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The map label for this gene is fmt [H]

Identifier: 218233113

GI number: 218233113

Start: 3887239

End: 3888183

Strand: Reverse

Name: fmt [H]

Synonym: BCB4264_A3965

Alternate gene names: 218233113

Gene position: 3888183-3887239 (Counterclockwise)

Preceding gene: 218232337

Following gene: 218233863

Centisome position: 71.75

GC content: 37.57

Gene sequence:

>945_bases
ATGATAAAAGTAGTGTTTATGGGAACACCGGACTTTTCAGTGCCGGTGCTTCGTCGTCTTATTGAAGATGGCTATGAGGT
AGTAGGTGTTGTGACGCAACCTGATCGTCCAGTAGGTAGAAAAAAAGTATTAACACCTACACCTGTTAAAGTTGAAGCGG
AAAAACATGGTATCCCTGTGTTACAGCCGTTAAAAATTCGTGAAAAAGATGAATATGAAAAAGTATTGGCATTAGAGCCA
GATTTAATTGTAACAGCTGCATTTGGGCAGATTGTACCAAATGAAATTTTAGAAGCACCAAAGTATGGGTGTATTAATGT
TCACGCTTCTTTACTTCCTGAACTTCGTGGTGGTGCACCAATTCATTATGCAATTATGGAAGGTAAAGAAAAAACAGGTA
TTACAATTATGTATATGGTAGAAAAATTGGATGCTGGTGATATCTTAACGCAAGTGGAAGTTGAAATTGAAGAGCGTGAA
ACGACAGGCTCATTATTTGATAAATTAAGTGAAGCAGGAGCACACCTTCTATCTAAAACAGTGCCTTTATTAATTCAAGG
TAAGTTAGAACCGATTAAACAAAACGAAGAAGAAGTAACGTTTGCGTACAATATAAAACGTGAGCAAGAGAAAATTGATT
GGACAAAAACAGGTGAAGAAGTATACAATCACATTCGCGGATTGAATCCATGGCCAGTTGCTTATACAACTTTAGCAGGA
CAAGTTGTTAAAGTATGGTGGGGGGAAAAAGTGCCTATAACTGAACCGGCTGAAGCAGGTACGATTGTTGCAATCGAAGA
AGATGGTTTTGTTGTAGCAACGAGTAATGAAACAGGTGTTAAAATTACTGAATTGCAACCTTCTGGTAAAAAGCGTATGA
GTTGTTCACAATTTTTACGTGGAACAAAACCTGAAATTGGAACGAAGTTAGGAGAAAATGCATGA

Upstream 100 bases:

>100_bases
ATGAAATTGATCATTTACACGGTGTTTTATTTACATCGAAAGTGACAAGATATTATGAAGAAAACGAACTAGAATAGGTG
TTAAAAGGAGCGGTTTTTAA

Downstream 100 bases:

>100_bases
GACAAAATGTTCGTGAATTAGCTCTTGATGGTTTAATTCAAGTGGAAAAAAGTGGTGCATATAGCAACTTACTTTTAAAT
AATCTAATTGAAAAAAGTGC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYEVVGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLKIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPITEPAEAGTIVAIEEDGFVVATSNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA

Sequences:

>Translated_314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYEVVGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLKIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPITEPAEAGTIVAIEEDGFVVATSNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA
>Mature_314_residues
MIKVVFMGTPDFSVPVLRRLIEDGYEVVGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPVLQPLKIREKDEYEKVLALEP
DLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAPIHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERE
TTGSLFDKLSEAGAHLLSKTVPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
QVVKVWWGEKVPITEPAEAGTIVAIEEDGFVVATSNETGVKITELQPSGKKRMSCSQFLRGTKPEIGTKLGENA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI21614513, Length=322, Percent_Identity=29.5031055900621, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI238814322, Length=311, Percent_Identity=29.5819935691318, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI164663775, Length=236, Percent_Identity=30.0847457627119, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789683, Length=302, Percent_Identity=41.7218543046358, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1788589, Length=265, Percent_Identity=29.0566037735849, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=270, Percent_Identity=34.8148148148148, Blast_Score=133, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319458, Length=278, Percent_Identity=26.2589928057554, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI45550868, Length=306, Percent_Identity=32.0261437908497, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28571984, Length=281, Percent_Identity=31.6725978647687, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=27.3469387755102, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34764; Mature: 34764

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVVFMGTPDFSVPVLRRLIEDGYEVVGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPV
CEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEHHHCCCCC
LQPLKIREKDEYEKVLALEPDLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAP
CCCCCCCCCCCHHHEEEECCCEEEEEHHHHCCCHHHHCCCCCCEEEEHHHHHHHHCCCCC
IHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERETTGSLFDKLSEAGAHLLSKT
EEEEEECCCCCCCEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
VPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
CCEEEECCCCCCCCCCCEEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHC
QVVKVWWGEKVPITEPAEAGTIVAIEEDGFVVATSNETGVKITELQPSGKKRMSCSQFLR
EEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHC
GTKPEIGTKLGENA
CCCCCHHCCCCCCC
>Mature Secondary Structure
MIKVVFMGTPDFSVPVLRRLIEDGYEVVGVVTQPDRPVGRKKVLTPTPVKVEAEKHGIPV
CEEEEEECCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEHHHCCCCC
LQPLKIREKDEYEKVLALEPDLIVTAAFGQIVPNEILEAPKYGCINVHASLLPELRGGAP
CCCCCCCCCCCHHHEEEECCCEEEEEHHHHCCCHHHHCCCCCCEEEEHHHHHHHHCCCCC
IHYAIMEGKEKTGITIMYMVEKLDAGDILTQVEVEIEERETTGSLFDKLSEAGAHLLSKT
EEEEEECCCCCCCEEEEEEEECCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHC
VPLLIQGKLEPIKQNEEEVTFAYNIKREQEKIDWTKTGEEVYNHIRGLNPWPVAYTTLAG
CCEEEECCCCCCCCCCCEEEEEEEECHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHC
QVVKVWWGEKVPITEPAEAGTIVAIEEDGFVVATSNETGVKITELQPSGKKRMSCSQFLR
EEEEEECCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCEEEEEECCCCCCCCCHHHHHC
GTKPEIGTKLGENA
CCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA