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The map label for this gene is mutS2 [H]

Identifier: 218232809

GI number: 218232809

Start: 3363936

End: 3365837

Strand: Reverse

Name: mutS2 [H]

Synonym: BCB4264_A3486

Alternate gene names: 218232809

Gene position: 3365837-3363936 (Counterclockwise)

Preceding gene: 218233306

Following gene: 218233699

Centisome position: 62.11

GC content: 32.18

Gene sequence:

>1902_bases
ATGAATACGATGACTTTTGAAAAGTTACAATATAACGAATTAAAGGATATAGTGAAATCTTATTGTGTAAGTGGATTAGG
TAAGGAATTATTAAACAAATTAGAGCCGAGTACGAGTATAAAAGTAGTGAGAAATCGGTTGAATGAAACGACAGAAGCAC
GAGCTATATTAGATGCAGAAGGGCATGTTCCTTTCTTCGGCATTTCTAATATTGCTAGTACAATTCAAAAATTAGAAAAA
GGGATGATTTTAGATCCAGAAGAATTAGTAAGTGTTTCAGACTTTTTACGTGGATGTAGAAAGATTAAAAAGTTTATGTT
AGATAAAGAATTTTTTGCACCAGTATTAGCTTCTTATGCAAATTCAATGACTGAATATAAAAGTATTGAAGAGGAAATTA
ACTTTTCAATTAAAGGAAATAGTATTGATGCAGCTGCAAGTAAAGAGTTAAAGCGAATTCGAAATAATATCGATTCTGTA
GATGGGAAAATAAAAGAACGTTTAACGAAGTTTTTAAATAGTAGTGCAAATAAGAAATTCATTCAGGAATTCTTTATTAG
TAAAAAGGATGACCGTTATACGATTCCAATTAAATCTTCCTATAAAAACCAAGTTGCCGGAAGTATTATTGAAGCCTCGG
CAAAAGGTTCTACTGTATTTATAGAACCGCATACGGTTACGAAATTGAATGCAGAACTAGCAGGTTTGAAAGCAGAAGAA
GCGGTTGAAGAATATCAAATTTTAGCGACTTTATCAGGGATGGTATTAGAAAATATTTATAGTATAAAGATTAACATGGA
GCTAATTAGTCAGTATGATATGGTATTTGCGAAAGCGAAGTTTAGTAAATCGATTGATGGAATAGAACCGAAGTTAAATG
ATCATGGCTACATTCATTTAGTGAATTGTAAGCATCCGCTTTTAACAGGGCAAGTTGTACCCTTAAATTTTAAAATTGGT
CAAGAGTATCGTAGTTTAATTATTACAGGGCCGAATGCGGGCGGAAAGACAATTGTGTTAAAAACAATTGGATTGTTAAC
ATTAGCTACAATGTCAGGTCTTCATATTGCAGGAGATAAAGGGACAGAAATCGCTATTTTCGAAAATGTATTTGTAGATA
TTGGTGATAATCAAAGTATCGAAAACGCACTAAGTACATTTTCATCTCATATGAAAAATCTTTCTGAGATTATGAGGATG
TCAAATAATAATACGTTACTTTTATTTGATGAAATAGGGAGCGGTACAGAACCAAATGAAGGTGCAGCACTTGCAATTTC
TATTTTAGAAGAGTTGTACTTTGCGGGATGTATTACCGTTGCGAGTACGCATTACGGAGAAATTAAACGATTCTCAGAAA
TGCATGATGACTTTATGAATGCAGCGATGCAGTTTAATAGTGAAACGTTAGAGCCGCTTTATAAATTAGTTATCGGAAAA
TCAGGAGAAAGTAATGCACTTTGGATTGCGAATAAAATGAACGTAAAAGAACATGTACTGAAAAGGGCGAAAGAGTACAT
GGGAAATAAAGAGTACGCTTTAGAAAAAGTGAATGAAAGTAAAATTAGAAAACCGAAATTCGTACAAGAAAAAAGAGAAT
CTCATTATGAGTACAAAATCGGCGATCGTGTTAATTTATTGGATCATGATGATTTTGGTATCATCTATAAGGAAAAAGAT
AATTTTTATAACGTTGTTGTATATTATAACGGTGAATTCGTTGAAGTAAATGTAAAACGTATTACTTTAGAAGTAGCAGC
GAAGGAGTTATATCCAGAAGGATACGATTTAAATACACTATTTGTTGATTATAAAGAAAGAAAAATGCAACACGATATTG
AGCGCGGATCGAAAAAAGCACTTCGTAAAATTCAAAAAGAAATAAGAAAGAATAGAGGATAA

Upstream 100 bases:

>100_bases
TTTATTGTATAATTATGGAATTTTATATATGACTCATTGGAATCTAATGAGTAGGTATCTTCATTTATGATAAAAATCAA
TCATAGTGAGGAGAAACAAA

Downstream 100 bases:

>100_bases
GTTAAAATGGTAACGATTAGACAAGAACAAAAAAACGATTGTAGAAAAACAGAAGAAGTCGTAAAAGAGGCATTTTCACT
TGAAGAATTTAGTGATAAAA

Product: putative MutS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELLNKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDAAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKFIQEFFISKKDDRYTIPIKSSYKNQVAGSIIEASAKGSTVFIEPHTVTKLNAELAGLKAEE
AVEEYQILATLSGMVLENIYSIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLTGQVVPLNFKIG
QEYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKGTEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEELYFAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVKEHVLKRAKEYMGNKEYALEKVNESKIRKPKFVQEKRESHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFVEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEIRKNRG

Sequences:

>Translated_633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELLNKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDAAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKFIQEFFISKKDDRYTIPIKSSYKNQVAGSIIEASAKGSTVFIEPHTVTKLNAELAGLKAEE
AVEEYQILATLSGMVLENIYSIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLTGQVVPLNFKIG
QEYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKGTEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEELYFAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVKEHVLKRAKEYMGNKEYALEKVNESKIRKPKFVQEKRESHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFVEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEIRKNRG
>Mature_633_residues
MNTMTFEKLQYNELKDIVKSYCVSGLGKELLNKLEPSTSIKVVRNRLNETTEARAILDAEGHVPFFGISNIASTIQKLEK
GMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYANSMTEYKSIEEEINFSIKGNSIDAAASKELKRIRNNIDSV
DGKIKERLTKFLNSSANKKFIQEFFISKKDDRYTIPIKSSYKNQVAGSIIEASAKGSTVFIEPHTVTKLNAELAGLKAEE
AVEEYQILATLSGMVLENIYSIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHLVNCKHPLLTGQVVPLNFKIG
QEYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDKGTEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRM
SNNNTLLLFDEIGSGTEPNEGAALAISILEELYFAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
SGESNALWIANKMNVKEHVLKRAKEYMGNKEYALEKVNESKIRKPKFVQEKRESHYEYKIGDRVNLLDHDDFGIIYKEKD
NFYNVVVYYNGEFVEVNVKRITLEVAAKELYPEGYDLNTLFVDYKERKMQHDIERGSKKALRKIQKEIRKNRG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=298, Percent_Identity=26.8456375838926, Blast_Score=104, Evalue=3e-22,
Organism=Homo sapiens, GI4504191, Length=284, Percent_Identity=25.3521126760563, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI36949366, Length=354, Percent_Identity=24.5762711864407, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI26638666, Length=217, Percent_Identity=29.4930875576037, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI4505253, Length=217, Percent_Identity=29.4930875576037, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI26638664, Length=217, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI262231786, Length=217, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4557761, Length=184, Percent_Identity=28.804347826087, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1789089, Length=272, Percent_Identity=25.7352941176471, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=322, Percent_Identity=25.1552795031056, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=299, Percent_Identity=24.7491638795987, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539736, Length=292, Percent_Identity=21.9178082191781, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=398, Percent_Identity=27.1356783919598, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324482, Length=298, Percent_Identity=26.1744966442953, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=249, Percent_Identity=22.8915662650602, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=322, Percent_Identity=23.6024844720497, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321109, Length=185, Percent_Identity=27.5675675675676, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24584320, Length=266, Percent_Identity=29.6992481203008, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24664545, Length=544, Percent_Identity=22.4264705882353, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 71625; Mature: 71625

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTMTFEKLQYNELKDIVKSYCVSGLGKELLNKLEPSTSIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDAAASKELKRIRNNIDSVDGKIKERLTKFLNSSANKKF
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIIEASAKGSTVFIEPHTVTKLNAELAGLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCEEEEECHHHHCCCHHH
AVEEYQILATLSGMVLENIYSIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHL
HHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLTGQVVPLNFKIGQEYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEEECCC
GTEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEELYFAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVKEHVLKRAKEYMGNKEYALEKVNESKIRKPKFVQEKRESHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCHHHCCCCHHHHHHHHCCCEEEC
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFVEVNVKRITLEVAAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEHHHHHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRKIQKEIRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNTMTFEKLQYNELKDIVKSYCVSGLGKELLNKLEPSTSIKVVRNRLNETTEARAILDAE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHEEEECC
GHVPFFGISNIASTIQKLEKGMILDPEELVSVSDFLRGCRKIKKFMLDKEFFAPVLASYA
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHH
NSMTEYKSIEEEINFSIKGNSIDAAASKELKRIRNNIDSVDGKIKERLTKFLNSSANKKF
HHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
IQEFFISKKDDRYTIPIKSSYKNQVAGSIIEASAKGSTVFIEPHTVTKLNAELAGLKAEE
HHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEECCCEEEEECHHHHCCCHHH
AVEEYQILATLSGMVLENIYSIKINMELISQYDMVFAKAKFSKSIDGIEPKLNDHGYIHL
HHHHHHHHHHHHHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
VNCKHPLLTGQVVPLNFKIGQEYRSLIITGPNAGGKTIVLKTIGLLTLATMSGLHIAGDK
EECCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCEEHHHHHHHHHHHHHCCCEEECCC
GTEIAIFENVFVDIGDNQSIENALSTFSSHMKNLSEIMRMSNNNTLLLFDEIGSGTEPNE
CCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
GAALAISILEELYFAGCITVASTHYGEIKRFSEMHDDFMNAAMQFNSETLEPLYKLVIGK
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
SGESNALWIANKMNVKEHVLKRAKEYMGNKEYALEKVNESKIRKPKFVQEKRESHYEYKI
CCCCCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHCHHHCCCCHHHHHHHHCCCEEEC
GDRVNLLDHDDFGIIYKEKDNFYNVVVYYNGEFVEVNVKRITLEVAAKELYPEGYDLNTL
CCEEEEECCCCCEEEEEECCCEEEEEEEECCEEEEEEEEEEEHHHHHHHHCCCCCCCEEE
FVDYKERKMQHDIERGSKKALRKIQKEIRKNRG
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA