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The map label for this gene is rocD [H]

Identifier: 218233198

GI number: 218233198

Start: 1170549

End: 1171739

Strand: Reverse

Name: rocD [H]

Synonym: BCB4264_A1204

Alternate gene names: 218233198

Gene position: 1171739-1170549 (Counterclockwise)

Preceding gene: 218235391

Following gene: 218232585

Centisome position: 21.62

GC content: 39.97

Gene sequence:

>1191_bases
ATGATTCAAACTAAGGATATTATCGAACTTACAGACACATACGGAGCAAATAACTATCACCCACTTCCAATCGTTATTTC
TAAAGCAGAAGGTGTTTGGGTAGAAGATCCTGAAGGAAACCGCTATATGGACTTATTAAGTGCATATTCTGCAGTAAACC
AAGGTCATCGTCACCCGAAAATTATTAACGCTTTAATTGACCAAGCTAATCGTGTTACGTTAACTTCTCGTGCTTTCCAT
AGCGATCAATTAGGTCCTTGGTACGAAAAAGTTGCGAAACTAACTAATAAAGAAATGGTACTTCCAATGAATACAGGTGC
TGAAGCTGTTGAAACTGCAATTAAAACAGTTCGTCGCTGGGCTTATGATGTGAAGAAAGTAGAAGCAAACCGCGCTGAAA
TCATCGTTTGTGAAGATAACTTCCACGGACGTACAATGGGTTCTGTTTCTATGTCTTCAAACGAAGAGTACAAGCGTGGA
TTCGGTCCAATGCTTCCTGGCATCGTTGTAATTCCTTACGGTGATTTAGAAGCGTTAAAAGCTGCAATTACACCAAACAC
AGCTGCATTCATTTTAGAGCCAATTCAAGGTGAAGCAGGAATTAACATCCCACCAGCTGGTTACTTAAAAGAAGCTTTTG
AAGTATGTAAAAAAGAAAACGTTTTATTTGTAGCAGATGAAATCCAAACTGGCTTAGGCCGCACTGGTAAAGTATTTGCT
TGTGACTGGGACAATGTAACTCCTGACATGTACATACTTGGTAAAGCACTTGGCGGCGGCGTATTCCCGATCTCTTGTGT
TGCAGCAAACCGCGATATTTTAGGTGTATTTGAGCCAGGTTCTCACGGTTCTACATTCGGTGGTAACCCACTTGCATGTG
CTGTTTCTATCGCAGCTCTTGAAGTGTTAGAAGAAGAAAAATTAACAGAGCGTTCTCTTCAATTAGGAGAAAAATTAGTT
GGGCAATTAAAAGAGATTGACAACCCAATGATCACTGAAGTTCGCGGTAAAGGTTTATTCATCGGTATCGAATTAAACGA
GCCAGCTCGTCCTTACTGTGAACAACTAAAAGCAGCTGGTCTACTATGTAAAGAAACACATGAAAACGTAATTCGTATCG
CACCACCTCTAGTAATCTCTGAAGAAGATTTAGAGTGGGCATTCCAAAAAATTAAAGCTGTATTATCGTAA

Upstream 100 bases:

>100_bases
GTTCATTTATTTTCAGGAAATGTTTCGCTTTTTTACATTTAAATGCTATAATATTTAGAGTATTTACAAACTTCTTGTAA
TAACAAAAGGGGGAACAATC

Downstream 100 bases:

>100_bases
TGATAGGGAGGTTGTCCGACATGTTGGGACAACCTCTTTCTTTTTATATTCATTTATATTAAGATAAAATTTTAATTTTC
TGTATTTTAAAATCGTAAAG

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFH
SDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTVRRWAYDVKKVEANRAEIIVCEDNFHGRTMGSVSMSSNEEYKRG
FGPMLPGIVVIPYGDLEALKAAITPNTAAFILEPIQGEAGINIPPAGYLKEAFEVCKKENVLFVADEIQTGLGRTGKVFA
CDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLV
GQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAGLLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS

Sequences:

>Translated_396_residues
MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFH
SDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTVRRWAYDVKKVEANRAEIIVCEDNFHGRTMGSVSMSSNEEYKRG
FGPMLPGIVVIPYGDLEALKAAITPNTAAFILEPIQGEAGINIPPAGYLKEAFEVCKKENVLFVADEIQTGLGRTGKVFA
CDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLV
GQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAGLLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS
>Mature_396_residues
MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPKIINALIDQANRVTLTSRAFH
SDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTVRRWAYDVKKVEANRAEIIVCEDNFHGRTMGSVSMSSNEEYKRG
FGPMLPGIVVIPYGDLEALKAAITPNTAAFILEPIQGEAGINIPPAGYLKEAFEVCKKENVLFVADEIQTGLGRTGKVFA
CDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAALEVLEEEKLTERSLQLGEKLV
GQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAGLLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=399, Percent_Identity=50.6265664160401, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI284507298, Length=300, Percent_Identity=50, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI13994255, Length=435, Percent_Identity=28.9655172413793, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=28.7769784172662, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI37574042, Length=419, Percent_Identity=27.6849642004773, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI226442705, Length=419, Percent_Identity=26.9689737470167, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=27.6485788113695, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=35.8839050131926, Blast_Score=241, Evalue=5e-65,
Organism=Escherichia coli, GI145693181, Length=378, Percent_Identity=34.1269841269841, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1788044, Length=381, Percent_Identity=33.5958005249344, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=32.4324324324324, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789016, Length=406, Percent_Identity=30.0492610837438, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1786991, Length=359, Percent_Identity=31.4763231197772, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786349, Length=356, Percent_Identity=28.0898876404494, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=389, Percent_Identity=49.8714652956298, Blast_Score=401, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25144274, Length=266, Percent_Identity=48.4962406015038, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI32564660, Length=431, Percent_Identity=32.4825986078886, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71981843, Length=176, Percent_Identity=47.1590909090909, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=430, Percent_Identity=27.906976744186, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17541228, Length=426, Percent_Identity=23.7089201877934, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=50.4854368932039, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324432, Length=382, Percent_Identity=31.413612565445, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=25, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321456, Length=405, Percent_Identity=23.4567901234568, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357415, Length=389, Percent_Identity=51.9280205655527, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI161085790, Length=427, Percent_Identity=29.9765807962529, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI28574759, Length=422, Percent_Identity=30.3317535545024, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=27.511961722488, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI281366494, Length=427, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=427, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=427, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43380; Mature: 43380

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPK
CCCCCCHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IINALIDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTVRRW
HHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
AYDVKKVEANRAEIIVCEDNFHGRTMGSVSMSSNEEYKRGFGPMLPGIVVIPYGDLEALK
HHHHHHHCCCCEEEEEECCCCCCCEECEEECCCCHHHHHCCCCCCCCEEEEECCCHHHHH
AAITPNTAAFILEPIQGEAGINIPPAGYLKEAFEVCKKENVLFVADEIQTGLGRTGKVFA
HHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEE
CDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAAL
ECCCCCCCCCEEEEHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
EVLEEEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHCC
LLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS
CHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MIQTKDIIELTDTYGANNYHPLPIVISKAEGVWVEDPEGNRYMDLLSAYSAVNQGHRHPK
CCCCCCHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IINALIDQANRVTLTSRAFHSDQLGPWYEKVAKLTNKEMVLPMNTGAEAVETAIKTVRRW
HHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
AYDVKKVEANRAEIIVCEDNFHGRTMGSVSMSSNEEYKRGFGPMLPGIVVIPYGDLEALK
HHHHHHHCCCCEEEEEECCCCCCCEECEEECCCCHHHHHCCCCCCCCEEEEECCCHHHHH
AAITPNTAAFILEPIQGEAGINIPPAGYLKEAFEVCKKENVLFVADEIQTGLGRTGKVFA
HHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCEEE
CDWDNVTPDMYILGKALGGGVFPISCVAANRDILGVFEPGSHGSTFGGNPLACAVSIAAL
ECCCCCCCCCEEEEHHHCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
EVLEEEKLTERSLQLGEKLVGQLKEIDNPMITEVRGKGLFIGIELNEPARPYCEQLKAAG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEECCCCCHHHHHHHHCC
LLCKETHENVIRIAPPLVISEEDLEWAFQKIKAVLS
CHHHHHHCCEEEECCCEEECCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA