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The map label for this gene is norM [H]

Identifier: 218231508

GI number: 218231508

Start: 1379467

End: 1380825

Strand: Reverse

Name: norM [H]

Synonym: BCB4264_A1435

Alternate gene names: 218231508

Gene position: 1380825-1379467 (Counterclockwise)

Preceding gene: 218236089

Following gene: 218230819

Centisome position: 25.48

GC content: 36.35

Gene sequence:

>1359_bases
ATGAAAGAAACTACTTCATTCTCACAAAAGTTAAAGCAATTTGTATTACTATTTTTTCCGATTTTCGTAACGCAAATGTC
ATTATTTGCGATGAGTTTTTTTGATACAACGATGTCAGGACATGCAAGTCCAACTGATTTAGCAGGTGTTGCAATTGGAA
CAAGTATATGGATTCCAGTTAGTACGGGGTTAACAGGAATTTTAATGGCTACTACTCCCATTGTTGCACAGCTCGTTGGA
TCCAAGAAAAAAGAGGACGTTCCCCACGTTGTCATACAAGCAGTTTATTTAGCAATTTGTGCTAGCTTCGTTGTTATCCT
CATCGGTTTTTTCGTCGTTTCACCTATTTTAAATGGCATGCGCTTAGAAGAACCTGTGGAACGTATTGCAGCGCAATTTT
TAAGTATTATTGCAATAGGAATTATACCTTTATTCACTTACACTGTTTTACGTGGATTTATTGATGCATTAGGAAAAACT
CGAACAACGATGATTATTACATTATTATCATTACCAATTAACGTAATATTAAATTACCTATTAATTTTTGGTAACTTCGG
TTTCCCAAAGCTTGGTGGTGTCGGAGCAGCAATTGCTTCCACTGCAACATATTGGTGCATTTTAATTATTACAGTCATTA
TTATTCAGACGAAAGAGCCTTTTGCCTCTTTCAACATTTTCAAACAATTATACCGACCTTCTCTTTCGAGTTGGATAGCA
TTCTTAAAACTTGGCGTTCCTATCGGATTTGCTATCTTTTTTGAAACGAGTATTTTCGCTGCGGTAACGCTCATGATGAG
TAATTTTAGTACGACAACTATTGCAGCTCACCAAGCAGCTATGAACTTTGCTTCCTTGTTATATATGACTCCGCTAAGTT
TAGCAATGGCAATGACTATTGCGGTTGGATTCGAAGTTGGAGCAAAACGTTACGATAATGCAAAACAATACGGACTGATT
GGAATTGGATTAGCCCTTGCCTTTGCTTTATTATATTCGATTCTTCTCTACTTCTTTGATGATCAAATTGCTTCTATTTA
TACGATAGATGCAAAAGTTCATCATTTAGCAAAAGAATTTCTTATCTTTGCAATTTTATTTCAAATTTCAGATGCAATTG
CAACCCCTGTACAAGGAGCTTTGCGTGGTTATAAAGATGTAAATGTTGCTCTAATTATGACTTTAATTGCTTATTGGATA
ATAGGTCTACCACTAGGTTACATATTAGCGACGTATACAGAATGGGCCGCGAAAGGCTATTGGATCGGTCTTATTATCGG
TCTAGCATTTGGCGCTGCCTTCCTACTTATCCGTCTCTTTCAAGTACAACGAAAATATACAACACAAAACAGCCGCTAA

Upstream 100 bases:

>100_bases
TTTATTGGCTTCATATGTTATAGGCGCGTATTTCTTTTCTAATCTTTGATTAAATTGTATGATAGTAAGAGTTTGTTTTT
TTATACGGAAAGGGGATTTT

Downstream 100 bases:

>100_bases
TAATAAAGCGGCTGTTTTCTTTATGCATATTTTTTCTTGTAACGTATAATATAATGAAAAAGAAAGGTGGGTACATATGG
ACGACAAAGAAAAAAAGCAA

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKETTSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPTDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGFFVVSPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIQTKEPFASFNIFKQLYRPSLSSWIA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYDNAKQYGLI
GIGLALAFALLYSILLYFFDDQIASIYTIDAKVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWI
IGLPLGYILATYTEWAAKGYWIGLIIGLAFGAAFLLIRLFQVQRKYTTQNSR

Sequences:

>Translated_452_residues
MKETTSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPTDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGFFVVSPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIQTKEPFASFNIFKQLYRPSLSSWIA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYDNAKQYGLI
GIGLALAFALLYSILLYFFDDQIASIYTIDAKVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWI
IGLPLGYILATYTEWAAKGYWIGLIIGLAFGAAFLLIRLFQVQRKYTTQNSR
>Mature_452_residues
MKETTSFSQKLKQFVLLFFPIFVTQMSLFAMSFFDTTMSGHASPTDLAGVAIGTSIWIPVSTGLTGILMATTPIVAQLVG
SKKKEDVPHVVIQAVYLAICASFVVILIGFFVVSPILNGMRLEEPVERIAAQFLSIIAIGIIPLFTYTVLRGFIDALGKT
RTTMIITLLSLPINVILNYLLIFGNFGFPKLGGVGAAIASTATYWCILIITVIIIQTKEPFASFNIFKQLYRPSLSSWIA
FLKLGVPIGFAIFFETSIFAAVTLMMSNFSTTTIAAHQAAMNFASLLYMTPLSLAMAMTIAVGFEVGAKRYDNAKQYGLI
GIGLALAFALLYSILLYFFDDQIASIYTIDAKVHHLAKEFLIFAILFQISDAIATPVQGALRGYKDVNVALIMTLIAYWI
IGLPLGYILATYTEWAAKGYWIGLIIGLAFGAAFLLIRLFQVQRKYTTQNSR

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=452, Percent_Identity=23.0088495575221, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI153792564, Length=408, Percent_Identity=24.2647058823529, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI38261960, Length=438, Percent_Identity=23.2876712328767, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI48994890, Length=433, Percent_Identity=35.796766743649, Blast_Score=260, Evalue=2e-70,
Organism=Escherichia coli, GI226510954, Length=462, Percent_Identity=23.1601731601732, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=410, Percent_Identity=24.390243902439, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6321821, Length=394, Percent_Identity=23.3502538071066, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49576; Mature: 49576

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA