Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 218232507

GI number: 218232507

Start: 3733247

End: 3734641

Strand: Reverse

Name: gabP [H]

Synonym: BCB4264_A3823

Alternate gene names: 218232507

Gene position: 3734641-3733247 (Counterclockwise)

Preceding gene: 218231354

Following gene: 218233121

Centisome position: 68.92

GC content: 35.77

Gene sequence:

>1395_bases
TTGGATAAAAATCTAAAGAAAGACCTCAAAATACGCCACATTACAATGATTTCAATTGGCGGCGTAATAGGGGCTGGTTT
GTTTGTTGGAAGTGGTGCAGTTGTACATTCGGCAGGACCAGGTTCTATCGTTTCATATGCATTAGCAGGACTTCTAGTCA
TTTTCGTCATGAGAATGCTAGGAGAAATGGCAGCTGTTAATCCGACAAGTGGTTCATTTGCAACGTATGCAAGAGAAGCG
ATTGGTCCTTGGGCGGGTTATACAATAGGCTGGTTATACTGGTTTTTTTGGGTAATTGTTATTGCAATAGAAGCCACAGC
AGGTGCTGGTATTATCCAATATTGGATTCCACAAATACCGCTTTGGTTATTAAGTTTAATATTAACAATTTTATTAACGC
TGACGAACGTTTTTTCGGTGAAATCATTTGGAGAGTTTGAATATTGGTTTTCTTTTATTAAAGTAATAAGTATTGTTTTG
TTCCTTTGTCTAGGTCTTGCTGTTATTTTAGGATTTGTTCCAGGAACAGAAGCACCCGGCACTTCGAATTTAATTGGACA
AGGTGGATTTATGCCAAACGGTATAAGTTCGGTCCTGCTTGGAATTACTGTTGTTATATTTTCATTTATGGGATCAGAGA
TTGTAGCAGTAGCCGCAGGTGAATCTGCAGAACCTGTAAAAGCAGTAAAAACAGCAACAAACAGTGTGATTTGGCGTATT
CTTGTATTTTTTATTGGGTCTATAGCGGTAGTTGTTACGCTACTGCCATGGAATTCAGCAAACATATTAAAAAGTCCATT
TGTAGCTGTACTTGAACATATAGGAATACCAGCGGCAGCACAAATTATGAATTTTATCGTTTTAACAGCTGTACTTTCTT
GCTTAAATTCAGGCTTATATACAAATTCAAGAATGCTTTTTTCAATGGCAGAAAGAGGAGATGCTCCAAAGTCATTTTTA
AAATTGAACAGTAGTGGTGTTCCCGTTCGAGCGGTTTTATTTGGAACTTTCTTCGCTTATATTGGAGTTGTGTTTAGTTA
CATTTCTCCAGATAAAGTCTTTTTGTTTTTAGTGAATGCATCTGGCGGGATTGCGTTACTAGTTTATCTCGTTATTGCAG
TTTCGCATTTAAAGATGCGTAAAAAAATGGGGAAAGTAGAACAACAAAATTTGAAAGTGAAAATGTGGCTTTTTCCGTAT
GTAACGTATGTTACAATTGCTGCTATTATAGCAGTTTTAGTTGCGATGTTCGCAATTGATACTTTACGTTCACAAGCATT
TTTAACAATGTTTGTTACTGTTCTTATCATACTTTCTTATTTTATTTTTAATAGAAATAAAAATATCACAGTTTTGCATC
CTAAAAGTAAGAATGAGGAATCTGTTCGATTCTAA

Upstream 100 bases:

>100_bases
TTCAGAATATTTTGATATATTTTAAAGTATAGGACAAAATCTTTCGCACAGTACTCTTACATAAGTTTCAAAATTTAGTT
TGGAAGGGGATGTACAAGAT

Downstream 100 bases:

>100_bases
TTTTCTTATTTTCGAAGAGAGTTACACCCAATCATTGCTATAAAAGAATCATATATAATCATAGAAACAAGTAATTACTA
TTGTCATAGTGAATATAAAC

Product: GABA permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVIFVMRMLGEMAAVNPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPQIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLIGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKSFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKMRKKMGKVEQQNLKVKMWLFPY
VTYVTIAAIIAVLVAMFAIDTLRSQAFLTMFVTVLIILSYFIFNRNKNITVLHPKSKNEESVRF

Sequences:

>Translated_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVIFVMRMLGEMAAVNPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPQIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLIGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKSFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKMRKKMGKVEQQNLKVKMWLFPY
VTYVTIAAIIAVLVAMFAIDTLRSQAFLTMFVTVLIILSYFIFNRNKNITVLHPKSKNEESVRF
>Mature_464_residues
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVIFVMRMLGEMAAVNPTSGSFATYAREA
IGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPQIPLWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVL
FLCLGLAVILGFVPGTEAPGTSNLIGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLYTNSRMLFSMAERGDAPKSFL
KLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNASGGIALLVYLVIAVSHLKMRKKMGKVEQQNLKVKMWLFPY
VTYVTIAAIIAVLVAMFAIDTLRSQAFLTMFVTVLIILSYFIFNRNKNITVLHPKSKNEESVRF

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258614005, Length=370, Percent_Identity=25.4054054054054, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI258614003, Length=370, Percent_Identity=25.4054054054054, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI258645169, Length=369, Percent_Identity=25.2032520325203, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI4507047, Length=430, Percent_Identity=23.953488372093, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI110347453, Length=330, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789017, Length=448, Percent_Identity=50, Blast_Score=428, Evalue=1e-121,
Organism=Escherichia coli, GI48994972, Length=463, Percent_Identity=37.3650107991361, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1786302, Length=415, Percent_Identity=38.7951807228916, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI87081708, Length=454, Percent_Identity=35.6828193832599, Blast_Score=302, Evalue=4e-83,
Organism=Escherichia coli, GI1788480, Length=411, Percent_Identity=39.9026763990268, Blast_Score=300, Evalue=9e-83,
Organism=Escherichia coli, GI1786789, Length=445, Percent_Identity=34.8314606741573, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1790653, Length=432, Percent_Identity=36.1111111111111, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI1786602, Length=394, Percent_Identity=38.5786802030457, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI87081915, Length=473, Percent_Identity=35.5179704016913, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI2367353, Length=460, Percent_Identity=24.3478260869565, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081869, Length=322, Percent_Identity=24.223602484472, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=374, Percent_Identity=24.0641711229947, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533459, Length=341, Percent_Identity=24.3401759530792, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=466, Percent_Identity=32.4034334763949, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320772, Length=468, Percent_Identity=32.6923076923077, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6320717, Length=489, Percent_Identity=30.0613496932515, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6324553, Length=462, Percent_Identity=31.8181818181818, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=425, Percent_Identity=32.7058823529412, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=28.3898305084746, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321629, Length=405, Percent_Identity=30.6172839506173, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=480, Percent_Identity=29.7916666666667, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324924, Length=473, Percent_Identity=28.5412262156448, Blast_Score=186, Evalue=7e-48,
Organism=Saccharomyces cerevisiae, GI6324990, Length=408, Percent_Identity=32.3529411764706, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=420, Percent_Identity=30, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319542, Length=485, Percent_Identity=27.4226804123711, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6319543, Length=394, Percent_Identity=26.9035532994924, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=489, Percent_Identity=26.7893660531697, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=28.8607594936709, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=490, Percent_Identity=25.1020408163265, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=400, Percent_Identity=27.75, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=496, Percent_Identity=22.1774193548387, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24666159, Length=334, Percent_Identity=23.6526946107784, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221512776, Length=334, Percent_Identity=23.6526946107784, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24667468, Length=407, Percent_Identity=23.3415233415233, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24668806, Length=405, Percent_Identity=22.962962962963, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356285, Length=405, Percent_Identity=22.962962962963, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668802, Length=405, Percent_Identity=22.962962962963, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50390; Mature: 50390

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVIFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAVNPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPQIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLIGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDAPKSFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAVSHLKMRKKMGKVEQQNLKVKMWLFPYVTYVTIAAIIAVLVAMFAID
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
TLRSQAFLTMFVTVLIILSYFIFNRNKNITVLHPKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MDKNLKKDLKIRHITMISIGGVIGAGLFVGSGAVVHSAGPGSIVSYALAGLLVIFVMRML
CCCCCHHCCCEEEEEEEEHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHH
GEMAAVNPTSGSFATYAREAIGPWAGYTIGWLYWFFWVIVIAIEATAGAGIIQYWIPQIP
HHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LWLLSLILTILLTLTNVFSVKSFGEFEYWFSFIKVISIVLFLCLGLAVILGFVPGTEAPG
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
TSNLIGQGGFMPNGISSVLLGITVVIFSFMGSEIVAVAAGESAEPVKAVKTATNSVIWRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
LVFFIGSIAVVVTLLPWNSANILKSPFVAVLEHIGIPAAAQIMNFIVLTAVLSCLNSGLY
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TNSRMLFSMAERGDAPKSFLKLNSSGVPVRAVLFGTFFAYIGVVFSYISPDKVFLFLVNA
CCCHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEC
SGGIALLVYLVIAVSHLKMRKKMGKVEQQNLKVKMWLFPYVTYVTIAAIIAVLVAMFAID
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
TLRSQAFLTMFVTVLIILSYFIFNRNKNITVLHPKSKNEESVRF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]