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The map label for this gene is polC [H]

Identifier: 218231753

GI number: 218231753

Start: 3556989

End: 3557834

Strand: Reverse

Name: polC [H]

Synonym: BCB4264_A3646

Alternate gene names: 218231753

Gene position: 3557834-3556989 (Counterclockwise)

Preceding gene: 218232785

Following gene: 218235137

Centisome position: 65.65

GC content: 33.69

Gene sequence:

>846_bases
TTGAAAAACGCTACACATTTCATTGTGTTTGATATTGAAAGGAATTTCAGACCGTATAAATCAGAAGATCCATCAGAAAT
AGTTGATATCGGAGCTGTAAAAATAGAAATAGGTACAATGAAGATAATTGAAGAATTTTCGGAGTTAGTAAAACCAAGTG
CACGATTAACTCGTCATACAACAAAATTAACCGGTATTACGAAAAAAGATTTAATGGGTGTAGAAAAATTCCCTCAAATT
ATAGAGAAATTTATTCAGTTCATCGGCGAAGGTTCTATATTTGTTTCATGGGGAAAAGAAGATTATCGGTTTCTATCTCA
TGATTGTACATTATATGGTGTTGAATGCCCAAGTATAGAAAAAGAAAATAGAATTGATTTGCAAAAATTTGTTTTCCAAG
CATATGAGGAATTGTTTGAACATACACCAAGTTTACAATTTGCGGTAGAACAGCTCGCTTTAACGTGGGAAGGAAAACAG
CACCGTGCTTTAGCAGATGCTGAAAATACAGCAAATATACTTCTTAAAGTATATAGCGAGAGAGATATTAATAAGCGATA
CAAAAGACATGGTGAACTTGAACTTGTAAAAAACGGAAAACTAACAGAAAAAGCGAAAAAAAAGATGCGAAAATGGGTGT
TTAAAGAACTAAAGAAAAATACAGAACGCCCTTTTGAATGGAGTACATTTGAAAGTGGTGACACGTGGGAAAGTATAACG
GAAAGATATTATATAAGTGAAAATACAGTAGAACTCCTGAAAAAACATTTTCGTACAGCAGTGAGAAAAGCGGAACGGCA
GATTAGGTATTTGGCTGAGATGGAGGAGAATACAGAGGTTAAATGA

Upstream 100 bases:

>100_bases
CATTCATTTATTCGGAGTATTTTTGTATAAAGTACATGAATAAATAAATACTGAAAATAAAGTGTTTGTGTGAAAAGGAA
TTTAGAAAGAGGTAAATAAA

Downstream 100 bases:

>100_bases
ATTTCTCCTCCACCTCTAACTACATACATGTAATAACAGCGTATTGATATTAAATAGGCATCAATTTGTTGTTGTGATTG
TGCATTATAATTGTTTTGGG

Product: exonuclease

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKNATHFIVFDIERNFRPYKSEDPSEIVDIGAVKIEIGTMKIIEEFSELVKPSARLTRHTTKLTGITKKDLMGVEKFPQI
IEKFIQFIGEGSIFVSWGKEDYRFLSHDCTLYGVECPSIEKENRIDLQKFVFQAYEELFEHTPSLQFAVEQLALTWEGKQ
HRALADAENTANILLKVYSERDINKRYKRHGELELVKNGKLTEKAKKKMRKWVFKELKKNTERPFEWSTFESGDTWESIT
ERYYISENTVELLKKHFRTAVRKAERQIRYLAEMEENTEVK

Sequences:

>Translated_281_residues
MKNATHFIVFDIERNFRPYKSEDPSEIVDIGAVKIEIGTMKIIEEFSELVKPSARLTRHTTKLTGITKKDLMGVEKFPQI
IEKFIQFIGEGSIFVSWGKEDYRFLSHDCTLYGVECPSIEKENRIDLQKFVFQAYEELFEHTPSLQFAVEQLALTWEGKQ
HRALADAENTANILLKVYSERDINKRYKRHGELELVKNGKLTEKAKKKMRKWVFKELKKNTERPFEWSTFESGDTWESIT
ERYYISENTVELLKKHFRTAVRKAERQIRYLAEMEENTEVK
>Mature_281_residues
MKNATHFIVFDIERNFRPYKSEDPSEIVDIGAVKIEIGTMKIIEEFSELVKPSARLTRHTTKLTGITKKDLMGVEKFPQI
IEKFIQFIGEGSIFVSWGKEDYRFLSHDCTLYGVECPSIEKENRIDLQKFVFQAYEELFEHTPSLQFAVEQLALTWEGKQ
HRALADAENTANILLKVYSERDINKRYKRHGELELVKNGKLTEKAKKKMRKWVFKELKKNTERPFEWSTFESGDTWESIT
ERYYISENTVELLKKHFRTAVRKAERQIRYLAEMEENTEVK

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 33204; Mature: 33204

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNATHFIVFDIERNFRPYKSEDPSEIVDIGAVKIEIGTMKIIEEFSELVKPSARLTRHT
CCCCCEEEEEEEECCCCCCCCCCHHHHHHHCEEEEEHHHHHHHHHHHHHHCCHHHHHHHH
TKLTGITKKDLMGVEKFPQIIEKFIQFIGEGSIFVSWGKEDYRFLSHDCTLYGVECPSIE
HHHCCCCHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEEECCCCC
KENRIDLQKFVFQAYEELFEHTPSLQFAVEQLALTWEGKQHRALADAENTANILLKVYSE
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHCC
RDINKRYKRHGELELVKNGKLTEKAKKKMRKWVFKELKKNTERPFEWSTFESGDTWESIT
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
ERYYISENTVELLKKHFRTAVRKAERQIRYLAEMEENTEVK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNATHFIVFDIERNFRPYKSEDPSEIVDIGAVKIEIGTMKIIEEFSELVKPSARLTRHT
CCCCCEEEEEEEECCCCCCCCCCHHHHHHHCEEEEEHHHHHHHHHHHHHHCCHHHHHHHH
TKLTGITKKDLMGVEKFPQIIEKFIQFIGEGSIFVSWGKEDYRFLSHDCTLYGVECPSIE
HHHCCCCHHHHHCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEEEECCCCC
KENRIDLQKFVFQAYEELFEHTPSLQFAVEQLALTWEGKQHRALADAENTANILLKVYSE
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHCC
RDINKRYKRHGELELVKNGKLTEKAKKKMRKWVFKELKKNTERPFEWSTFESGDTWESIT
CCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
ERYYISENTVELLKKHFRTAVRKAERQIRYLAEMEENTEVK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]