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The map label for this gene is mepA [H]

Identifier: 218231927

GI number: 218231927

Start: 1603141

End: 1604496

Strand: Direct

Name: mepA [H]

Synonym: BCB4264_A1678

Alternate gene names: 218231927

Gene position: 1603141-1604496 (Clockwise)

Preceding gene: 218235264

Following gene: 218235669

Centisome position: 29.58

GC content: 35.55

Gene sequence:

>1356_bases
ATGGAAGCAACAGAAAAATTAAGAGAAAAACCGATAAAAAGCTTATTTATTTCTTATTTAATACCAGCCGTTCTTGGAAT
GGTATTAATGTCAGTGAATATTGTAATTGACGCGGTTATGATTAGTAGAGGAGTTGGGGCGAACGGTTTAGCAGGAGTGA
ACGTGGCTATTCCAGCATTTTCGATTTTCTTCTCTATTTCATTATGGATCGGAATGGGCGGGGCAACGTTATACTCCATT
GCATTAGGCGAAAATAAACGAGAAAGAGCAAGGTCTATTTTTACTCAATCCATGACGGTAGCAGTTGTTATCGTAGGGAT
TTTAGCAGCGATTTGCTTATGGAGAATAGAAGATTTAGCATACTTATTTGGTGCAAATGAAGTGATTCTACCATATGCGT
TAGACTATTTACACGTATTATTAACATTTGGAATGATATACGTTTTAGAAAATATTTTAAGTACATTCATACGAAATGAT
GGAAATCCTAATTTAGCAATGGCTGGTCTTGTTGTAACAGCTGTATTAAATATAGTGTTTGACTATATCTTTATTTTTAT
CTTTGGATGGGGCGTAACAGGTGCTGCTTCAGCGACTATTCTTTCGGCAGCGATTGGTTTCCTTGTATTATTAACTCATT
TCTTTAGAAAAAGTAGTATTTTAAAGTGGACGAAATTCCATTTTGAATGGGATACTGTCAAACAAATTATGGTGATTGGT
TTCCCAAGTTTTACAGCAGAAAGTACGGTTGCAATCGTAACGATTGGTTTTAATATCGCATTCGTCCAATATGCAGGAGA
AGTAGGAGTAGCTTCCTATGCGATGGTGAATAGTATTCATGCAATGACATTACTATTATTCTTTGGTGTTGGAGCAGCAT
TACAGCCAATTGCTAGTTTCCATTATGGGGCAAATTTATCAGAGAGACTTCGTGAAGGATTGAAGTTTGCTGTGAAAATT
GCAGTTGTCCTCGGAGGCATTGCGATAATTGTCGGATTATTCTTCGGGAAATATATCATTGGTTTATTTGATGTTCAATC
TCCAGAATTATTGGAGTTAACCTTAACAGGTATTAGCTTATTCTTTATCCAATACGTATTTTTAGGTTATAACATTGTGT
ATGGAGAGTATTTCCAATCAGTGCGACAAACGAAGAAATCAGTACTTATTATAATGAGCCGAGGATTACTATTTATTATT
CCATTGTTATGGATTATGCCGAAATTATTTGGTATAAATGGAATTTGGCTCGTTATGCCAGTTGCTGAAGTAATGACAGC
AATTATCGTATTTACTATGAATCGCATGAAACATCCTGTGCCATTAAATATGGCAGGAGAGAAAGAAGCGATATGA

Upstream 100 bases:

>100_bases
TATAAGTCAGTTACCTGTTTTTTAATTCTCTCTTGACCTTCAAGTTACTTGAAGGTTTAAACTAAGAAAAGAGAGTTGAA
AAAAAGGAGCATATTAGAGT

Downstream 100 bases:

>100_bases
TGAAGAAAATCCCCTTAAGCAATTAAGGGGATTTTTTATTCCTTTAAACTAATCGCAAAAGATCCATCTGTTTCTTGAAC
AGAAGCAAAGGCAACGTTTT

Product: putative MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKRERARSIFTQSMTVAVVIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTVKQIMVIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLKFAVKI
AVVLGGIAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVMTAIIVFTMNRMKHPVPLNMAGEKEAI

Sequences:

>Translated_451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKRERARSIFTQSMTVAVVIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTVKQIMVIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLKFAVKI
AVVLGGIAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVMTAIIVFTMNRMKHPVPLNMAGEKEAI
>Mature_451_residues
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAFSIFFSISLWIGMGGATLYSI
ALGENKRERARSIFTQSMTVAVVIVGILAAICLWRIEDLAYLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRND
GNPNLAMAGLVVTAVLNIVFDYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTVKQIMVIG
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASFHYGANLSERLREGLKFAVKI
AVVLGGIAIIVGLFFGKYIIGLFDVQSPELLELTLTGISLFFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFII
PLLWIMPKLFGINGIWLVMPVAEVMTAIIVFTMNRMKHPVPLNMAGEKEAI

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49560; Mature: 49560

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKRERARSIFTQSMTVAVVIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTVKQIMVIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHHHHHHHEE
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLKFAVKIAVVLGGIAIIVGLFFGKYIIGLFDVQSPELLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVMTAIIVFTMNRMKHPVPLNMAGEKEAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEATEKLREKPIKSLFISYLIPAVLGMVLMSVNIVIDAVMISRGVGANGLAGVNVAIPAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
SIFFSISLWIGMGGATLYSIALGENKRERARSIFTQSMTVAVVIVGILAAICLWRIEDLA
HHHHHHHHHHCCCCHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YLFGANEVILPYALDYLHVLLTFGMIYVLENILSTFIRNDGNPNLAMAGLVVTAVLNIVF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
DYIFIFIFGWGVTGAASATILSAAIGFLVLLTHFFRKSSILKWTKFHFEWDTVKQIMVIG
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEHHHHHHHHHEE
FPSFTAESTVAIVTIGFNIAFVQYAGEVGVASYAMVNSIHAMTLLLFFGVGAALQPIASF
CCCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
HYGANLSERLREGLKFAVKIAVVLGGIAIIVGLFFGKYIIGLFDVQSPELLELTLTGISL
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHH
FFIQYVFLGYNIVYGEYFQSVRQTKKSVLIIMSRGLLFIIPLLWIMPKLFGINGIWLVMP
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VAEVMTAIIVFTMNRMKHPVPLNMAGEKEAI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA