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The map label for this gene is alsR [H]

Identifier: 218233214

GI number: 218233214

Start: 3688411

End: 3689310

Strand: Reverse

Name: alsR [H]

Synonym: BCB4264_A3776

Alternate gene names: 218233214

Gene position: 3689310-3688411 (Counterclockwise)

Preceding gene: 218234638

Following gene: 218233383

Centisome position: 68.08

GC content: 35.22

Gene sequence:

>900_bases
ATGGAATTACGGCATTTGCAATATTTTGTTGTTGTGGCAGAAGAGTTACACTTTGGACGGGCAGCTGCTCGTTTACAAAT
GACACAACCACCACTTAGTCAACAAATACAGCAATTAGAAAAAGAAATGGGAGTTACATTATTTTCAAGAACGAAAAGAA
AGGTTGAACTAACAGAAGCAGGAGAAATGTTTTTAAAAGAAGTAAAAAAAGCGTTTGAACAAATTGAAAAAGCAGTAGAA
GTTGCACAAAGTGCGCAAAGGGGAGAAGTAGGATCACTTTCAATTGGTTTTGTAGGTGCGGCGATATATGATATTTTACC
ATCAATTGTTAGGGAATATAGAAAGAAATTTCCGAGAGTGTCTGTTGCATTACATGAATTGTCAACACCAGATCAAGTTC
ATGCACTTCATGATAACCGTATCGATATTGGCTTTTTACGTCCACCAATTCCAACACAATTATTAGAATTAGAGCCAATT
CAAAGGTTATCTTGCACCTTATGTTTACCAAAGGCACATCCACTTGCAGAGAAAGATGAAATACATATAGAAGATTTACG
AGATGAGCCGTTTGTATTTATTACGAGACCAGTATGGCCAGCTTTGTATGATACAATTTTATCTCTTTGCAGAGAAGTTG
GATTTAGTCCACGTATTGTACAAGAAGCAACAGAGTATCAAACAGTTATGGGGCTTGTAGCAGCAGGGATTGGAATTACA
GTAATACCCGTATCGGCAAATAAGTTATATAAAACAGAAGTTGTATATAAAGAATTATATGATTCTAATTTTGTGGCAGA
AATGTCAGTGGCTTACAAAAAAATGAATAGTAATCCAGAGCTACTAGAGTTTTTAAAAATTGCAAGAGAGAAGAAAAGAA
TAGAAGTAGAAGATGAGTAA

Upstream 100 bases:

>100_bases
ATTTCTACTATACGTTCATTCAAAATATTTGTCTAATATATAAATTATATGTTATTAATATATTAGACATATTAATCGAA
AGTGAAAAGGGTGTCCAAAA

Downstream 100 bases:

>100_bases
TAGTAGTAACAGAAAATGGAGTTAATTCAGATTTATAAAAGTACACCTTGTTAAACAATAAAGCGGAAATGCAACTTAAG
TTGCATTTCCGCTTTATTGT

Product: transcriptional regulator, LysR family

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVTLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
VAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QRLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDE

Sequences:

>Translated_299_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVTLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
VAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QRLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDE
>Mature_299_residues
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVTLFSRTKRKVELTEAGEMFLKEVKKAFEQIEKAVE
VAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRVSVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPI
QRLSCTLCLPKAHPLAEKDEIHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDE

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=275, Percent_Identity=38.9090909090909, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI2367136, Length=286, Percent_Identity=33.5664335664336, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1788887, Length=297, Percent_Identity=36.7003367003367, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=29.3388429752066, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1790399, Length=248, Percent_Identity=31.4516129032258, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI145693105, Length=245, Percent_Identity=24.8979591836735, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787530, Length=251, Percent_Identity=29.4820717131474, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789204, Length=251, Percent_Identity=27.0916334661355, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788748, Length=264, Percent_Identity=26.8939393939394, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081904, Length=184, Percent_Identity=31.5217391304348, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788297, Length=256, Percent_Identity=26.5625, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1790208, Length=298, Percent_Identity=26.510067114094, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787806, Length=248, Percent_Identity=23.7903225806452, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=26.3374485596708, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787589, Length=123, Percent_Identity=38.2113821138211, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789506, Length=242, Percent_Identity=25.2066115702479, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=197, Percent_Identity=26.9035532994924, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1787601, Length=143, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789639, Length=249, Percent_Identity=24.0963855421687, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1787949, Length=302, Percent_Identity=23.841059602649, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=257, Percent_Identity=25.2918287937743, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=155, Percent_Identity=24.5161290322581, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787128, Length=144, Percent_Identity=27.0833333333333, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34077; Mature: 34077

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVTLFSRTKRKVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCEEEHHHH
GEMFLKEVKKAFEQIEKAVEVAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHH
SVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPIQRLSCTLCLPKAHPLAEKDE
HHHHHHCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHHHHEEECCCCCCCCCCCC
IHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
EEHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELRHLQYFVVVAEELHFGRAAARLQMTQPPLSQQIQQLEKEMGVTLFSRTKRKVELTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHCCCEEEHHHH
GEMFLKEVKKAFEQIEKAVEVAQSAQRGEVGSLSIGFVGAAIYDILPSIVREYRKKFPRV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCHH
SVALHELSTPDQVHALHDNRIDIGFLRPPIPTQLLELEPIQRLSCTLCLPKAHPLAEKDE
HHHHHHCCCCHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHHHHEEECCCCCCCCCCCC
IHIEDLRDEPFVFITRPVWPALYDTILSLCREVGFSPRIVQEATEYQTVMGLVAAGIGIT
EEHCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEE
VIPVSANKLYKTEVVYKELYDSNFVAEMSVAYKKMNSNPELLEFLKIAREKKRIEVEDE
EEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]