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The map label for this gene is cysG [H]

Identifier: 218233141

GI number: 218233141

Start: 1418658

End: 1419434

Strand: Direct

Name: cysG [H]

Synonym: BCB4264_A1481

Alternate gene names: 218233141

Gene position: 1418658-1419434 (Clockwise)

Preceding gene: 218230793

Following gene: 218230762

Centisome position: 26.18

GC content: 41.18

Gene sequence:

>777_bases
ATGGGAAAGGTTTATATTGTTGGAGCGGGTCCTGGCGATCCAGATTTAATTACTGTTAAAGGGTTGAAATGTATTGAGAA
GGCAGATGTTATTTTATATGACCGACTTGTGAATAAAGAGCTGCTTTCACACGCAAAGCCTGACGCGGATTTAATTTATT
GCGGAAAACTCCCGAATTATCACACGATGAAGCAAGAGACAATTAACACGTTTCTTATTAAGTATGCGAAAAAAGGAAAA
GTTGTAACGAGACTTAAGGGCGGCGATCCATTTGTGTTTGGTAGAGGGGGAGAAGAAGCTGAAGCATTAGCAAAGCAAGG
TGTACCATTTGAAATCATTCCTGGTATTTCAGCTGGAATAGCTGCTCCTGCTTATGCGGGCATTCCAGTGACGCACCGTG
ATGCAAGTGCAAGTTTTGCTATTGTGACTGGGCATAGGAAAGAAGGTGCTGAAGAAGAAGTGAAATGGGAGAGTTTAGCG
AAAGGTGTAGAGACTTTAGCGGTATATATGGGGGTTAGTAATTTGCCCTACATATGTGAGCAACTTATGAAGCATGGAAA
AGATAAAAGTACGCCAGCTGCTATTATTGAGCAGGGGACGACGTCTATGCAACGCACAGTTGTTGGAACGTTAGGGACAA
TTGTAGATGTTGCGAAAAAAGAGCAAATTCAAAATCCGAGTATGATTGTAATTGGAGAGGTTGTCCGTTTTAGAGAAAAA
ATTCATTGGTTTGAGAAGCAGACAGAAAATGCTTATCAAGTAAGTGGAGTGTTGTAA

Upstream 100 bases:

>100_bases
TGTTATCCATGAGTAGAGATCAGTAATACGAAAAAATAAAAACTTCCATTCTTATATACGAATGGAAGTTTCATTTTAAT
AGAAGAAATGAGGAGAGATG

Downstream 100 bases:

>100_bases
AATGAAAGCCGTCTTATATATATGTCATGGAAGTCGTTTGAAGACAGCGAAAGAAGAGGCGATTCAATTTATTACATCGT
GCATGAGCCGTATAGAAGCG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSHAKPDADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
VVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIIPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEGAEEEVKWESLA
KGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIEQGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
IHWFEKQTENAYQVSGVL

Sequences:

>Translated_258_residues
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSHAKPDADLIYCGKLPNYHTMKQETINTFLIKYAKKGK
VVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIIPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEGAEEEVKWESLA
KGVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIEQGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
IHWFEKQTENAYQVSGVL
>Mature_257_residues
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSHAKPDADLIYCGKLPNYHTMKQETINTFLIKYAKKGKV
VTRLKGGDPFVFGRGGEEAEALAKQGVPFEIIPGISAGIAAPAYAGIPVTHRDASASFAIVTGHRKEGAEEEVKWESLAK
GVETLAVYMGVSNLPYICEQLMKHGKDKSTPAAIIEQGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREKI
HWFEKQTENAYQVSGVL

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=246, Percent_Identity=47.5609756097561, Blast_Score=249, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6322922, Length=237, Percent_Identity=32.4894514767932, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 28056; Mature: 27925

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSHAKPDADLIYCGKLPNY
CCEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKVVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIIPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEGAEEEVKWESLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLMKHGKDKSTPAAIIEQGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTENAYQVSGVL
HHHHHHHCCCCEEEECCC
>Mature Secondary Structure 
GKVYIVGAGPGDPDLITVKGLKCIEKADVILYDRLVNKELLSHAKPDADLIYCGKLPNY
CEEEEEECCCCCCCEEEECCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCC
HTMKQETINTFLIKYAKKGKVVTRLKGGDPFVFGRGGEEAEALAKQGVPFEIIPGISAGI
CHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEECCCCCHHHHHHHCCCCEEEECCCCCCC
AAPAYAGIPVTHRDASASFAIVTGHRKEGAEEEVKWESLAKGVETLAVYMGVSNLPYICE
CCCCCCCCCEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
QLMKHGKDKSTPAAIIEQGTTSMQRTVVGTLGTIVDVAKKEQIQNPSMIVIGEVVRFREK
HHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHH
IHWFEKQTENAYQVSGVL
HHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]