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The map label for this gene is coaBC [H]

Identifier: 218231578

GI number: 218231578

Start: 3891091

End: 3892296

Strand: Reverse

Name: coaBC [H]

Synonym: BCB4264_A3968

Alternate gene names: 218231578

Gene position: 3892296-3891091 (Counterclockwise)

Preceding gene: 218236091

Following gene: 218233101

Centisome position: 71.83

GC content: 38.72

Gene sequence:

>1206_bases
ATGCTAAAAGGGAAAAAGATACTTCTATGTGTAACAGGAGGCATTGCGGTTTTTAAAGCAGCTGCGTTAACGAGTAAATT
GACACAATCTGGCGCGATTGTCAAAGTAATGATGAGTGAGTCGGCAATGAAGTTTGTTACGCCTCTTACATTCCAAGCGC
TTTCTCGCCATGATGTATATACGGATACATTCGATGAGAAAGACTCAGCTGTTATTGCTCATATTGATTTAGCAGATTGG
GCGGATGTTGTACTTGTCGCACCTGCTACTGCCAATTGTATTGGAAAGTTAGCTGGTGGTATTGCAGATGATATGATTAC
AACTACTTTGTTAGCTACTACAGCTCCGGTATGGATTGCGCCTGCTATGAATGTGCATATGTATGAAAATAAAATAGTTC
AAAAAAATATGATGACATTGAAAACGCTAGGATATACATTTATTGAGCCTGGGGAAGGCTTTTTAGCATGTGGATATGTA
GCGAAGGGACGACTAGAAGAACCTGAAGCAATTATTGCACGGTTAGAGGAAGCTTTCTCAGAACACAAACCATTGCAGGG
AAAAAGAATATTAATAACTGCTGGCCCAACACGTGAAAAGGTTGATCCAGTTCGTTTTATGACGAATTTTTCTTCTGGGA
AAATGGGGTATGCGATTGCGGAAGTGGCAGCGAATTTAGGCGCTGATGTTATACTCGTTTCAGGACCGACAGCATTAAAT
CCACCGTTACATGTAACGACAGTGCAAGTGGAATCTGCACAAGATATGTTAGAAGCAGTTCTTCAACATTATCAAAACGT
AGACGTTGTCATTAAAACAGCAGCAGTTGCAGATTATCGTCCGAAATATGTGCATGAGAATAAAATGAAAAAGCAAAATG
GTGATGCTGTCATTGAACTTGAAAGAACGGTGGATATTTTAAAAACGTTAGGTCAGAAAAAGGATAAACAGTTACTTATC
GGTTTTGCTGCTGAAACGACAAATGTAGAGGAATATGCAACGAAAAAACTACGTGAGAAAAATGCAGATATGATTGTCGC
GAATGATGTAAAAGCGCAAGGAGCTGGATTTGGCACGGATACGAATATTGTAACAATGTATAGAAAAGATGGAAAAGTTA
TTGAGTTGCCACTTTTAATGAAAAAAGAGGTAGCTCGTGAAATATTGAAGCAAATTGAAATGATGTTAGAAGATGATCGT
TTATGA

Upstream 100 bases:

>100_bases
AGGTTGTTATTTTTTTACGAAAGGAATGAAATATTGGTACTGACGAGCTGAGAATTCTATTTCAGTATTATAAGTTTGAA
AAAGAAAGAGGACGAGTCAT

Downstream 100 bases:

>100_bases
AATTTGCAAGTGTAATTGTTGATGTACCTGCCCGTCAGACAGATCGACCATTTGATTATATTATTCCTAAAAAATGGGAA
GATATTGTACAGACAGGAAT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQSGAIVKVMMSESAMKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLAGGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEHKPLQGKRILITAGPTREKVDPVRFMTNFSSGKMGYAIAEVAANLGADVILVSGPTALN
PPLHVTTVQVESAQDMLEAVLQHYQNVDVVIKTAAVADYRPKYVHENKMKKQNGDAVIELERTVDILKTLGQKKDKQLLI
GFAAETTNVEEYATKKLREKNADMIVANDVKAQGAGFGTDTNIVTMYRKDGKVIELPLLMKKEVAREILKQIEMMLEDDR
L

Sequences:

>Translated_401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQSGAIVKVMMSESAMKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLAGGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEHKPLQGKRILITAGPTREKVDPVRFMTNFSSGKMGYAIAEVAANLGADVILVSGPTALN
PPLHVTTVQVESAQDMLEAVLQHYQNVDVVIKTAAVADYRPKYVHENKMKKQNGDAVIELERTVDILKTLGQKKDKQLLI
GFAAETTNVEEYATKKLREKNADMIVANDVKAQGAGFGTDTNIVTMYRKDGKVIELPLLMKKEVAREILKQIEMMLEDDR
L
>Mature_401_residues
MLKGKKILLCVTGGIAVFKAAALTSKLTQSGAIVKVMMSESAMKFVTPLTFQALSRHDVYTDTFDEKDSAVIAHIDLADW
ADVVLVAPATANCIGKLAGGIADDMITTTLLATTAPVWIAPAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYV
AKGRLEEPEAIIARLEEAFSEHKPLQGKRILITAGPTREKVDPVRFMTNFSSGKMGYAIAEVAANLGADVILVSGPTALN
PPLHVTTVQVESAQDMLEAVLQHYQNVDVVIKTAAVADYRPKYVHENKMKKQNGDAVIELERTVDILKTLGQKKDKQLLI
GFAAETTNVEEYATKKLREKNADMIVANDVKAQGAGFGTDTNIVTMYRKDGKVIELPLLMKKEVAREILKQIEMMLEDDR
L

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=183, Percent_Identity=33.879781420765, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI87082301, Length=395, Percent_Identity=43.7974683544304, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17560194, Length=166, Percent_Identity=34.9397590361446, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=179, Percent_Identity=30.1675977653631, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=29.1891891891892, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43875; Mature: 43875

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGKKILLCVTGGIAVFKAAALTSKLTQSGAIVKVMMSESAMKFVTPLTFQALSRHDVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCHHHHHHHHCCCCC
TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLAGGIADDMITTTLLATTAPVWIA
CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS
CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH
EHKPLQGKRILITAGPTREKVDPVRFMTNFSSGKMGYAIAEVAANLGADVILVSGPTALN
HCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
PPLHVTTVQVESAQDMLEAVLQHYQNVDVVIKTAAVADYRPKYVHENKMKKQNGDAVIEL
CCEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCHHHHHHHHCCCCCEEEEE
ERTVDILKTLGQKKDKQLLIGFAAETTNVEEYATKKLREKNADMIVANDVKAQGAGFGTD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
TNIVTMYRKDGKVIELPLLMKKEVAREILKQIEMMLEDDRL
CCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLKGKKILLCVTGGIAVFKAAALTSKLTQSGAIVKVMMSESAMKFVTPLTFQALSRHDVY
CCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHCHHHHHHHHCCCCC
TDTFDEKDSAVIAHIDLADWADVVLVAPATANCIGKLAGGIADDMITTTLLATTAPVWIA
CCCCCCCCCEEEEEEECCCCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
PAMNVHMYENKIVQKNMMTLKTLGYTFIEPGEGFLACGYVAKGRLEEPEAIIARLEEAFS
CCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHHHH
EHKPLQGKRILITAGPTREKVDPVRFMTNFSSGKMGYAIAEVAANLGADVILVSGPTALN
HCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
PPLHVTTVQVESAQDMLEAVLQHYQNVDVVIKTAAVADYRPKYVHENKMKKQNGDAVIEL
CCEEEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCCHHHHHHHHCCCCCEEEEE
ERTVDILKTLGQKKDKQLLIGFAAETTNVEEYATKKLREKNADMIVANDVKAQGAGFGTD
HHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
TNIVTMYRKDGKVIELPLLMKKEVAREILKQIEMMLEDDRL
CCEEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]