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The map label for this gene is fabH [H]

Identifier: 218232455

GI number: 218232455

Start: 1193861

End: 1194793

Strand: Direct

Name: fabH [H]

Synonym: BCB4264_A1228

Alternate gene names: 218232455

Gene position: 1193861-1194793 (Clockwise)

Preceding gene: 218232952

Following gene: 218234598

Centisome position: 22.03

GC content: 40.19

Gene sequence:

>933_bases
GTGAACGTGGGCATTTTAGGGATCGGAAGATATGTGCCAGAAAAAGTAGTCACAAATCACGATTTAGAGAAAATAATGGA
AACATCCGATGAATGGATTCGTACGAGAACGGGAATTGCAGAAAGACGCATTGCCGATGATACAATAGATACTTCATATA
TGGCCGTAGAGGCTTCTAAAAAAGCACTTGAAGATGCAGGAATTAGCGGAGAGGATATCGATCTTATTTTAGTAGCAACA
GTAACACCAGATCGTGCTTTTCCAGCAGTTGCTTGTGTAATTCAAGAAGCAATAGGAGCGAAACATGCAGCTGCAATGGA
TTTAAGTGCAGCATGTGCCGGTTTTATGTACGGAATGATTACAGCGCAGCAATTTATTCAAACAGGAACGTATAAAAATG
TATTAGTAGTTGGTAGTGATAAATTATCTAAAATTGTAGACTGGAACGATCGAAATACAGCAGTACTATTTGGAGACGGA
GCCGGTGCTATCGTAATGGGAGCTGTTTCAGAAGGTAAAGGTGTTCTATCTTTTGAATTAGGAGCAGACGGAAGTGGCGG
CAAGCACCTTTATCAAGACGAGTATGTTATGATGAATGGCAGAGAAGTGTTTAAATTTGCCGTTCGTCAACTTGGTGATT
CTTGTCTTCGCGTTTTAGATAAAGCTGGTCTTACGAAAGAAGATGTGGATTTCTTAGTACCGCATCAAGCAAACATTCGT
ATTATGGAATCTGCAAGAGAGAGGTTAAATTTACCACAAGAAAAAATGAGTATGACAATTGAGAAGTTCGGTAATACATC
AGCTTCTTCCATTCCGATTGCAATGGTAGAGGAATTGCAAAACGGACGTATTCAAGACGGTGATTTAATTATACTTGTTG
GTTTTGGCGGCGGATTAACATGGGGAGCAGTCGCTCTTCGTTGGGGTAAATAA

Upstream 100 bases:

>100_bases
GCTTTCTGTTTTATGCGAAATATATTCTAGACAAAAATACATTTATGTTTTAAAATTAGTACCAAGTCATAATAATTGAT
ATAAAACGGAGGGCTGCGAT

Downstream 100 bases:

>100_bases
GGACTGAGAGAAAAAAAGGAGTGTATTTTGTATGGAAAAAAAGAGGGTCGTAATTACAGGACTAGGAGCTGTTACACCGG
TCGGAACAGATGTTGAAACA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III protein 1; Beta-ketoacyl-ACP synthase III 1; KAS III 1 [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMETSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK

Sequences:

>Translated_310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMETSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK
>Mature_310_residues
MNVGILGIGRYVPEKVVTNHDLEKIMETSDEWIRTRTGIAERRIADDTIDTSYMAVEASKKALEDAGISGEDIDLILVAT
VTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMITAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDG
AGAIVMGAVSEGKGVLSFELGADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLTWGAVALRWGK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=318, Percent_Identity=44.9685534591195, Blast_Score=274, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 33468; Mature: 33468

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVGILGIGRYVPEKVVTNHDLEKIMETSDEWIRTRTGIAERRIADDTIDTSYMAVEASK
CCEEEEECCCCCCHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCCEEEEHHHH
KALEDAGISGEDIDLILVATVTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMI
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDGAGAIVMGAVSEGKGVLSFEL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEE
GADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
CCCCCCCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEECCCCCCEE
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLT
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCC
WGAVALRWGK
CHHEEEECCC
>Mature Secondary Structure
MNVGILGIGRYVPEKVVTNHDLEKIMETSDEWIRTRTGIAERRIADDTIDTSYMAVEASK
CCEEEEECCCCCCHHHHCCCHHHHHHHCHHHHHHHHCCHHHHHHCCCCCCCCEEEEHHHH
KALEDAGISGEDIDLILVATVTPDRAFPAVACVIQEAIGAKHAAAMDLSAACAGFMYGMI
HHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
TAQQFIQTGTYKNVLVVGSDKLSKIVDWNDRNTAVLFGDGAGAIVMGAVSEGKGVLSFEL
HHHHHHHCCCCCEEEEECCHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCEEEEEEE
GADGSGGKHLYQDEYVMMNGREVFKFAVRQLGDSCLRVLDKAGLTKEDVDFLVPHQANIR
CCCCCCCCCEECCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEECCCCCCEE
IMESARERLNLPQEKMSMTIEKFGNTSASSIPIAMVEELQNGRIQDGDLIILVGFGGGLT
HHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCC
WGAVALRWGK
CHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]