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The map label for this gene is pbuX [H]

Identifier: 218231926

GI number: 218231926

Start: 1546130

End: 1547452

Strand: Direct

Name: pbuX [H]

Synonym: BCB4264_A1627

Alternate gene names: 218231926

Gene position: 1546130-1547452 (Clockwise)

Preceding gene: 218231415

Following gene: 218231621

Centisome position: 28.53

GC content: 37.72

Gene sequence:

>1323_bases
ATGAAGCAGCATCCATTTAAAATTGCATCGCTTGGTATGCAACATATGCTTGCAATGTATGCTGGAGCAATTATCGTTCC
GCTTATTGTGGGCGGTGGACTTGGTTTAAATCAAAAAGAATTAACATATTTAGTCTCAATTGATTTATTAATGTGCGGCG
TTGCAACAATTTTACAAGCATTATCAAATCGCTTTTTCGGTATTGGACTTCCCGTTGTACTCGGTTGTACATTTACAGCC
GTTGGACCGATGATTGCGATTGGAAAACAATACGGTGTGTCTTCTATTTATGGAGCAATTATTGCTGCTGGGTTATTCGT
TGTTATTTTTGCGAAATTATTTGGAAAGCTTGTAAAACTATTTCCACCTGTTGTAACAGGATCTGTTGTTACTGTAATTG
GAGTTACACTTGTTCCAGCAGCAATTAATGATATGGCTGGCGGAGTAGGAAGTAAGGATTTCGGTAGTCTTGAAAATTTA
GCATTAGCATTTGGTGTGTTACTATTTATCATCATTATGTATCGTTTCTTTGATGGATTTATTCGTTCAATCTCTATTTT
ACTAGGTCTATTGTTCGGTACAATCGTTGCAGCGTTTATGGGGAAAGTAAGCTTGCAAGCGGTTGGAGAGGCTGATTGGT
TCCATGGTATTCAACCATTTTACTTTGGTACACCAACATTTGAATTAACACCAGTTATTACGATGATTCTCGTTGCTTGT
GTAGGGATTGTGGAAGCAACGGGTGTATACTTTGCATTATCTGATATTTGCAATAAAAAAATCGGTGAAAAAGAATTAAC
AAAGGGCTATCGAGCAGAAGGATTAGCGATGGTGTTAGGTGGCATTTTCAACGCGTTCCCATATACAACTTACTCTCAAA
ACGTAGGACTTGTTCAATTAACTGGAGTAAGAAATCGCGTTATTATTTATACTTGCGGTGGTATGTTAATCGTTCTTGGA
TTCATTCCTAAAATCGCAGCTATTACAACAATCATTCCGAAATCAGTACTTGGCGGTGCTATGCTCGCAATGTTCGGTAT
GGTAATGGCATATGGTATTAAAATGTTAAGTAGCGTTGATTTTGGCAAACAAGAAAACTTATTAATTGTTGCATGTTCTG
TCGGAATTGGGCTTGGGGTTACAGTTGTTCCTACATTATTCTCACAACTTCCTGAAAACATTCGTATTTTAACAGATAAC
GGAATTGTACTTGGAAGTGCGTCAGCAGTACTTTTAAATATCGTATTTAATATGGTGCCGCAGCGTAAAGTGAAAGTAAA
AGAAGAGCCGGTGTCTATGCAAAGTGCAGTAAGAGAAGCGTAA

Upstream 100 bases:

>100_bases
TGAACAAGGCGTTCGTGTTGAATCACTAGCAGAAATTGCATCACTTGATAACGGCACAGTTACATTTGTACAGCAAGAAA
CTGCGGAGGTGAAATAAACG

Downstream 100 bases:

>100_bases
AAAAGCAAGGTCTCGTTACGAGACCTTGCTTTTCTTTTTAAGTGGCATCATTTTCCCGTAAGTACCAAGACGCCAAATGT
ACTCAAGTGGTCCGTATTGG

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPVITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGKQENLLIVACSVGIGLGVTVVPTLFSQLPENIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKEEPVSMQSAVREA

Sequences:

>Translated_440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPVITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGKQENLLIVACSVGIGLGVTVVPTLFSQLPENIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKEEPVSMQSAVREA
>Mature_440_residues
MKQHPFKIASLGMQHMLAMYAGAIIVPLIVGGGLGLNQKELTYLVSIDLLMCGVATILQALSNRFFGIGLPVVLGCTFTA
VGPMIAIGKQYGVSSIYGAIIAAGLFVVIFAKLFGKLVKLFPPVVTGSVVTVIGVTLVPAAINDMAGGVGSKDFGSLENL
ALAFGVLLFIIIMYRFFDGFIRSISILLGLLFGTIVAAFMGKVSLQAVGEADWFHGIQPFYFGTPTFELTPVITMILVAC
VGIVEATGVYFALSDICNKKIGEKELTKGYRAEGLAMVLGGIFNAFPYTTYSQNVGLVQLTGVRNRVIIYTCGGMLIVLG
FIPKIAAITTIIPKSVLGGAMLAMFGMVMAYGIKMLSSVDFGKQENLLIVACSVGIGLGVTVVPTLFSQLPENIRILTDN
GIVLGSASAVLLNIVFNMVPQRKVKVKEEPVSMQSAVREA

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=224, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI40316845, Length=224, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI44680145, Length=428, Percent_Identity=23.8317757009346, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI44680143, Length=432, Percent_Identity=23.8425925925926, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082181, Length=438, Percent_Identity=41.5525114155251, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790087, Length=428, Percent_Identity=29.9065420560748, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI87082178, Length=434, Percent_Identity=32.0276497695853, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI87081818, Length=456, Percent_Identity=28.0701754385965, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788843, Length=432, Percent_Identity=27.0833333333333, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081750, Length=443, Percent_Identity=21.8961625282167, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17542262, Length=453, Percent_Identity=24.9448123620309, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17541904, Length=423, Percent_Identity=24.113475177305, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=190, Percent_Identity=26.8421052631579, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=436, Percent_Identity=22.2477064220184, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21356175, Length=418, Percent_Identity=26.0765550239234, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 46607; Mature: 46607

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure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CCCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]