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The map label for this gene is thlA [H]

Identifier: 218233417

GI number: 218233417

Start: 4041294

End: 4042469

Strand: Reverse

Name: thlA [H]

Synonym: BCB4264_A4129

Alternate gene names: 218233417

Gene position: 4042469-4041294 (Counterclockwise)

Preceding gene: 218232803

Following gene: 218235916

Centisome position: 74.6

GC content: 41.24

Gene sequence:

>1176_bases
ATGCATAATGTTGTTATTACAGCTGCAGTTCGTTCGCCAATTGGAACTTTTGGAGGAGCGCTAAAAAATGTAACGCCAGT
AGAATTAGCTGTTCCTGTACTTCAGGAAGCTGTAAAACGAGGCGGGGTAGAACCACATGAAGTTGATGAAGTAATTTTAG
GTCATTGTATTCAAAGAACTGATGAAGCAAATACGGCGAGAACAGCTGCATTAGCGGCAGGATTTCCTGACACAGTTACG
GGATATACAATCCAACGTCAATGTTCTTCAGGTATGCAAGCAATTATGTCAGCTGCAATGCAAATCCAATTAGGTGTAAG
TGATGTTGTTGTTGCAGGTGGGGTAGAAGCGATGAGTTCGAGCCCTTATGCATTGAAACAGCACCGCTGGGGACAACGTC
TACAGCACGGAGAAATTCGTGATACGGTGTGGGAAGTGTTAGAAGATCCGATTCACCATATTATGATGGGTGAAACAGCG
GAAAATTTAGTTGAACAATATGAAATTACAAGAGAGGAACAAGATGAAGTTGCTCTTCGCAGTCATACATTGGCACTGAA
GGCAATCGAGTCTGGATACTTTGACGATCAAATTGTTCCTATTACAATAAAAGAGCGTAGAAAAGAAGTTGTATTTTCGA
AGGATGAACATCCACGTGCAGATATTACAGCTGAAAAATTAGCTGGATTGAAGCCGGCATTCCGTAAAGATGGATCAGTG
ACTGCTGGAAATGCATCTGGCCTTAATGACGGGAGTGCAGTTCTAGTATTAATGAGCGAAGAAAAAGCGAAAGAAAAAGG
TTTACAACCGTTAGCTAGAATTGTTGGATATTCAGTAGCTGGAGTAGATCCAAAAATTATGGGTATTGGACCAGCACCAG
CAATTCGTAAAGGTTTAGAAAAAGTAGATTGGTTATTGGAAGATGCAGATTTACTTGAAATTAATGAAGCTTTCGCGGCT
CAATATTTAGCTGTAGAGAAAGAGTTAGGCTTAGACCGTGAAAAAGTGAACGTAAACGGTAGTGGCGTAGGACTTGGGCA
TCCAATTGGTTGTACAGGGGCTCGTATTACAGTAAGTTTAATTCACGAATTAAAAAGACGTGGGTTAGAAAAAGGAATTG
CCTCTTTATGCGTCGGTGGCGGTATCGGGGTTGCCTTATTTATAGAAGCACTATAA

Upstream 100 bases:

>100_bases
GATTTTTTAGTATGTTTATAGTATGATAGTTATAGATATACATCTTATGGAATTTCACCTAAAAACTGACTAGGGTACAT
AAGAGAGGGGCAAGTGCAAA

Downstream 100 bases:

>100_bases
AAAAGAAGCAGCTATTGCTGCTTCTTTTTTTACGACTCAAATAGATGATGGAATAATCGATCGCGATTTTCAAAGAAAAG
TTTCGTCGTTTGGTAATGCT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWLLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Sequences:

>Translated_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWLLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL
>Mature_391_residues
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRTDEANTARTAALAAGFPDTVT
GYTIQRQCSSGMQAIMSAAMQIQLGVSDVVVAGGVEAMSSSPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETA
ENLVEQYEITREEQDEVALRSHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLEKVDWLLEDADLLEINEAFAA
QYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSLIHELKRRGLEKGIASLCVGGGIGVALFIEAL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=43.8775510204082, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.2159383033419, Blast_Score=335, Evalue=3e-92,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=40.8629441624365, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4557237, Length=397, Percent_Identity=40.0503778337531, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=35.0467289719626, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=29.0488431876607, Blast_Score=145, Evalue=5e-35,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=49.1094147582697, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI87082165, Length=394, Percent_Identity=46.9543147208122, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=42.643391521197, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI48994986, Length=404, Percent_Identity=39.1089108910891, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1788683, Length=401, Percent_Identity=30.4239401496259, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=49.4845360824742, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25147385, Length=389, Percent_Identity=37.2750642673522, Blast_Score=252, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.2151898734177, Blast_Score=235, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=31.924882629108, Blast_Score=205, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=29.8469387755102, Blast_Score=159, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=38.8059701492537, Blast_Score=252, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6322031, Length=401, Percent_Identity=38.6533665835411, Blast_Score=240, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.9387755102041, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=44.5012787723785, Blast_Score=315, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=41.7302798982188, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=35.377358490566, Blast_Score=211, Evalue=8e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41897; Mature: 41897

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSDVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWLLEDADLLEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC
>Mature Secondary Structure
MHNVVITAAVRSPIGTFGGALKNVTPVELAVPVLQEAVKRGGVEPHEVDEVILGHCIQRT
CCCEEEEHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
DEANTARTAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSDVVVAGGVEAMSS
CCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEECCHHHHCC
SPYALKQHRWGQRLQHGEIRDTVWEVLEDPIHHIMMGETAENLVEQYEITREEQDEVALR
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
SHTLALKAIESGYFDDQIVPITIKERRKEVVFSKDEHPRADITAEKLAGLKPAFRKDGSV
HHHHHHHHHHCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCE
TAGNASGLNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIMGIGPAPAIRKGLE
ECCCCCCCCCCCEEEEEECCHHHHHHCHHHHHHHHCCHHCCCCCEEEECCCCHHHHHHHH
KVDWLLEDADLLEINEAFAAQYLAVEKELGLDREKVNVNGSGVGLGHPIGCTGARITVSL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCCCCCCCHHHHHHH
IHELKRRGLEKGIASLCVGGGIGVALFIEAL
HHHHHHHHHHHHHHHHHHCCCCEEHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]