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The map label for this gene is argH1 [H]

Identifier: 218232198

GI number: 218232198

Start: 3571541

End: 3573049

Strand: Reverse

Name: argH1 [H]

Synonym: BCB4264_A3657

Alternate gene names: 218232198

Gene position: 3573049-3571541 (Counterclockwise)

Preceding gene: 218234272

Following gene: 218235802

Centisome position: 65.94

GC content: 34.0

Gene sequence:

>1509_bases
ATGAAACAAAGTAAAGAAGAGTTTATAAAGAGTGAAGGCGCTGATTTCCCTGGGAAAACATATGTGGATTGTGTATTACA
ACATGTATTTCATTTTCAAAGAAATTACTTATTGAAAGATATGTTTCAAGTGCATAAAGCACATATTACGATGCTGACGG
AAGAAAATTTAATGAAAAAGGAAGAAGCTAAAGTTATATTACACGCATTAAAAAAGGTAGAGGGAATTCCAGAAGAGCAA
TTGCTCTATACAGAGCAGCATGAAGATCTCTTTTTTTTAGTCGAACATTTAATTTCTCAAGAAGCGAAATGCGATTTTGT
AAGTAATATGCATATTGGTAGAAGTAGAAATGATATGGGCGTAACGATGTATCGCATGAGTTTAAGGCGATATGTATTAC
GATTAATAGAACATCATTTGTTATTGCAAGAAAGTGTACTGCAACTTGCCGTTGATCATAAGGAAACGATCATGCCAGCT
TATACACATACACAACCAGCACAGCCAACAACATTTGGTCATTATACGTTAGCAATTTATGATACGATGCAAAGAGATTT
AGAACGAATGAAAAAAACGTACCAGCTTTTAAATCAGTCTCCAATGGGGGCAGCTGCACTCTCTACAACAAGTTTCCCGA
TTAAACGAGAACGAGTTGCTCATCTACTTGGATTTACAAATGTAATTGAGAACTCATATGATGCTGTTGCTGGAGCGGAT
TATTTATTAGAAGTTAGCTCGCTACTTATGGTAATGATGACGAATACGAGTAGATGGATTCATGACTTTTTGTTGTTAGC
AACGAAAGAATATGACGGTATTACTGTTGCAAAGCCATATGTACAAATCAGTAGTATTATGCCGCAAAAACGAAATCCGG
TTTCAATTGAACACGCTCGTGCAATTACGAGTAGTGCTTTAGGAGAAGCATTTACAGTATTTCAAATGATTCATAATACA
CCATTTGGTGATATTGTCGATACGGAAGATGACTTGCAGCCATATTTATATAAAGGGATTGAAAAGGCAATTCGTGTTTT
TTGTATGATGAATGCAGTGATCCGAACGATGAAAGTAGAAGAAGAAACGTTAAAAAGTCGTTCCTATAAACATGCAATAA
CGATAACGGATTTCGCCGATGTTTTAACAAAAAACTATGAAATTCCATTTCGGCATGCTCATCATGCAGCAAGTGCTATT
GCAAATATGTTATTGGAGCAGAAAAAAGAACTACATGAATTACACTTCAAAGAGGTAAATATGTACTTGCAAGAACATTT
TAAAATAAATTTATTAGAAAAAGAGTGGAAAGAAATTATAGCGCCAGAAGCTTTTATTCAAAAAAGAAATGTATACGGTG
GACCGAGTAAAAAAGAAATGAATCGTATGATTAAAAATCGACAAGAGTCATTTCGAAAAGAAGAAGATGTATTTGAAAAG
GAAAAACAGAGAATTTTACAAGCTGAAAATGCTTTGAATACATTAGCTTTGAATATTATTGAATCGTAA

Upstream 100 bases:

>100_bases
CTCGGTGCAGAGAGCACCGAGTTTATTTTTATGTACAAGCACTTTTTTTCTATCTCTGGGTATGATGGGTAGTAATACTT
AGGTGAGAGGGGAAAAGGTG

Downstream 100 bases:

>100_bases
AAGAGGGATTTAATGAATTAATCGCCAATACTTAATTAAAATATAAATAGAGAGAAGAGATTGTCGATGATTCAATTACA
TGTATATGAAGAGATTTTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 2; Arginosuccinase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFHFQRNYLLKDMFQVHKAHITMLTEENLMKKEEAKVILHALKKVEGIPEEQ
LLYTEQHEDLFFLVEHLISQEAKCDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLIEHHLLLQESVLQLAVDHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYQLLNQSPMGAAALSTTSFPIKRERVAHLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCMMNAVIRTMKVEEETLKSRSYKHAITITDFADVLTKNYEIPFRHAHHAASAI
ANMLLEQKKELHELHFKEVNMYLQEHFKINLLEKEWKEIIAPEAFIQKRNVYGGPSKKEMNRMIKNRQESFRKEEDVFEK
EKQRILQAENALNTLALNIIES

Sequences:

>Translated_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFHFQRNYLLKDMFQVHKAHITMLTEENLMKKEEAKVILHALKKVEGIPEEQ
LLYTEQHEDLFFLVEHLISQEAKCDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLIEHHLLLQESVLQLAVDHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYQLLNQSPMGAAALSTTSFPIKRERVAHLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCMMNAVIRTMKVEEETLKSRSYKHAITITDFADVLTKNYEIPFRHAHHAASAI
ANMLLEQKKELHELHFKEVNMYLQEHFKINLLEKEWKEIIAPEAFIQKRNVYGGPSKKEMNRMIKNRQESFRKEEDVFEK
EKQRILQAENALNTLALNIIES
>Mature_502_residues
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFHFQRNYLLKDMFQVHKAHITMLTEENLMKKEEAKVILHALKKVEGIPEEQ
LLYTEQHEDLFFLVEHLISQEAKCDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLIEHHLLLQESVLQLAVDHKETIMPA
YTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYQLLNQSPMGAAALSTTSFPIKRERVAHLLGFTNVIENSYDAVAGAD
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNT
PFGDIVDTEDDLQPYLYKGIEKAIRVFCMMNAVIRTMKVEEETLKSRSYKHAITITDFADVLTKNYEIPFRHAHHAASAI
ANMLLEQKKELHELHFKEVNMYLQEHFKINLLEKEWKEIIAPEAFIQKRNVYGGPSKKEMNRMIKNRQESFRKEEDVFEK
EKQRILQAENALNTLALNIIES

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=378, Percent_Identity=27.5132275132275, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI68303542, Length=378, Percent_Identity=27.5132275132275, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI68303547, Length=378, Percent_Identity=27.7777777777778, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI68303549, Length=378, Percent_Identity=25.6613756613757, Blast_Score=115, Evalue=9e-26,
Organism=Escherichia coli, GI1790398, Length=417, Percent_Identity=28.0575539568345, Blast_Score=176, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6321806, Length=425, Percent_Identity=27.2941176470588, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI221473854, Length=361, Percent_Identity=28.808864265928, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI78706858, Length=361, Percent_Identity=28.808864265928, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 58392; Mature: 58392

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFHFQRNYLLKDMFQVHKAHITMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHH
EEAKVILHALKKVEGIPEEQLLYTEQHEDLFFLVEHLISQEAKCDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCH
VTMYRMSLRRYVLRLIEHHLLLQESVLQLAVDHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYQLLNQSPMGAAALSTTSFPIKRERVAHLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCMMNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EETLKSRSYKHAITITDFADVLTKNYEIPFRHAHHAASAIANMLLEQKKELHELHFKEVN
HHHHHCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYLQEHFKINLLEKEWKEIIAPEAFIQKRNVYGGPSKKEMNRMIKNRQESFRKEEDVFEK
HHHHHHHHEEHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENALNTLALNIIES
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQSKEEFIKSEGADFPGKTYVDCVLQHVFHFQRNYLLKDMFQVHKAHITMLTEENLMKK
CCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHH
EEAKVILHALKKVEGIPEEQLLYTEQHEDLFFLVEHLISQEAKCDFVSNMHIGRSRNDMG
HHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCH
VTMYRMSLRRYVLRLIEHHLLLQESVLQLAVDHKETIMPAYTHTQPAQPTTFGHYTLAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCHHHHH
DTMQRDLERMKKTYQLLNQSPMGAAALSTTSFPIKRERVAHLLGFTNVIENSYDAVAGAD
HHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
YLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGITVAKPYVQISSIMPQKRNPVSIEHAR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCHHHHH
AITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCMMNAVIRTMKVE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EETLKSRSYKHAITITDFADVLTKNYEIPFRHAHHAASAIANMLLEQKKELHELHFKEVN
HHHHHCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MYLQEHFKINLLEKEWKEIIAPEAFIQKRNVYGGPSKKEMNRMIKNRQESFRKEEDVFEK
HHHHHHHHEEHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EKQRILQAENALNTLALNIIES
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]