802319 (Clockwise)

Preceding gene: 218231708

Following gene: 218232890

Centisome position: 14.77

GC content: 37.84

Gene sequence:

>1665_bases
ATGTTTAGAAAAATTGTTGTAGTAGGCGGAGTTGCTGGCGGGGCATCAGTAGCTGCAAGGCTTCGTCGTTTAAGTGAGGA
AGATGAAATTATTATGGTTGAACGCGGTGAATACATTTCGTTCGCAAACTGTGGATTGCCATATTATATTGGCGGTGTCA
TTACAGAAAGACAAAAGTTATTAGTACAAACTGTTGAAAGGATGTCAAAACGTTTTAATTTAGATATACGTGTATTGAGT
GAAGTTGTAAAGATTAATAAAGAAGAGAAAACAATTACGATAAAGAATGTAACTACAGATGAAACATATAACGAGGAATA
TGATGTTTTGATTCTTTCACCAGGGGCGAAACCAATTGTTCCACCTATTCCGGGCATTGAAGAAGCGAAGGCGTTGTTTA
CGTTACGAAATGTACCTGATACTGATCGTATAAAAGCGTATATTGATGAGAAGAAACCACGTTATGCGACGGTTATTGGT
GGAGGATTTATTGGAGTGGAAATGGTTGAGAATTTAAGAGAACGCGGGATTGAGGTTACTCTTGTAGAGATGGCAAATCA
AGTGATGCCACCAATTGATTACGAAATGGCGGCATATGTACATGAGCATATGAAGGTGCACAATGTTGAGCTTGTTTTTG
AAGATGGTGTAGATGCGTTAGAAGAGAATGGGACTGTTGTACGTTTAAAAAGTGGCTCAGTTATAAAAACAGATATGATT
ATTTTAGCAATTGGTGTACAACCAGAGAGTAGTTTAGCGAAAGATGCAGGATTATCATTAGGAGTTAGAGGAACGATAAA
GGTAAATGAGAAATTTCAAACATCTGACCCATATGTATATGCAATTGGTGATGCGATTGAAGTGAAAGATTTTGTTACAG
AAACAGAAACGATGATTCCTTTAGCGTGGCCCGCTAATCGTCAAGGTCGTATGTTAGCAGATATTATTCATGGCCATACG
GAGTCTTTATATAAAGGTACGATGGGAACTTCTGTGGCTAAAGTTTTTGATTTAACAGTTGCTTCGACTGGAGTAAATGA
GAAAATATTAAAACGATTAAATATACCCTATGAGGTAGTACATGTACAGGCAAATTCTCATGCAGGATACTATCCGAATG
CTACGCCAGTGCTAATAAAATTAATTTTTAATAAAGATAGCGGAAAGATTTACGGAACACAGGCTTTAGGGCGTGACGGG
GTAGATAAGCGTATAGATGTTATCGCGACGGCAATGAAGGCAAACTTAGCTGTAATCGATTTACCAGATTTAGAATTATC
ATATGCCCCGCCGTATTCTTCTGCAAAAGATCCAGTAAACATGGTGGGGTATGCCGCAAGTAATATAGTAGATGGTTTTG
TGGAAACGGTACAATGGCATGAAATAGATCGTATTGTTGACAATGGTGGATATCTTATAGATGTTCGGGAGCCCAATGAA
CTAAAACAAGGAATGATTAAAGGCTCTATTAATATTCCGTTAGATGAATTACGTGATCGATTGGATGAAGTGCCAATGGA
CAAAGAAATATATATCACTTGTCAACTTGGTATGAGAGGGTATGTTGCAGCGCGCATGTTAATGGAAAAAGGATATAAGG
TAAAGAATGTAGATGGTGGTTTTAAATTGTATGGGACAGTACTGCCAGAACGTGTTGTATATTGA

Upstream 100 bases:

>100_bases
TGATTGAAAATAAATTTTTTATACTCTATCATATACCCATACAGGTATAGGTTTTTCTGTGTGATGCATGAGAAAATTAA
ATAATATGGAGGTTCGAAAT

Downstream 100 bases:

>100_bases
TATTTTTCATCTTCTACTTCAAGATTTAGTGGAAGATAAAAACTTATAGATTAAGGTTTTATTTTTTGTTTTGCGAACAT
ATAAGGTGAAAATTTAAAAT

Product: pyridine nucleotide-disulfide oxidoreductase, class I

Products: NA

Alternate protein names: CoA-disulfide reductase; CoADR [H]

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MFRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVKINKEEKTITIKNVTTDETYNEEYDVLILSPGAKPIVPPIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRYATVIG
GGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKVHNVELVFEDGVDALEENGTVVRLKSGSVIKTDMI
ILAIGVQPESSLAKDAGLSLGVRGTIKVNEKFQTSDPYVYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
ESLYKGTMGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGTQALGRDG
VDKRIDVIATAMKANLAVIDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVETVQWHEIDRIVDNGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPMDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERVVY

Sequences:

>Translated_554_residues
MFRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVKINKEEKTITIKNVTTDETYNEEYDVLILSPGAKPIVPPIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRYATVIG
GGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKVHNVELVFEDGVDALEENGTVVRLKSGSVIKTDMI
ILAIGVQPESSLAKDAGLSLGVRGTIKVNEKFQTSDPYVYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
ESLYKGTMGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGTQALGRDG
VDKRIDVIATAMKANLAVIDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVETVQWHEIDRIVDNGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPMDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERVVY
>Mature_554_residues
MFRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKLLVQTVERMSKRFNLDIRVLS
EVVKINKEEKTITIKNVTTDETYNEEYDVLILSPGAKPIVPPIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRYATVIG
GGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKVHNVELVFEDGVDALEENGTVVRLKSGSVIKTDMI
ILAIGVQPESSLAKDAGLSLGVRGTIKVNEKFQTSDPYVYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHT
ESLYKGTMGTSVAKVFDLTVASTGVNEKILKRLNIPYEVVHVQANSHAGYYPNATPVLIKLIFNKDSGKIYGTQALGRDG
VDKRIDVIATAMKANLAVIDLPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVETVQWHEIDRIVDNGGYLIDVREPNE
LKQGMIKGSINIPLDELRDRLDEVPMDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGGFKLYGTVLPERVVY

Specific function: Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI21389617, Length=308, Percent_Identity=25.974025974026, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI65787454, Length=308, Percent_Identity=25.974025974026, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI226437568, Length=308, Percent_Identity=25.974025974026, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI1789065, Length=283, Percent_Identity=27.9151943462898, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87082354, Length=294, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1789765, Length=289, Percent_Identity=26.9896193771626, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786307, Length=308, Percent_Identity=26.9480519480519, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788892, Length=195, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17559934, Length=218, Percent_Identity=24.7706422018349, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585130, Length=300, Percent_Identity=24.6666666666667, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017758
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.14 [H]

Molecular weight: Translated: 61439; Mature: 61439

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50206 RHODANESE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVKINKEEKTITIKNVTTDETYNEEYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCC
PPIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRYATVIGGGFIGVEMVENLRERGIEVT
CCCCCHHHHHHHEEECCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
LVEMANQVMPPIDYEMAAYVHEHMKVHNVELVFEDGVDALEENGTVVRLKSGSVIKTDMI
EEHHHHHHCCCCCHHHHHHHHHHHEEEEEEEEEECCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKDAGLSLGVRGTIKVNEKFQTSDPYVYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCCEECEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGHTESLYKGTMGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCHHHHHHHCCHHHHHCCCCCCHHHHHHEEEEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGTQALGRDGVDKRIDVIATAMKANLAVID
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVETVQWHEIDRIVDNGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPMDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERVVY
EEEEEECCCHHHCC
>Mature Secondary Structure
MFRKIVVVGGVAGGASVAARLRRLSEEDEIIMVERGEYISFANCGLPYYIGGVITERQKL
CCEEEEEEECCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
LVQTVERMSKRFNLDIRVLSEVVKINKEEKTITIKNVTTDETYNEEYDVLILSPGAKPIV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCC
PPIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRYATVIGGGFIGVEMVENLRERGIEVT
CCCCCHHHHHHHEEECCCCCHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCEEE
LVEMANQVMPPIDYEMAAYVHEHMKVHNVELVFEDGVDALEENGTVVRLKSGSVIKTDMI
EEHHHHHHCCCCCHHHHHHHHHHHEEEEEEEEEECCCHHHHCCCCEEEECCCCEEEEEEE
ILAIGVQPESSLAKDAGLSLGVRGTIKVNEKFQTSDPYVYAIGDAIEVKDFVTETETMIP
EEEEECCCCHHHHHHCCCEECEEEEEEECCCCCCCCCEEEEECCCEEHHHHHCCCCCEEE
LAWPANRQGRMLADIIHGHTESLYKGTMGTSVAKVFDLTVASTGVNEKILKRLNIPYEVV
EECCCCCCCCHHHHHHHCCHHHHHCCCCCCHHHHHHEEEEECCCCCHHHHHHHCCCEEEE
HVQANSHAGYYPNATPVLIKLIFNKDSGKIYGTQALGRDGVDKRIDVIATAMKANLAVID
EEEECCCCCCCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHCCEEEEE
LPDLELSYAPPYSSAKDPVNMVGYAASNIVDGFVETVQWHEIDRIVDNGGYLIDVREPNE
CCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHH
LKQGMIKGSINIPLDELRDRLDEVPMDKEIYITCQLGMRGYVAARMLMEKGYKVKNVDGG
HHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCEEEECCCC
FKLYGTVLPERVVY
EEEEEECCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA