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The map label for this gene is mntH [H]

Identifier: 218231942

GI number: 218231942

Start: 1779352

End: 1780647

Strand: Reverse

Name: mntH [H]

Synonym: BCB4264_A1874

Alternate gene names: 218231942

Gene position: 1780647-1779352 (Counterclockwise)

Preceding gene: 218234204

Following gene: 218234066

Centisome position: 32.86

GC content: 36.96

Gene sequence:

>1296_bases
ATGAATAAAGATATAACAAAAGATGAACATCTCCCTTCTGAAAGTACAACCGTACAATCAGCTCACTTAGCTTTAAGTGG
AGAAACAAAAGGCTGGAAAAGACTGTTACCATTTTTAGGACCCGCTTTTATCGCGTCCGTTGCTTATATTGATCCTGGCA
ACTTTGCTACAAATATCGCAGCTGGTTCACAATATGGATATTTACTATTATGGGTTATACTCGCTTCTAACTTAATGGCT
GTATTAATCCAAACTTTATCGGCTAAATTAGGAATTGCTACAGGAAACAATTTACCCGAAATAGCTCGTGAAAACTTTCC
AAAGCCTGTGTCTATCGGCTTATGGATACAAGGTGAACTAGTTATTATGGCTACAGATTTAGCGGAATTTATTGGAGCTG
CATTGGGGCTTTACTTACTATTTGGAATCCCCATGCTACCTGCCGCTTTAATTACAGCAGCCGGATCATTTATTATCCTT
GAATTTCAACGTAGAGGATTTCGTCCACTAGAAGCTATTATTACAGGAATGATTTTCATTGTAGTAATTGCTTTTGGGAT
TCAAGTTTTTTATGCAAAACCAGAATTAAGTCCCCTTCTTTCAGGACTATTTATTCCAAAATTCCAAGGTGTAGACAGTA
TATTACTTGCAGCAGGGATTTTAGGTGCGACAGTTATGCCGCATGCAATATACTTGCATTCTGCATTAACACAACGCCGT
GTGGTCGGAACAACTGACGAACAAAAGAAAAAGATTTTTCGTTTCGAATTTATCGATATTATTATTGCAATGGTTATTGC
TGGAGCAATTAATGCAAGTATGTTAATTGTAGCAGCTGCACTATTTTTTAAAAATGGCTTGCACGTTGAAGATTTAGATG
TTGCTTACACTCAATTTACCAATTTAGTAGGTCCTGTATCGGCTGCATTATTTGGGATTGGACTTTTATCAGCAGGACTA
TCTAGCTCTTCTGTCGGTACAATGTCGGGTGATATTATTATGCAAGGTTTCATTCGCATGCATATTCCGTTATATTTACG
CCGATTTATTACAATGATTCCACCACTAGTAATTATCGCTTTAGGTGTAAATCCAACATACGCTCTAGTCATGAGCCAAG
TCGTCTTATCATTCGGTATTGCATTTGCATTAGTGCCACTTATTATGTTTACAAGTAATAAAAAGATTATGGGTGCACTC
GTTAACCACCGCATAACAACATTTATCGCATGGATAATTGCTGCTCTCGTTATCGTTTTAAATATCTTCTTACTGTATCA
AACATTTGTAGGGTAA

Upstream 100 bases:

>100_bases
AAATGAAATTATCATATAACATATTTAAATGTATTGAAATAATGAGTAAGAATAAATACAATAATTTCATCAAGTTAACA
TTTTAAAGGGGAAAACTACT

Downstream 100 bases:

>100_bases
TGAAAAAGGGTATTCCAATTTTAATTTGGAATACCCTTTTTGGATGAAATGATTTTCTTCTAGTTACCACTTATGTATGC
CCCTCTTTCCGGCATCATCA

Product: manganese transport protein MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNKDITKDEHLPSESTTVQSAHLALSGETKGWKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGNNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGIQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTTDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAYTQFTNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSNKKIMGAL
VNHRITTFIAWIIAALVIVLNIFLLYQTFVG

Sequences:

>Translated_431_residues
MNKDITKDEHLPSESTTVQSAHLALSGETKGWKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGNNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGIQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTTDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAYTQFTNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSNKKIMGAL
VNHRITTFIAWIIAALVIVLNIFLLYQTFVG
>Mature_431_residues
MNKDITKDEHLPSESTTVQSAHLALSGETKGWKRLLPFLGPAFIASVAYIDPGNFATNIAAGSQYGYLLLWVILASNLMA
VLIQTLSAKLGIATGNNLPEIARENFPKPVSIGLWIQGELVIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIIL
EFQRRGFRPLEAIITGMIFIVVIAFGIQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
VVGTTDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAYTQFTNLVGPVSAALFGIGLLSAGL
SSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIALGVNPTYALVMSQVVLSFGIAFALVPLIMFTSNKKIMGAL
VNHRITTFIAWIIAALVIVLNIFLLYQTFVG

Specific function: H(+)-stimulated, highly selective, manganese uptake system. Can probably also transport cadmium, cobalt, copper and zinc, but not iron. May be the predominant transporter of manganese during logarithmic phase growth [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=437, Percent_Identity=31.5789473684211, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI295293167, Length=435, Percent_Identity=32.4137931034483, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI295293175, Length=435, Percent_Identity=32.4137931034483, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293173, Length=435, Percent_Identity=32.4137931034483, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI10835169, Length=435, Percent_Identity=32.4137931034483, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293171, Length=435, Percent_Identity=32.183908045977, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293169, Length=435, Percent_Identity=32.183908045977, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI295293178, Length=435, Percent_Identity=32.183908045977, Blast_Score=185, Evalue=9e-47,
Organism=Escherichia coli, GI1788736, Length=400, Percent_Identity=50.75, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI193210616, Length=468, Percent_Identity=29.7008547008547, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17569473, Length=395, Percent_Identity=33.1645569620253, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71999499, Length=440, Percent_Identity=30.2272727272727, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71993856, Length=245, Percent_Identity=32.6530612244898, Blast_Score=155, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6321841, Length=454, Percent_Identity=32.8193832599119, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323062, Length=396, Percent_Identity=33.0808080808081, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324450, Length=418, Percent_Identity=32.0574162679426, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24648607, Length=443, Percent_Identity=29.5711060948081, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362176, Length=443, Percent_Identity=29.5711060948081, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24648609, Length=443, Percent_Identity=29.5711060948081, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45553443, Length=420, Percent_Identity=30.4761904761905, Blast_Score=198, Evalue=7e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46514; Mature: 46514

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKDITKDEHLPSESTTVQSAHLALSGETKGWKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGNNLPEIARENFPKPVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIILEFQRRGFRPLEAIITGMIFI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHH
VVIAFGIQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGTTDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAYTQFT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSNKKIMGALVNHRITTFIAWIIAALVIVL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC
>Mature Secondary Structure
MNKDITKDEHLPSESTTVQSAHLALSGETKGWKRLLPFLGPAFIASVAYIDPGNFATNIA
CCCCCCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHCHHHHHHHHEECCCCCHHHCC
AGSQYGYLLLWVILASNLMAVLIQTLSAKLGIATGNNLPEIARENFPKPVSIGLWIQGEL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCEEEEEEECCE
VIMATDLAEFIGAALGLYLLFGIPMLPAALITAAGSFIILEFQRRGFRPLEAIITGMIFI
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCCCHHHHHHHHHHHH
VVIAFGIQVFYAKPELSPLLSGLFIPKFQGVDSILLAAGILGATVMPHAIYLHSALTQRR
HHHHHHHHHEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVGTTDEQKKKIFRFEFIDIIIAMVIAGAINASMLIVAAALFFKNGLHVEDLDVAYTQFT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHH
NLVGPVSAALFGIGLLSAGLSSSSVGTMSGDIIMQGFIRMHIPLYLRRFITMIPPLVIIA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEE
LGVNPTYALVMSQVVLSFGIAFALVPLIMFTSNKKIMGALVNHRITTFIAWIIAALVIVL
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NIFLLYQTFVG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10760146 [H]