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The map label for this gene is rnc [H]

Identifier: 218232410

GI number: 218232410

Start: 3869896

End: 3870633

Strand: Reverse

Name: rnc [H]

Synonym: BCB4264_A3948

Alternate gene names: 218232410

Gene position: 3870633-3869896 (Counterclockwise)

Preceding gene: 218236154

Following gene: 218233136

Centisome position: 71.43

GC content: 36.72

Gene sequence:

>738_bases
ATGCCGTACCGAAAATATAGAGAAAAAAAATACGAAACAAAATATCGTGAAGCATTTAAAGTGTTTCAAGAAAAGATAGG
TATTACGTTTACAGATGAAAAATTATTGATTCAAGCATTTACGCATTCATCGTATGTGAATGAGCATCGAAAAAAACCGC
ATGAAGATAATGAGCGTCTTGAATTTCTTGGAGATGCAGTATTGGAACTGACTGTATCGCAGTATCTGTTTCAAAAATAT
CCGACAATGAGCGAAGGAGAGTTAACAAAACTACGTGCAGCTATTGTATGTGAGCCATCTCTTGTTCGTTTTGCGAACGA
ATTGTCATTTGGTAGCCTTGTTTTATTAGGAAAAGGTGAAGAAATGACAGGTGGACGTGAACGACCAGCTTTATTAGCGG
ATGTCTTTGAAGCGTTTATTGGTGCCCTTTATCTTGATCAAGGGCTAGAAACAGTTTGGGAATTCTTAAAAGAAATTGTA
TATCCGAAAATTAATGAGGGTGCTTTTTCTCATGTGATGGATTATAAGAGTCAGTTGCAAGAATTGATTCAGCGTGATGG
CAGTGGCAATGTTGAGTATCAAATTTTGCAAGAAAAAGGACCAGCTCACAATCGAGAATTTGTGTCACGTGTTACGTTAA
ATAACGTAGCTTTAGGTCTTGGTAGTGGTAAGTCGAAAAAAGAAGCAGAGCAACAAGCTGCTGCAGAAGCATTGAAAAAA
TTAAAAGAACAACTATAA

Upstream 100 bases:

>100_bases
ACTGTTGGCGATGCTGTGACTTACATAGAGAGTCATCTATAATGCTTAAGTGAAGTCCCGTTTTTTAGCGGGGCTTTCTG
GCTTATATCTGGAGGGACCT

Downstream 100 bases:

>100_bases
GGAATCCCCCTTTGAATGAGGGGGATTCCTTGTGCATAGAATGAAACTTTCTTTTTGTTTATAATGAAAAAGAAGGTAAA
TCCGTATAATACTTGTTTTT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKY
PTMSEGELTKLRAAIVCEPSLVRFANELSFGSLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWEFLKEIV
YPKINEGAFSHVMDYKSQLQELIQRDGSGNVEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
LKEQL

Sequences:

>Translated_245_residues
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKY
PTMSEGELTKLRAAIVCEPSLVRFANELSFGSLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWEFLKEIV
YPKINEGAFSHVMDYKSQLQELIQRDGSGNVEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
LKEQL
>Mature_244_residues
PYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERLEFLGDAVLELTVSQYLFQKYP
TMSEGELTKLRAAIVCEPSLVRFANELSFGSLVLLGKGEEMTGGRERPALLADVFEAFIGALYLDQGLETVWEFLKEIVY
PKINEGAFSHVMDYKSQLQELIQRDGSGNVEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKKL
KEQL

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=225, Percent_Identity=34.6666666666667, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI155030234, Length=225, Percent_Identity=34.6666666666667, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI1788920, Length=223, Percent_Identity=35.4260089686099, Blast_Score=126, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193202651, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17506883, Length=244, Percent_Identity=32.7868852459016, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17552834, Length=266, Percent_Identity=28.1954887218045, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6323895, Length=220, Percent_Identity=28.1818181818182, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17137682, Length=229, Percent_Identity=30.5676855895196, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28037; Mature: 27906

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERL
CCCHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EFLGDAVLELTVSQYLFQKYPTMSEGELTKLRAAIVCEPSLVRFANELSFGSLVLLGKGE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCC
EMTGGRERPALLADVFEAFIGALYLDQGLETVWEFLKEIVYPKINEGAFSHVMDYKSQLQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELIQRDGSGNVEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
HHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
LKEQL
HHHCC
>Mature Secondary Structure 
PYRKYREKKYETKYREAFKVFQEKIGITFTDEKLLIQAFTHSSYVNEHRKKPHEDNERL
CCHHHHHHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EFLGDAVLELTVSQYLFQKYPTMSEGELTKLRAAIVCEPSLVRFANELSFGSLVLLGKGE
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEECCC
EMTGGRERPALLADVFEAFIGALYLDQGLETVWEFLKEIVYPKINEGAFSHVMDYKSQLQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ELIQRDGSGNVEYQILQEKGPAHNREFVSRVTLNNVALGLGSGKSKKEAEQQAAAEALKK
HHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHH
LKEQL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA