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The map label for this gene is ycgO [H]

Identifier: 218231904

GI number: 218231904

Start: 1249802

End: 1251280

Strand: Reverse

Name: ycgO [H]

Synonym: BCB4264_A1289

Alternate gene names: 218231904

Gene position: 1251280-1249802 (Counterclockwise)

Preceding gene: 218231570

Following gene: 218233226

Centisome position: 23.09

GC content: 37.73

Gene sequence:

>1479_bases
ATGAGTACGCAGATGTTAACTTTAACTTCTATCTCAATTTACATGCTCGGGATGTTAGTCATTGGCTATTTCGCCTATAA
ACGAACGTCCAACTTAACAGATTATATGCTTGGCGGGCGTACACTAGGCCCCGCAGTAACAGCATTAAGTGCTGGAGCAT
CCGATATGAGTGGTTGGCTTTTAATGGGGTTACCCGGTGCAATGTTTAGCGTTGGATTAAGTAGTAGTTGGATTGCGATC
GGCCTAACACTAGGCGCATACGCAAACTGGCTTTATGTCGCTCCTCGCTTACGTACCTACTCAGAAATTGCAAATAACTC
TATTACTATCCCAGAATTTTTGGAACACCGTTTCCACGACAAGTCTCATATGCTACGTTTAGTATCTGGACTTGTTATTA
TGATTTTCTTTACTTTCTATGTAGCTTCAGGATTAGTTTCAGGCGCTGTATTATTTGAAAATTCATTTGGCATGAACTAT
CATGTTGGATTATTCATTGTAGCTGGCGTTGTTGTCGCTTACACATTATTTGGTGGTTTCTTAGCAGTAAGTTGGACAGA
CTTCGTGCAAGGAATCATTATGGTAGTTGCTCTTATTCTTGTTCCTACCGTTACAATTATGAATGTAAATGGACTTGGTC
CTGCATTTAGTACAATTAAATCGATTGATCCAACATTATTAGATATTTTTAAAGGTACTTCTGTATTAGGAATTATTTCA
TTATTCGCATGGGGCCTTGGTTATGTTGGACAACCTCATATTATCGTACGCTTTATGGCAATCTCTTCTGTAAAAGAGAT
TAAAAGTGCACGAAGAATTGGTATGAGCTGGATGATTTTCTCTGTTGTCGGAGCTATGTTTACCGGTCTTATCGGTATTG
CATACTACTCACAACAAGAGTTGACATTATCTAATCCAGAGACAATTTTCCTTGAACTTGGGAAAATTTTATTCCATCCA
CTTATTACTGGATTTTTATTAGCAGCCATTCTAGCAGCGATTATGAGTACAATTTCATCACAGCTACTCGTTACTTCTAG
TGCTGTAACTGAAGATTTATATCGTACATTCTTCAAACGTTCTGCATCTGATAAAGAACTTGTATTTGTCGGTCGTATGG
CTGTACTTGTTATTGCATTAGTTGGGTGCGCATTAGCGTTTAAACAAAATGATACGATTTTAGCTCTTGTTGGATACGCT
TGGGCTGGATTTGGTTCTTCATTCGGACCTGCTATTTTATTAAGCTTATATTGGAAACGTATGACGAAGTGGGGCGCACT
TGCCGGTATGATTTCTGGTGCCGCTACTGTTATTATATGGACTCAATTCAAATTCTTAAAAGATTTCTTATATGAAATGA
TTCCAGGTTTCGCTATTAGTTTACTAGCCATCGTAATTGTTAGTTTACTAACACAACCTTCAAAAGAAGTTGAAGAGCAA
TTTGAGGATTTCGAAAAACAACATCGTCATAATTTATAA

Upstream 100 bases:

>100_bases
CCTTGCCCAGCCAATTTTAAGGTGGGAGTTTTACTGCCCGTTTATGCGGGATAAATATGCATAACGCATCAAAAGACATG
ACAAAAGGAAGGGGAACTAC

Downstream 100 bases:

>100_bases
AAAAATCTCTGCTGTTATCATAACAGCAGAGATTTTTTACAGTTCGACAATCTTCTTATCAAATTTAACAAATTCTTTAT
GTTTCGTTAAATTTAACATA

Product: sodium/proline symporter family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFHDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVVALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSQQELTLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAVTEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKDFLYEMIPGFAISLLAIVIVSLLTQPSKEVEEQ
FEDFEKQHRHNL

Sequences:

>Translated_492_residues
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAI
GLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFHDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNY
HVGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVVALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSQQELTLSNPETIFLELGKILFHP
LITGFLLAAILAAIMSTISSQLLVTSSAVTEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYA
WAGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKDFLYEMIPGFAISLLAIVIVSLLTQPSKEVEEQ
FEDFEKQHRHNL
>Mature_491_residues
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWLLMGLPGAMFSVGLSSSWIAIG
LTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFHDKSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYH
VGLFIVAGVVVAYTLFGGFLAVSWTDFVQGIIMVVALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIISL
FAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSQQELTLSNPETIFLELGKILFHPL
ITGFLLAAILAAIMSTISSQLLVTSSAVTEDLYRTFFKRSASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYAW
AGFGSSFGPAILLSLYWKRMTKWGALAGMISGAATVIIWTQFKFLKDFLYEMIPGFAISLLAIVIVSLLTQPSKEVEEQF
EDFEKQHRHNL

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=491, Percent_Identity=54.1751527494908, Blast_Score=534, Evalue=1e-152,
Organism=Homo sapiens, GI110835708, Length=568, Percent_Identity=23.5915492957746, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI206597483, Length=441, Percent_Identity=25.1700680272109, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI206597487, Length=441, Percent_Identity=25.1700680272109, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI109659836, Length=447, Percent_Identity=23.7136465324385, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507031, Length=493, Percent_Identity=22.3123732251521, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI109659839, Length=460, Percent_Identity=22.6086956521739, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI11141885, Length=451, Percent_Identity=24.8337028824834, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI14140236, Length=547, Percent_Identity=21.5722120658135, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4507035, Length=364, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787251, Length=496, Percent_Identity=54.0322580645161, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1790503, Length=509, Percent_Identity=26.1296660117878, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87082237, Length=442, Percent_Identity=27.3755656108597, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790113, Length=493, Percent_Identity=23.1237322515213, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533094, Length=387, Percent_Identity=24.031007751938, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539284, Length=474, Percent_Identity=22.7848101265823, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645928, Length=383, Percent_Identity=26.6318537859008, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221459588, Length=398, Percent_Identity=24.8743718592965, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221459584, Length=373, Percent_Identity=21.71581769437, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24640370, Length=373, Percent_Identity=25.201072386059, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221459586, Length=385, Percent_Identity=25.1948051948052, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650192, Length=379, Percent_Identity=22.1635883905013, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651739, Length=349, Percent_Identity=24.9283667621776, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI281362918, Length=289, Percent_Identity=25.6055363321799, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221459582, Length=372, Percent_Identity=23.6559139784946, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24651741, Length=183, Percent_Identity=31.6939890710383, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573698, Length=410, Percent_Identity=22.9268292682927, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53748; Mature: 53617

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LMGLPGAMFSVGLSSSWIAIGLTLGAYANWLYVAPRLRTYSEIANNSITIPEFLEHRFHD
EECCCHHHHHHCCCCCHHHHHHHHHHHHHHHEECCHHHHHHHHHCCCCCHHHHHHHHHCC
KSHMLRLVSGLVIMIFFTFYVASGLVSGAVLFENSFGMNYHVGLFIVAGVVVAYTLFGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
LAVSWTDFVQGIIMVVALILVPTVTIMNVNGLGPAFSTIKSIDPTLLDIFKGTSVLGIIS
HHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHCCHHHHHHHCCCHHHHHHH
LFAWGLGYVGQPHIIVRFMAISSVKEIKSARRIGMSWMIFSVVGAMFTGLIGIAYYSQQE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LTLSNPETIFLELGKILFHPLITGFLLAAILAAIMSTISSQLLVTSSAVTEDLYRTFFKR
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SASDKELVFVGRMAVLVIALVGCALAFKQNDTILALVGYAWAGFGSSFGPAILLSLYWKR
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCHHHHHHHHHHHH
MTKWGALAGMISGAATVIIWTQFKFLKDFLYEMIPGFAISLLAIVIVSLLTQPSKEVEEQ
HHHHHHHHHHHCCCHHEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
FEDFEKQHRHNL
HHHHHHHHCCCC
>Mature Secondary Structure 
STQMLTLTSISIYMLGMLVIGYFAYKRTSNLTDYMLGGRTLGPAVTALSAGASDMSGWL
CCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHCCCCCCCCEE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HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]